Martijn P G Broen1, Nadia E Narayen1, Mark L Kuijf1,2, Nadeeka N W Dissanayaka3,4,5, Albert F G Leentjens2,6. 1. Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands. 2. School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands. 3. Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia. 4. The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia. 5. School of Psychology, The University of Queensland, Brisbane, Australia. 6. Department of Psychiatry, Maastricht University Medical Center, Maastricht, the Netherlands.
Abstract
OBJECTIVE: Prevalence rates of anxiety disorders in Parkinson's disease (PD) vary widely, ranging from 6% up to 55%. The aim of this systematic review was to calculate the average point prevalence of anxiety disorders and clinically relevant anxiety symptoms in PD. METHODS: Using PubMed, we carried out a systematic literature search for studies reporting Diagnostic and Statistical Manual-defined anxiety disorders or clinically relevant anxiety symptoms assessed by an anxiety rating scale. RESULTS: A total of 49 articles were included and assessed for quality, and 45 articles fulfilled the quality criteria. The average point prevalence of anxiety disorders in PD was 31%, with nonepisodic anxiety being more prevalent than episodic anxiety. Generalized anxiety disorder was the most frequent in 14%, followed by social phobia (13.8%), anxiety not otherwise specified (13.3%), and specific phobia (13.0%). Panic disorder with or without phobia was present in 6.8% of PD patients. Of the patients, 31% fulfilled the criteria for current multiple anxiety disorders. Based on anxiety rating scale cutoff scores, clinically significant anxiety symptoms were present in a weighted average of 25.7%. CONCLUSION: This systematic review confirms that anxiety, although often unrecognized, is very common and highlights the need for efficient identification of anxiety in PD.
OBJECTIVE: Prevalence rates of anxiety disorders in Parkinson's disease (PD) vary widely, ranging from 6% up to 55%. The aim of this systematic review was to calculate the average point prevalence of anxiety disorders and clinically relevant anxiety symptoms in PD. METHODS: Using PubMed, we carried out a systematic literature search for studies reporting Diagnostic and Statistical Manual-defined anxiety disorders or clinically relevant anxiety symptoms assessed by an anxiety rating scale. RESULTS: A total of 49 articles were included and assessed for quality, and 45 articles fulfilled the quality criteria. The average point prevalence of anxiety disorders in PD was 31%, with nonepisodic anxiety being more prevalent than episodic anxiety. Generalized anxiety disorder was the most frequent in 14%, followed by social phobia (13.8%), anxiety not otherwise specified (13.3%), and specific phobia (13.0%). Panic disorder with or without phobia was present in 6.8% of PDpatients. Of the patients, 31% fulfilled the criteria for current multiple anxiety disorders. Based on anxiety rating scale cutoff scores, clinically significant anxiety symptoms were present in a weighted average of 25.7%. CONCLUSION: This systematic review confirms that anxiety, although often unrecognized, is very common and highlights the need for efficient identification of anxiety in PD.
Authors: Sonja Rutten; Peter M van der Ven; Daniel Weintraub; Gregory M Pontone; Albert F G Leentjens; Henk W Berendse; Ysbrand D van der Werf; Odile A van den Heuvel Journal: Parkinsonism Relat Disord Date: 2017-07-05 Impact factor: 4.891
Authors: Jacob Taylor; William S Anderson; Jason Brandt; Zoltan Mari; Gregory M Pontone Journal: Am J Geriatr Psychiatry Date: 2016-09-03 Impact factor: 4.105
Authors: Ruth B Schneider; Peggy Auinger; Christopher G Tarolli; Julia Iourinets; María Cristina Gil-Díaz; Irene H Richard Journal: Parkinsonism Relat Disord Date: 2020-10-13 Impact factor: 4.891
Authors: Sonja Rutten; Chris Vriend; Ysbrand D van der Werf; Henk W Berendse; Daniel Weintraub; Odile A van den Heuvel Journal: Parkinsonism Relat Disord Date: 2017-02-01 Impact factor: 4.891
Authors: Melissa Deanna Shepard; Kate Perepezko; Martijn P G Broen; Jared Thomas Hinkle; Ankur Butala; Kelly A Mills; Julie Nanavati; Nicole Mercado Fischer; Paul Nestadt; Gregory Pontone Journal: J Neurol Neurosurg Psychiatry Date: 2019-01-19 Impact factor: 10.154