Literature DB >> 34320204

Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores.

Daniel R Barnes1, Valentina Silvestri2, Goska Leslie1, Lesley McGuffog1, Joe Dennis1, Xin Yang1, Julian Adlard3, Bjarni A Agnarsson4,5, Munaza Ahmed6, Kristiina Aittomäki7, Irene L Andrulis8,9, Adalgeir Arason4,10, Norbert Arnold11,12, Bernd Auber13, Jacopo Azzollini14, Judith Balmaña15,16, Rosa B Barkardottir4,10, Daniel Barrowdale1, Julian Barwell17, Muriel Belotti18, Javier Benitez19,20, Pascaline Berthet21, Susanne E Boonen22, Åke Borg23, Aniko Bozsik24, Angela F Brady25, Paul Brennan26, Carole Brewer27, Joan Brunet28, Agostino Bucalo2, Saundra S Buys29, Trinidad Caldés30, Maria A Caligo31, Ian Campbell32,33, Hayley Cassingham34, Lise Lotte Christensen35, Giulia Cini36, Kathleen B M Claes37, Jackie Cook38, Anna Coppa39,40, Laura Cortesi40, Giuseppe Damante41, Esther Darder28, Rosemarie Davidson42, Miguel de la Hoya30, Kim De Leeneer37, Robin de Putter37, Jesús Del Valle28, Orland Diez15,43, Yuan Chun Ding44, Susan M Domchek45, Alan Donaldson46, Jacqueline Eason47, Ros Eeles48, Christoph Engel49,50, D Gareth Evans51,52, Lidia Feliubadaló28, Florentia Fostira53, Megan Frone54, Debra Frost1, David Gallagher55, Andrea Gehrig56, Sophie Giraud57, Gord Glendon8, Andrew K Godwin58, David E Goldgar59, Mark H Greene54, Helen Gregory60, Eva Gross61, Eric Hahnen62,63, Ute Hamann64, Thomas V O Hansen65, Helen Hanson66, Julia Hentschel67, Judit Horvath68, Louise Izatt69, Angel Izquierdo28, Paul A James33,70, Ramunas Janavicius71,72, Uffe Birk Jensen73, Oskar Th Johannsson74, Esther M John75,76, Gero Kramer77, Lone Kroeldrup22, Torben A Kruse22, Charlotte Lautrup78,79, Conxi Lazaro28, Fabienne Lesueur80,81,82, Adria Lopez-Fernández15, Phuong L Mai83, Siranoush Manoukian14, Zoltan Matrai84, Laura Matricardi85, Kara N Maxwell86, Noura Mebirouk80,81,82, Alfons Meindl61, Marco Montagna85, Alvaro N Monteiro87, Patrick J Morrison88, Taru A Muranen89, Alex Murray90, Katherine L Nathanson45, Susan L Neuhausen44, Heli Nevanlinna89, Tu Nguyen-Dumont91,92, Dieter Niederacher93, Edith Olah24, Olufunmilayo I Olopade94, Domenico Palli95, Michael T Parsons96, Inge Sokilde Pedersen79,97,98, Bernard Peissel14, Pedro Perez-Segura30, Paolo Peterlongo99, Annabeth H Petersen100, Pedro Pinto101, Mary E Porteous102, Caroline Pottinger90, Miquel Angel Pujana103, Paolo Radice104, Juliane Ramser105, Johanna Rantala106, Mark Robson107, Mark T Rogers90, Karina Rønlund100, Andreas Rump108, Ana María Sánchez de Abajo109, Payal D Shah86, Saba Sharif110, Lucy E Side111, Christian F Singer112, Zsofia Stadler107, Linda Steele44, Dominique Stoppa-Lyonnet18,113,114, Christian Sutter115, Yen Yen Tan116, Manuel R Teixeira101,117, Alex Teulé28, Darcy L Thull118, Marc Tischkowitz119,120, Amanda E Toland121, Stefania Tommasi122, Angela Toss40, Alison H Trainer70,123, Vishakha Tripathi69, Virginia Valentini2, Christi J van Asperen124, Marta Venturelli40, Alessandra Viel36, Joseph Vijai107,125, Lisa Walker126, Shan Wang-Gohrke127, Barbara Wappenschmidt62,63, Anna Whaite128, Ines Zanna95, Kenneth Offit107,125, Mads Thomassen22, Fergus J Couch129, Rita K Schmutzler62,63,130, Jacques Simard131, Douglas F Easton1,132, Georgia Chenevix-Trench96, Antonis C Antoniou1, Laura Ottini2.   

