Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Monohydroperoxides of linoleic acid in endoplasmic lipids of rats exposed to tetrachloromethane.

Literature DB >> 3431344

Monohydroperoxides of linoleic acid in endoplasmic lipids of rats exposed to tetrachloromethane.

H Frank¹, M Wiegand, M Strecker, D Thiel.

Abstract

An accurate method for the quantitative determination of hydroperoxy and hydroxy fatty acids in liver microsomes is presented which involves the use of 18O-labeled internal standards. The method is employed for the determination of hydroperoxides in rat liver microsomes after aerobic incubation with Fe2+/ADP and in microsomes from animals exposed to 75 mg tetrachloromethane/kg body weight. The amounts found after artificial microsomal "lipid peroxidation" are almost two orders of magnitude larger than those in microsomes from tetrachloromethane-exposed animals.

Entities: Chemical Species

Mesh：

Substances：

Year: 1987 PMID： 3431344 DOI： 10.1007/BF02533967

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

34 in total

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

Authors: T OMURA; R SATO
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

2. The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents.

Authors: K M WILBUR; F BERNHEIM; O W SHAPIRO
Journal: Arch Biochem Date: 1949-12

3. Determination of alkanes in breath to monitor lipid peroxidation in the presence of volatile toxicants and metabolites. An optimized, automatic method.

Authors: H Frank; H Dürk
Journal: Arch Toxicol Date: 1983-07 Impact factor: 5.153

4. Binding of 14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3 by reduced liver microsomes.

Authors: H Uehleke; K H Hellmer; S Tabarelli
Journal: Xenobiotica Date: 1973-01 Impact factor: 1.908

5. Tetrachloromethane metabolism in vivo under normoxia and hypoxia. Biochemical and histopathological effects relative to alkane exhalation.

Authors: H Dürk; C Klessen; H Frank
Journal: Arch Toxicol Date: 1987 Impact factor: 5.153

6. Metabolism of [14C]carbon tetrachloride to exhaled, excreted and bound metabolites. Dose-response, time-course and pharmacokinetics.

Authors: E S Reynolds; R J Treinen; H H Farrish; M T Moslen
Journal: Biochem Pharmacol Date: 1984-11-01 Impact factor: 5.858

7. Autoxidation of methyl linoleate. Separation and analysis of isomeric mixtures of methyl linoleate hydroperoxides and methyl hydroxylinoleates.

Authors: H W Chan; G Levett
Journal: Lipids Date: 1977-01 Impact factor: 1.880

Monohydroperoxides of linoleic acid in endoplasmic lipids of rats exposed to tetrachloromethane.

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

2. The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents.

3. Determination of alkanes in breath to monitor lipid peroxidation in the presence of volatile toxicants and metabolites. An optimized, automatic method.

4. Binding of 14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3 by reduced liver microsomes.

5. Tetrachloromethane metabolism in vivo under normoxia and hypoxia. Biochemical and histopathological effects relative to alkane exhalation.

6. Metabolism of [14C]carbon tetrachloride to exhaled, excreted and bound metabolites. Dose-response, time-course and pharmacokinetics.

7. Autoxidation of methyl linoleate. Separation and analysis of isomeric mixtures of methyl linoleate hydroperoxides and methyl hydroxylinoleates.

8. Enhanced lipid peroxidation in liver microsomes of zinc-deficient rats.

9. Peroxidation of subcellular organelles: formation of lipofuscinlike fluorescent pigments.

10. Effect of hydrogen peroxide on the initiation of microsomal lipid peroxidation.

1. Mass spectrometric detection of cross-linked fatty acids formed during radical-induced lesion of lipid membranes.