AIM: To compare quality of life, level of disability, and caregiver burden in 3 groups of people with Parkinson disease (PD): those with mild cognitive impairment (PD-MCI), those with dementia (PDD), and those with no cognitive impairment (PD-NC). BACKGROUND: Although the cognitive profile of those with PD-MCI and PDD has been well described, little is known about the personal and clinical impact of cognitive impairment and its impact on caregivers. METHOD: Quality of life and disability were measured in 3 groups of participants with PD (PD-NC, n=54; PD-MCI, n=48; and PDD, n=25). The PD-MCI group was classified using Movement Disorder Society Task Force consensus criteria. Caregivers (n=102) in the 3 groups were assessed using the Zarit Burden Inventory. RESULTS: Both quality of life and caregiver burden were similar in the 2 groups without dementia but were significantly different in those with PDD. In contrast, global disability was progressively greater as cognition declined across the 3 PD groups: PD-NC<PD-MCI<PDD and on the Activities of Daily Living scale a step up in impairment was seen with the presence of any cognitive impairment. CONCLUSIONS: The presence of dementia significantly increases caregiver burden and decreases quality of life. However, even mild levels of cognitive impairment increase disability and overall functional impairment progresses in tandem with cognitive decline.
AIM: To compare quality of life, level of disability, and caregiver burden in 3 groups of people with Parkinson disease (PD): those with mild cognitive impairment (PD-MCI), those with dementia (PDD), and those with no cognitive impairment (PD-NC). BACKGROUND: Although the cognitive profile of those with PD-MCI and PDD has been well described, little is known about the personal and clinical impact of cognitive impairment and its impact on caregivers. METHOD: Quality of life and disability were measured in 3 groups of participants with PD (PD-NC, n=54; PD-MCI, n=48; and PDD, n=25). The PD-MCI group was classified using Movement Disorder Society Task Force consensus criteria. Caregivers (n=102) in the 3 groups were assessed using the Zarit Burden Inventory. RESULTS: Both quality of life and caregiver burden were similar in the 2 groups without dementia but were significantly different in those with PDD. In contrast, global disability was progressively greater as cognition declined across the 3 PD groups: PD-NC<PD-MCI<PDD and on the Activities of Daily Living scale a step up in impairment was seen with the presence of any cognitive impairment. CONCLUSIONS: The presence of dementia significantly increases caregiver burden and decreases quality of life. However, even mild levels of cognitive impairment increase disability and overall functional impairment progresses in tandem with cognitive decline.
Authors: Shelby Hughes; Daniel O Claassen; Wery P M van den Wildenberg; Fenna T Phibbs; Elise B Bradley; Scott A Wylie; Nelleke C van Wouwe Journal: J Int Neuropsychol Soc Date: 2018-12-03 Impact factor: 2.892
Authors: A Markser; Franziska Maier; C J Lewis; T A Dembek; D Pedrosa; C Eggers; L Timmermann; E Kalbe; G R Fink; Lothar Burghaus Journal: J Neurol Date: 2015-07-11 Impact factor: 4.849
Authors: Kelly A Mills; Zoltan Mari; Gregory M Pontone; Alexander Pantelyat; Angela Zhang; Nadine Yoritomo; Emma Powers; Jason Brandt; Ted M Dawson; Liana S Rosenthal Journal: Parkinsonism Relat Disord Date: 2016-09-27 Impact factor: 4.891
Authors: Francesca V Lopez; Beata Ferencz; Brittany Y Rohl; Erin Trifilio; Bonnie Scott; Michael S Okun; Michael Marsiske; Dawn Bowers Journal: Parkinsonism Relat Disord Date: 2018-09-01 Impact factor: 4.891
Authors: Tyler Bell; Ana Luisa Dávila; Olivio Clay; Kyriakos S Markides; Ross Andel; Michael Crowe Journal: Int Psychogeriatr Date: 2017-05-17 Impact factor: 3.878