Abstract

BACKGROUND: Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant carriers.
METHODS: 483 BRCA1 and 1318 BRCA2 European ancestry male carriers were available from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). A 147-single nucleotide polymorphism (SNP) prostate cancer PRS (PRSPC) and a 313-SNP breast cancer PRS were evaluated. There were 3 versions of the breast cancer PRS, optimized to predict overall (PRSBC), estrogen receptor (ER)-negative (PRSER-), or ER-positive (PRSER+) breast cancer risk.
RESULTS: PRSER+ yielded the strongest association with breast cancer risk. The odds ratios (ORs) per PRSER+ standard deviation estimates were 1.40 (95% confidence interval [CI] =1.07 to 1.83) for BRCA1 and 1.33 (95% CI = 1.16 to 1.52) for BRCA2 carriers. PRSPC was associated with prostate cancer risk for BRCA1 (OR = 1.73, 95% CI = 1.28 to 2.33) and BRCA2 (OR = 1.60, 95% CI = 1.34 to 1.91) carriers. The estimated breast cancer odds ratios were larger after adjusting for female relative breast cancer family history. By age 85 years, for BRCA2 carriers, the breast cancer risk varied from 7.7% to 18.4% and prostate cancer risk from 34.1% to 87.6% between the 5th and 95th percentiles of the PRS distributions.
CONCLUSIONS: Population-based prostate and female breast cancer PRS are associated with a wide range of absolute breast and prostate cancer risks for male BRCA1 and BRCA2 carriers. These findings warrant further investigation aimed at providing personalized cancer risks for male carriers and informing clinical management.
© The Author(s) 2021. Published by Oxford University Press.

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Year:  2022        PMID： 34320204      PMCID： PMC8755508          DOI： 10.1093/jnci/djab147

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   11.816


  42 in total

1.  RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.

Authors:  Antonis C Antoniou; Olga M Sinilnikova; Jacques Simard; Mélanie Léoné; Martine Dumont; Susan L Neuhausen; Jeffery P Struewing; Dominique Stoppa-Lyonnet; Laure Barjhoux; David J Hughes; Isabelle Coupier; Muriel Belotti; Christine Lasset; Valérie Bonadona; Yves-Jean Bignon; Timothy R Rebbeck; Theresa Wagner; Henry T Lynch; Susan M Domchek; Katherine L Nathanson; Judy E Garber; Jeffrey Weitzel; Steven A Narod; Gail Tomlinson; Olufunmilayo I Olopade; Andrew Godwin; Claudine Isaacs; Anna Jakubowska; Jan Lubinski; Jacek Gronwald; Bohdan Górski; Tomasz Byrski; Tomasz Huzarski; Susan Peock; Margaret Cook; Caroline Baynes; Alexandra Murray; Mark Rogers; Peter A Daly; Huw Dorkins; Rita K Schmutzler; Beatrix Versmold; Christoph Engel; Alfons Meindl; Norbert Arnold; Dieter Niederacher; Helmut Deissler; Amanda B Spurdle; Xiaoqing Chen; Nicola Waddell; Nicole Cloonan; Tomas Kirchhoff; Kenneth Offit; Eitan Friedman; Bella Kaufmann; Yael Laitman; Gilli Galore; Gad Rennert; Flavio Lejbkowicz; Leon Raskin; Irene L Andrulis; Eduard Ilyushik; Hilmi Ozcelik; Peter Devilee; Maaike P G Vreeswijk; Mark H Greene; Sheila A Prindiville; Ana Osorio; Javier Benitez; Michal Zikan; Csilla I Szabo; Outi Kilpivaara; Heli Nevanlinna; Ute Hamann; Francine Durocher; Adalgeir Arason; Fergus J Couch; Douglas F Easton; Georgia Chenevix-Trench
Journal:  Am J Hum Genet       Date:  2007-10-16       Impact factor: 11.025

2.  Prevention and screening in BRCA mutation carriers and other breast/ovarian hereditary cancer syndromes: ESMO Clinical Practice Guidelines for cancer prevention and screening.

