OBJECTIVE: To investigate the curative effects of montmorillonite powder combined with dexamethasone on acute radiation enteritis. METHODS:Eighty-six patients with acute radiation enteritis were enrolled in this prospective research, and they were divided into a control group and an intervention group using a random number table, with 43 cases in each group. Patients in both groups received conventional treatment. The control group was treated with montmorillonite powder, and the intervention group was treated with retention enema with dexamethasone based on montmorillonite powder. The grades of mucosal damage, changes in cytokine levels, the efficacy of colonoscopy, and overall curative effects of the two groups before and after treatment were observed. RESULTS: After treatment, the levels of IL-2 and IFN-γ of the two groups were significantly reduced, and the level of IL-10 was significantly increased. The intervention group was significantly better than the control group (all P<0.001). The grades of mucosal damage in the intervention group showed better improvement than that in the control group (P<0.01), and the overall curative effects in the intervention group were significantly better than those in the control group (both P<0.05). CONCLUSION:Montmorillonite powder combined with dexamethasone is effective in treating patients with acute radiation enteritis, which can effectively alleviate mucosal damage, improve inflammation, and promote patient recovery. It has the value of promotion and application. AJTR
RCT Entities:
OBJECTIVE: To investigate the curative effects of montmorillonite powder combined with dexamethasone on acute radiation enteritis. METHODS: Eighty-six patients with acute radiation enteritis were enrolled in this prospective research, and they were divided into a control group and an intervention group using a random number table, with 43 cases in each group. Patients in both groups received conventional treatment. The control group was treated with montmorillonite powder, and the intervention group was treated with retention enema with dexamethasone based on montmorillonite powder. The grades of mucosal damage, changes in cytokine levels, the efficacy of colonoscopy, and overall curative effects of the two groups before and after treatment were observed. RESULTS: After treatment, the levels of IL-2 and IFN-γ of the two groups were significantly reduced, and the level of IL-10 was significantly increased. The intervention group was significantly better than the control group (all P<0.001). The grades of mucosal damage in the intervention group showed better improvement than that in the control group (P<0.01), and the overall curative effects in the intervention group were significantly better than those in the control group (both P<0.05). CONCLUSION:Montmorillonite powder combined with dexamethasone is effective in treating patients with acute radiation enteritis, which can effectively alleviate mucosal damage, improve inflammation, and promote patient recovery. It has the value of promotion and application. AJTR
Authors: Zoran Stojcev; Łukasz Krokowicz; Piotr Krokowicz; Marek Szczepkowski; Katarzyna Borycka-Kiciak; Adam Kiciak; Jarosław Walkowiak; Michał Drews; Tomasz Banasiewicz Journal: Int J Colorectal Dis Date: 2013-03-21 Impact factor: 2.571