Literature DB >> 2118325

Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense.

C J Bacchi1, H C Nathan, T Livingston, G Valladares, M Saric, P D Sayer, A R Njogu, A B Clarkson.   

Abstract

DL-alpha-Difluoromethylornithine is an enzyme-activated inhibitor of ornithine decarboxylase and an antagonist of polyamine metabolism that has been successful in clinical trials against West African sleeping sickness caused by Trypanosoma brucei gambiense. Its potential for use against the more virulent East African form of the disease, caused by T. brucei rhodesiense, is not certain. We examined 14 East African clinical isolates from the Kenya Trypanosomiasis Research Institute strain bank plus 2 established isolates for susceptibility to DL-alpha-difluoromethylornithine and to standard trypanocides. Seven of 16 strains were partially or totally refractory to DL-alpha-difluoromethylornithine in our test system. Four strains were also refractory to arsenical drugs, and five were refractory to diamidines. The results indicate that other novel agents or combinations of established agents may be needed for chemotherapy of East African disease.

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Year:  1990        PMID： 2118325      PMCID： PMC171781          DOI： 10.1128/AAC.34.6.1183

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Quantitative effects of salycylhydroxamic acid and glycerol on Trypanosoma brucei glycolysis in vitro and in vivo.

Authors:  F H Brohn; A B Clarkson
Journal:  Acta Trop       Date:  1978-03       Impact factor: 3.112

2.  Necessity of antibody response in the treatment of African trypanosomiasis with alpha-difluoromethylornithine.

Authors:  A J Bitonti; P P McCann; A Sjoerdsma
Journal:  Biochem Pharmacol       Date:  1986-01-15       Impact factor: 5.858

3.  The relationship between duration of infection with Trypanosoma brucei in mice and the efficacy of chemotherapy.

Authors:  F W Jennings; D D Whitelaw; G M Urquhart
Journal:  Parasitology       Date:  1977-10       Impact factor: 3.234

4.  Drug sensitivity of pleomorphic Trypanosoma rhodesiense.

Authors:  J Williamson
Journal:  Trans R Soc Trop Med Hyg       Date:  1983       Impact factor: 2.184

5.  Role of antibody in the elimination of trypanosomes after DL-alpha-difluoromethylornithine chemotherapy.

Authors:  A L de Gee; P P McCann; J M Mansfield
Journal:  J Parasitol       Date:  1983-10       Impact factor: 1.276

6.  Isoenzyme characterization of some Trypanozoon stocks from a recent trypanosomiasis epidemic in Uganda.

Authors:  W C Gibson; J K Gashumba
Journal:  Trans R Soc Trop Med Hyg       Date:  1983       Impact factor: 2.184

7.  In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei.

Authors:  C J Bacchi; J Garofalo; D Mockenhaupt; P P McCann; K A Diekema; A E Pegg; H C Nathan; E A Mullaney; L Chunosoff; A Sjoerdsma; S H Hutner
Journal:  Mol Biochem Parasitol       Date:  1983-03       Impact factor: 1.759

8.  Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei.

Authors:  P Dukes
Journal:  Trans R Soc Trop Med Hyg       Date:  1984       Impact factor: 2.184

9.  Morphological changes in Trypanosoma brucei rhodesiense following inhibition of polyamine biosynthesis in vivo.

Authors:  A L de Gee; P H Carstens; P P McCann; J M Mansfield
Journal:  Tissue Cell       Date:  1984       Impact factor: 2.466

10.  Role of calcium in trypanocidal drug action.

Authors:  A B Clarkson; B O Amole
Journal:  Science       Date:  1982-06-18       Impact factor: 47.728
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  24 in total

Review 1.  Recent advances in the development of polyamine analogues as antitumor agents.

Authors:  Robert A Casero; Patrick M Woster
Journal:  J Med Chem       Date:  2009-08-13       Impact factor: 7.446

2.  Synthesis and antitrypanosomal activities of a series of 7-deaza-5'-noraristeromycin derivatives with variations in the cyclopentyl ring substituents.

Authors:  K L Seley; S W Schneller; D Rattendi; S Lane; C J Bacchi
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

3.  In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

Authors:  R Brun; Y Bühler; U Sandmeier; R Kaminsky; C J Bacchi; D Rattendi; S Lane; S L Croft; D Snowdon; V Yardley; G Caravatti; J Frei; J Stanek; H Mett
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

4.  In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

Authors:  C J Bacchi; R Brun; S L Croft; K Alicea; Y Bühler
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

5.  Alterations in ornithine decarboxylase characteristics account for tolerance of Trypanosoma brucei rhodesiense to D,L-alpha-difluoromethylornithine.

Authors:  M Iten; H Mett; A Evans; J C Enyaru; R Brun; R Kaminsky
Journal:  Antimicrob Agents Chemother       Date:  1997-09       Impact factor: 5.191

6.  In vitro and in vivo activities of trybizine hydrochloride against various pathogenic trypanosome species.

Authors:  R Kaminsky; R Brun
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

7.  A molecular mechanism for eflornithine resistance in African trypanosomes.

Authors:  Isabel M Vincent; Darren Creek; David G Watson; Mohammed A Kamleh; Debra J Woods; Pui Ee Wong; Richard J S Burchmore; Michael P Barrett
Journal:  PLoS Pathog       Date:  2010-11-24       Impact factor: 6.823

8.  5'-Alkyl-substituted analogs of 5'-methylthioadenosine as trypanocides.

Authors:  C J Bacchi; J R Sufrin; H C Nathan; A J Spiess; T Hannan; J Garofalo; K Alecia; L Katz; N Yarlett
Journal:  Antimicrob Agents Chemother       Date:  1991-07       Impact factor: 5.191

Review 9.  Human antiprotozoal therapy: past, present, and future.

Authors:  M Khaw; C B Panosian
Journal:  Clin Microbiol Rev       Date:  1995-07       Impact factor: 26.132

10.  Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor.

Authors:  Cyrus J Bacchi; Robert H Barker; Aixa Rodriguez; Bradford Hirth; Donna Rattendi; Nigel Yarlett; Clifford L Hendrick; Edmund Sybertz
Journal:  Antimicrob Agents Chemother       Date:  2009-05-18       Impact factor: 5.191
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