Authors:  S Paluch-Shimon; F Cardoso; C Sessa; J Balmana; M J Cardoso; F Gilbert; E Senkus
Journal:  Ann Oncol       Date:  2016-09       Impact factor: 32.976

Review 3.  Epidemiology of male breast cancer.

Authors:  Joli R Weiss; Kirsten B Moysich; Helen Swede
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2005-01       Impact factor: 4.254

4.  Cancer risks in two large breast cancer families linked to BRCA2 on chromosome 13q12-13.

Authors:  D F Easton; L Steele; P Fields; W Ormiston; D Averill; P A Daly; R McManus; S L Neuhausen; D Ford; R Wooster; L A Cannon-Albright; M R Stratton; D E Goldgar
Journal:  Am J Hum Genet       Date:  1997-07       Impact factor: 11.025

5.  Variation in cancer risks, by mutation position, in BRCA2 mutation carriers.

Authors:  D Thompson; D Easton
Journal:  Am J Hum Genet       Date:  2001-01-19       Impact factor: 11.025

Review 6.  Cancer risks for male carriers of germline mutations in BRCA1 or BRCA2: a review of the literature.

Authors:  Alexander Liede; Beth Y Karlan; Steven A Narod
Journal:  J Clin Oncol       Date:  2004-02-15       Impact factor: 44.544

