Literature DB >> 3432953

The sensitivity to trypanocidal drugs of Trypanosoma vivax isolated in Kenya and Somalia.

A Schönefeld1, D Röttcher, S K Moloo.   

Abstract

The drug sensitivity of seven Trypanosoma vivax-isolates from Kenya and Somalia was examined. With the exception of diminazene aceturate all commercially available trypanocidal drugs failed to effect a cure. The results suggest the existence of multiple drug resistance of T. vivax-strains, geographically widely distributed along the East African Coast. The isolates were resistant to the recommended dose rates of isometamidium, homidium and quinapyramine. Isometamidium showed no prophylactic properties when tested against one of the isolates. All were sensitive to diminazene aceturate.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3432953

Source DB:  PubMed          Journal:  Trop Med Parasitol        ISSN： 0177-2392


  10 in total

1.  Differences in sensitivity of Kenyan Trypanosoma vivax populations to the prophylactic and therapeutic actions of isometamidium chloride in Boran cattle.

Authors:  A S Peregrine; S K Moloo; D D Whitelaw
Journal:  Trop Anim Health Prod       Date:  1991-02       Impact factor: 1.559

2.  In vitro assessment of isometamidium chloride susceptibility of Trypanosoma vivax bloodstream forms.

Authors:  E Zweygarth; R Kaminsky; M A Gray
Journal:  Parasitol Res       Date:  1991       Impact factor: 2.289

3.  Modulation of mitochondrial electrical potential: a candidate mechanism for drug resistance in African trypanosomes.

Authors:  J M Wilkes; W Mulugeta; C Wells; A S Peregrine
Journal:  Biochem J       Date:  1997-09-15       Impact factor: 3.857

4.  Trypanocidal drugs and their effect on parasitaemia, specific IgG production and protective immunity in rats infected with Trypanosoma lewisi.

Authors:  C M Ndarathi
Journal:  Parasitol Res       Date:  1992       Impact factor: 2.289

5.  Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense.

Authors:  C J Bacchi; H C Nathan; T Livingston; G Valladares; M Saric; P D Sayer; A R Njogu; A B Clarkson
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

6.  Cross-resistance associated with development of resistance to isometamidium in a clone of Trypanosoma congolense.

Authors:  A S Peregrine; M A Gray; S K Moloo
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

7.  Therapeutic activity of isometamidium chloride in Boran cattle against a tsetse-transmitted clone of Trypanosoma congolense with a low level of drug resistance.

Authors:  I A Sutherland; V Codjia; S K Moloo; P H Holmes; A S Peregrine
Journal:  Trop Anim Health Prod       Date:  1992-08       Impact factor: 1.559

8.  Trypanosomiasis control in Boran cattle in Kenya: a comparison between chemoprophylaxis and a parasite detection and intravenous treatment method using isometamidium chloride.

Authors:  S Münstermann; R J Mbura; S H Maloo; K F Löhr
Journal:  Trop Anim Health Prod       Date:  1992-02       Impact factor: 1.559

9.  Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense.

Authors:  D Zilberstein; J Wilkes; H Hirumi; A S Peregrine
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857

10.  The effect of isometamidium chloride on insect forms of drug-sensitive and drug-resistant stocks of Trypanosoma vivax: studies in vitro and in tsetse flies.

Authors:  R Kaminsky; F Chuma; E Zweygarth; D S Kitosi; S K Moloo
Journal:  Parasitol Res       Date:  1991       Impact factor: 2.289
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.