7.  Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Authors:  Nasim Mavaddat; Kyriaki Michailidou; Joe Dennis; Michael Lush; Laura Fachal; Andrew Lee; Jonathan P Tyrer; Ting-Huei Chen; Qin Wang; Manjeet K Bolla; Xin Yang; Muriel A Adank; Thomas Ahearn; Kristiina Aittomäki; Jamie Allen; Irene L Andrulis; Hoda Anton-Culver; Natalia N Antonenkova; Volker Arndt; Kristan J Aronson; Paul L Auer; Päivi Auvinen; Myrto Barrdahl; Laura E Beane Freeman; Matthias W Beckmann; Sabine Behrens; Javier Benitez; Marina Bermisheva; Leslie Bernstein; Carl Blomqvist; Natalia V Bogdanova; Stig E Bojesen; Bernardo Bonanni; Anne-Lise Børresen-Dale; Hiltrud Brauch; Michael Bremer; Hermann Brenner; Adam Brentnall; Ian W Brock; Angela Brooks-Wilson; Sara Y Brucker; Thomas Brüning; Barbara Burwinkel; Daniele Campa; Brian D Carter; Jose E Castelao; Stephen J Chanock; Rowan Chlebowski; Hans Christiansen; Christine L Clarke; J Margriet Collée; Emilie Cordina-Duverger; Sten Cornelissen; Fergus J Couch; Angela Cox; Simon S Cross; Kamila Czene; Mary B Daly; Peter Devilee; Thilo Dörk; Isabel Dos-Santos-Silva; Martine Dumont; Lorraine Durcan; Miriam Dwek; Diana M Eccles; Arif B Ekici; A Heather Eliassen; Carolina Ellberg; Christoph Engel; Mikael Eriksson; D Gareth Evans; Peter A Fasching; Jonine Figueroa; Olivia Fletcher; Henrik Flyger; Asta Försti; Lin Fritschi; Marike Gabrielson; Manuela Gago-Dominguez; Susan M Gapstur; José A García-Sáenz; Mia M Gaudet; Vassilios Georgoulias; Graham G Giles; Irina R Gilyazova; Gord Glendon; Mark S Goldberg; David E Goldgar; Anna González-Neira; Grethe I Grenaker Alnæs; Mervi Grip; Jacek Gronwald; Anne Grundy; Pascal Guénel; Lothar Haeberle; Eric Hahnen; Christopher A Haiman; Niclas Håkansson; Ute Hamann; Susan E Hankinson; Elaine F Harkness; Steven N Hart; Wei He; Alexander Hein; Jane Heyworth; Peter Hillemanns; Antoinette Hollestelle; Maartje J Hooning; Robert N Hoover; John L Hopper; Anthony Howell; Guanmengqian Huang; Keith Humphreys; David J Hunter; Milena Jakimovska; Anna Jakubowska; Wolfgang Janni; Esther M John; Nichola Johnson; Michael E Jones; Arja Jukkola-Vuorinen; Audrey Jung; Rudolf Kaaks; Katarzyna Kaczmarek; Vesa Kataja; Renske Keeman; Michael J Kerin; Elza Khusnutdinova; Johanna I Kiiski; Julia A Knight; Yon-Dschun Ko; Veli-Matti Kosma; Stella Koutros; Vessela N Kristensen; Ute Krüger; Tabea Kühl; Diether Lambrechts; Loic Le Marchand; Eunjung Lee; Flavio Lejbkowicz; Jenna Lilyquist; Annika Lindblom; Sara Lindström; Jolanta Lissowska; Wing-Yee Lo; Sibylle Loibl; Jirong Long; Jan Lubiński; Michael P Lux; Robert J MacInnis; Tom Maishman; Enes Makalic; Ivana Maleva Kostovska; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; John W M Martens; Maria Elena Martinez; Dimitrios Mavroudis; Catriona McLean; Alfons Meindl; Usha Menon; Pooja Middha; Nicola Miller; Fernando Moreno; Anna Marie Mulligan; Claire Mulot; Victor M Muñoz-Garzon; Susan L Neuhausen; Heli Nevanlinna; Patrick Neven; William G Newman; Sune F Nielsen; Børge G Nordestgaard; Aaron Norman; Kenneth Offit; Janet E Olson; Håkan Olsson; Nick Orr; V Shane Pankratz; Tjoung-Won Park-Simon; Jose I A Perez; Clara Pérez-Barrios; Paolo Peterlongo; Julian Peto; Mila Pinchev; Dijana Plaseska-Karanfilska; Eric C Polley; Ross Prentice; Nadege Presneau; Darya Prokofyeva; Kristen Purrington; Katri Pylkäs; Brigitte Rack; Paolo Radice; Rohini Rau-Murthy; Gad Rennert; Hedy S Rennert; Valerie Rhenius; Mark Robson; Atocha Romero; Kathryn J Ruddy; Matthias Ruebner; Emmanouil Saloustros; Dale P Sandler; Elinor J Sawyer; Daniel F Schmidt; Rita K Schmutzler; Andreas Schneeweiss; Minouk J Schoemaker; Fredrick Schumacher; Peter Schürmann; Lukas Schwentner; Christopher Scott; Rodney J Scott; Caroline Seynaeve; Mitul Shah; Mark E Sherman; Martha J Shrubsole; Xiao-Ou Shu; Susan Slager; Ann Smeets; Christof Sohn; Penny Soucy; Melissa C Southey; John J Spinelli; Christa Stegmaier; Jennifer Stone; Anthony J Swerdlow; Rulla M Tamimi; William J Tapper; Jack A Taylor; Mary Beth Terry; Kathrin Thöne; Rob A E M Tollenaar; Ian Tomlinson; Thérèse Truong; Maria Tzardi; Hans-Ulrich Ulmer; Michael Untch; Celine M Vachon; Elke M van Veen; Joseph Vijai; Clarice R Weinberg; Camilla Wendt; Alice S Whittemore; Hans Wildiers; Walter Willett; Robert Winqvist; Alicja Wolk; Xiaohong R Yang; Drakoulis Yannoukakos; Yan Zhang; Wei Zheng; Argyrios Ziogas; Alison M Dunning; Deborah J Thompson; Georgia Chenevix-Trench; Jenny Chang-Claude; Marjanka K Schmidt; Per Hall; Roger L Milne; Paul D P Pharoah; Antonis C Antoniou; Nilanjan Chatterjee; Peter Kraft; Montserrat García-Closas; Jacques Simard; Douglas F Easton
Journal:  Am J Hum Genet       Date:  2018-12-13       Impact factor: 11.025

8.  Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

Authors:  Roger L Milne; Karoline B Kuchenbaecker; Kyriaki Michailidou; Jonathan Beesley; Siddhartha Kar; Sara Lindström; Shirley Hui; Audrey Lemaçon; Penny Soucy; Joe Dennis; Xia Jiang; Asha Rostamianfar; Hilary Finucane; Manjeet K Bolla; Lesley McGuffog; Qin Wang; Cora M Aalfs; Marcia Adams; Julian Adlard; Simona Agata; Shahana Ahmed; Habibul Ahsan; Kristiina Aittomäki; Fares Al-Ejeh; Jamie Allen; Christine B Ambrosone; Christopher I Amos; Irene L Andrulis; Hoda Anton-Culver; Natalia N Antonenkova; Volker Arndt; Norbert Arnold; Kristan J Aronson; Bernd Auber; Paul L Auer; Margreet G E M Ausems; Jacopo Azzollini; François Bacot; Judith Balmaña; Monica Barile; Laure Barjhoux; Rosa B Barkardottir; Myrto Barrdahl; Daniel Barnes; Daniel Barrowdale; Caroline Baynes; Matthias W Beckmann; Javier Benitez; Marina Bermisheva; Leslie Bernstein; Yves-Jean Bignon; Kathleen R Blazer; Marinus J Blok; Carl Blomqvist; William Blot; Kristie Bobolis; Bram Boeckx; Natalia V Bogdanova; Anders Bojesen; Stig E Bojesen; Bernardo Bonanni; Anne-Lise Børresen-Dale; Aniko Bozsik; Angela R Bradbury; Judith S Brand; Hiltrud Brauch; Hermann Brenner; Brigitte Bressac-de Paillerets; Carole Brewer; Louise Brinton; Per Broberg; Angela Brooks-Wilson; Joan Brunet; Thomas Brüning; Barbara Burwinkel; Saundra S Buys; Jinyoung Byun; Qiuyin Cai; Trinidad Caldés; Maria A Caligo; Ian Campbell; Federico Canzian; Olivier Caron; Angel Carracedo; Brian D Carter; J Esteban Castelao; Laurent Castera; Virginie Caux-Moncoutier; Salina B Chan; Jenny Chang-Claude; Stephen J Chanock; Xiaoqing Chen; Ting-Yuan David Cheng; Jocelyne Chiquette; Hans Christiansen; Kathleen B M Claes; Christine L Clarke; Thomas Conner; Don M Conroy; Jackie Cook; Emilie Cordina-Duverger; Sten Cornelissen; Isabelle Coupier; Angela Cox; David G Cox; Simon S Cross; Katarina Cuk; Julie M Cunningham; Kamila Czene; Mary B Daly; Francesca Damiola; Hatef Darabi; Rosemarie Davidson; Kim De Leeneer; Peter Devilee; Ed Dicks; Orland Diez; Yuan Chun Ding; Nina Ditsch; Kimberly F Doheny; Susan M Domchek; Cecilia M Dorfling; Thilo Dörk; Isabel Dos-Santos-Silva; Stéphane Dubois; Pierre-Antoine Dugué; Martine Dumont; Alison M Dunning; Lorraine Durcan; Miriam Dwek; Bernd Dworniczak; Diana Eccles; Ros Eeles; Hans Ehrencrona; Ursula Eilber; Bent Ejlertsen; Arif B Ekici; A Heather Eliassen; Christoph Engel; Mikael Eriksson; Laura Fachal; Laurence Faivre; Peter A Fasching; Ulrike Faust; Jonine Figueroa; Dieter Flesch-Janys; Olivia Fletcher; Henrik Flyger; William D Foulkes; Eitan Friedman; Lin Fritschi; Debra Frost; Marike Gabrielson; Pragna Gaddam; Marilie D Gammon; Patricia A Ganz; Susan M Gapstur; Judy Garber; Vanesa Garcia-Barberan; José A García-Sáenz; Mia M Gaudet; Marion Gauthier-Villars; Andrea Gehrig; Vassilios Georgoulias; Anne-Marie Gerdes; Graham G Giles; Gord Glendon; Andrew K Godwin; Mark S Goldberg; David E Goldgar; Anna González-Neira; Paul Goodfellow; Mark H Greene; Grethe I Grenaker Alnæs; Mervi Grip; Jacek Gronwald; Anne Grundy; Daphne Gschwantler-Kaulich; Pascal Guénel; Qi Guo; Lothar Haeberle; Eric Hahnen; Christopher A Haiman; Niclas Håkansson; Emily Hallberg; Ute Hamann; Nathalie Hamel; Susan Hankinson; Thomas V O Hansen; Patricia Harrington; Steven N Hart; Jaana M Hartikainen; Catherine S Healey; Alexander Hein; Sonja Helbig; Alex Henderson; Jane Heyworth; Belynda Hicks; Peter Hillemanns; Shirley Hodgson; Frans B Hogervorst; Antoinette Hollestelle; Maartje J Hooning; Bob Hoover; John L Hopper; Chunling Hu; Guanmengqian Huang; Peter J Hulick; Keith Humphreys; David J Hunter; Evgeny N Imyanitov; Claudine Isaacs; Motoki Iwasaki; Louise Izatt; Anna Jakubowska; Paul James; Ramunas Janavicius; Wolfgang Janni; Uffe Birk Jensen; Esther M John; Nichola Johnson; Kristine Jones; Michael Jones; Arja Jukkola-Vuorinen; Rudolf Kaaks; Maria Kabisch; Katarzyna Kaczmarek; Daehee Kang; Karin Kast; Renske Keeman; Michael J Kerin; Carolien M Kets; Machteld Keupers; Sofia Khan; Elza Khusnutdinova; Johanna I Kiiski; Sung-Won Kim; Julia A Knight; Irene Konstantopoulou; Veli-Matti Kosma; Vessela N Kristensen; Torben A Kruse; Ava Kwong; Anne-Vibeke Lænkholm; Yael Laitman; Fiona Lalloo; Diether Lambrechts; Keren Landsman; Christine Lasset; Conxi Lazaro; Loic Le Marchand; Julie Lecarpentier; Andrew Lee; Eunjung Lee; Jong Won Lee; Min Hyuk Lee; Flavio Lejbkowicz; Fabienne Lesueur; Jingmei Li; Jenna Lilyquist; Anne Lincoln; Annika Lindblom; Jolanta Lissowska; Wing-Yee Lo; Sibylle Loibl; Jirong Long; Jennifer T Loud; Jan Lubinski; Craig Luccarini; Michael Lush; Robert J MacInnis; Tom Maishman; Enes Makalic; Ivana Maleva Kostovska; Kathleen E Malone; Siranoush Manoukian; JoAnn E Manson; Sara Margolin; John W M Martens; Maria Elena Martinez; Keitaro Matsuo; Dimitrios Mavroudis; Sylvie Mazoyer; Catriona McLean; Hanne Meijers-Heijboer; Primitiva Menéndez; Jeffery Meyer; Hui Miao; Austin Miller; Nicola Miller; Gillian Mitchell; Marco Montagna; Kenneth Muir; Anna Marie Mulligan; Claire Mulot; Sue Nadesan; Katherine L Nathanson; Susan L Neuhausen; Heli Nevanlinna; Ines Nevelsteen; Dieter Niederacher; Sune F Nielsen; Børge G Nordestgaard; Aaron Norman; Robert L Nussbaum; Edith Olah; Olufunmilayo I Olopade; Janet E Olson; Curtis Olswold; Kai-Ren Ong; Jan C Oosterwijk; Nick Orr; Ana Osorio; V Shane Pankratz; Laura Papi; Tjoung-Won Park-Simon; Ylva Paulsson-Karlsson; Rachel Lloyd; Inge Søkilde Pedersen; Bernard Peissel; Ana Peixoto; Jose I A Perez; Paolo Peterlongo; Julian Peto; Georg Pfeiler; Catherine M Phelan; Mila Pinchev; Dijana Plaseska-Karanfilska; Bruce Poppe; Mary E Porteous; Ross Prentice; Nadege Presneau; Darya Prokofieva; Elizabeth Pugh; Miquel Angel Pujana; Katri Pylkäs; Brigitte Rack; Paolo Radice; Nazneen Rahman; Johanna Rantala; Christine Rappaport-Fuerhauser; Gad Rennert; Hedy S Rennert; Valerie Rhenius; Kerstin Rhiem; Andrea Richardson; Gustavo C Rodriguez; Atocha Romero; Jane Romm; Matti A Rookus; Anja Rudolph; Thomas Ruediger; Emmanouil Saloustros; Joyce Sanders; Dale P Sandler; Suleeporn Sangrajrang; Elinor J Sawyer; Daniel F Schmidt; Minouk J Schoemaker; Fredrick Schumacher; Peter Schürmann; Lukas Schwentner; Christopher Scott; Rodney J Scott; Sheila Seal; Leigha Senter; Caroline Seynaeve; Mitul Shah; Priyanka Sharma; Chen-Yang Shen; Xin Sheng; Hermela Shimelis; Martha J Shrubsole; Xiao-Ou Shu; Lucy E Side; Christian F Singer; Christof Sohn; Melissa C Southey; John J Spinelli; Amanda B Spurdle; Christa Stegmaier; Dominique Stoppa-Lyonnet; Grzegorz Sukiennicki; Harald Surowy; Christian Sutter; Anthony Swerdlow; Csilla I Szabo; Rulla M Tamimi; Yen Y Tan; Jack A Taylor; Maria-Isabel Tejada; Maria Tengström; Soo H Teo; Mary B Terry; Daniel C Tessier; Alex Teulé; Kathrin Thöne; Darcy L Thull; Maria Grazia Tibiletti; Laima Tihomirova; Marc Tischkowitz; Amanda E Toland; Rob A E M Tollenaar; Ian Tomlinson; Ling Tong; Diana Torres; Martine Tranchant; Thérèse Truong; Kathy Tucker; Nadine Tung; Jonathan Tyrer; Hans-Ulrich Ulmer; Celine Vachon; Christi J van Asperen; David Van Den Berg; Ans M W van den Ouweland; Elizabeth J van Rensburg; Liliana Varesco; Raymonda Varon-Mateeva; Ana Vega; Alessandra Viel; Joseph Vijai; Daniel Vincent; Jason Vollenweider; Lisa Walker; Zhaoming Wang; Shan Wang-Gohrke; Barbara Wappenschmidt; Clarice R Weinberg; Jeffrey N Weitzel; Camilla Wendt; Jelle Wesseling; Alice S Whittemore; Juul T Wijnen; Walter Willett; Robert Winqvist; Alicja Wolk; Anna H Wu; Lucy Xia; Xiaohong R Yang; Drakoulis Yannoukakos; Daniela Zaffaroni; Wei Zheng; Bin Zhu; Argyrios Ziogas; Elad Ziv; Kristin K Zorn; Manuela Gago-Dominguez; Arto Mannermaa; Håkan Olsson; Manuel R Teixeira; Jennifer Stone; Kenneth Offit; Laura Ottini; Sue K Park; Mads Thomassen; Per Hall; Alfons Meindl; Rita K Schmutzler; Arnaud Droit; Gary D Bader; Paul D P Pharoah; Fergus J Couch; Douglas F Easton; Peter Kraft; Georgia Chenevix-Trench; Montserrat García-Closas; Marjanka K Schmidt; Antonis C Antoniou; Jacques Simard
Journal:  Nat Genet       Date:  2017-10-23       Impact factor: 38.330

9.  Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers.

Authors:  Karoline B Kuchenbaecker; John L Hopper; Daniel R Barnes; Kelly-Anne Phillips; Thea M Mooij; Marie-José Roos-Blom; Sarah Jervis; Flora E van Leeuwen; Roger L Milne; Nadine Andrieu; David E Goldgar; Mary Beth Terry; Matti A Rookus; Douglas F Easton; Antonis C Antoniou; Lesley McGuffog; D Gareth Evans; Daniel Barrowdale; Debra Frost; Julian Adlard; Kai-Ren Ong; Louise Izatt; Marc Tischkowitz; Ros Eeles; Rosemarie Davidson; Shirley Hodgson; Steve Ellis; Catherine Nogues; Christine Lasset; Dominique Stoppa-Lyonnet; Jean-Pierre Fricker; Laurence Faivre; Pascaline Berthet; Maartje J Hooning; Lizet E van der Kolk; Carolien M Kets; Muriel A Adank; Esther M John; Wendy K Chung; Irene L Andrulis; Melissa Southey; Mary B Daly; Saundra S Buys; Ana Osorio; Christoph Engel; Karin Kast; Rita K Schmutzler; Trinidad Caldes; Anna Jakubowska; Jacques Simard; Michael L Friedlander; Sue-Anne McLachlan; Eva Machackova; Lenka Foretova; Yen Y Tan; Christian F Singer; Edith Olah; Anne-Marie Gerdes; Brita Arver; Håkan Olsson
Journal:  JAMA       Date:  2017-06-20       Impact factor: 56.272

Review 10.  Male breast cancer: genetics, epigenetics, and ethical aspects.

Authors:  P Rizzolo; V Silvestri; S Tommasi; R Pinto; K Danza; M Falchetti; M Gulino; P Frati; L Ottini
Journal:  Ann Oncol       Date:  2013-11       Impact factor: 32.976
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  5 in total

Review 1.  Germline genetics of prostate cancer.

Authors:  Hiba M Khan; Heather H Cheng
Journal:  Prostate       Date:  2022-08       Impact factor: 4.012

2.  Prevalence of Cancer Predisposition Germline Variants in Male Breast Cancer Patients: Results of the German Consortium for Hereditary Breast and Ovarian Cancer.

Authors:  Muriel Rolfes; Julika Borde; Kathrin Möllenhoff; Mohamad Kayali; Corinna Ernst; Andrea Gehrig; Christian Sutter; Juliane Ramser; Dieter Niederacher; Judit Horváth; Norbert Arnold; Alfons Meindl; Bernd Auber; Andreas Rump; Shan Wang-Gohrke; Julia Ritter; Julia Hentschel; Holger Thiele; Janine Altmüller; Peter Nürnberg; Kerstin Rhiem; Christoph Engel; Barbara Wappenschmidt; Rita K Schmutzler; Eric Hahnen; Jan Hauke
Journal:  Cancers (Basel)       Date:  2022-07-05       Impact factor: 6.575

Review 3.  Precision intervention for prostate cancer: Re-evaluating who is at risk.

Authors:  Alexandros Papachristodoulou; Cory Abate-Shen
Journal:  Cancer Lett       Date:  2022-04-29       Impact factor: 9.756

Review 4.  Male Breast Cancer: From Molecular Genetics to Clinical Management.

Authors:  Matilde Pensabene; Claudia Von Arx; Michelino De Laurentiis
Journal:  Cancers (Basel)       Date:  2022-04-15       Impact factor: 6.575

Review 5.  An appraisal of genetic testing for prostate cancer susceptibility.

Authors:  Amy Finch; Roderick Clark; Danny Vesprini; Justin Lorentz; Raymond H Kim; Emily Thain; Neil Fleshner; Mohammad R Akbari; Cezary Cybulski; Steven A Narod
Journal:  NPJ Precis Oncol       Date:  2022-06-22
  5 in total

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