Lina Lu1,2, Wenjun Li3,4, Lihua Chen2, Qiong Su2, Yanbin Wang2, Zhong Guo5, Yongjuan Lu2, Bin Liu1,6, Song Qin3,4. 1. School of Nuclear Science & Technology, Lanzhou University, Lanzhou 730000, Gansu, PR China. 2. School of Chemical Engineering, Northwest Minzu University, Lanzhou 730000, Gansu, PR China. 3. Key Laboratory of Biology & Bioresource Utilization, Yantai Institute of Costal Zone Research, Chinese Academy of Sciences, Yantai 264003, PR China. 4. Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, PR China. 5. Medical College of Northwest Minzu University, Lanzhou 730000, Gansu, PR China. 6. School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu, PR China.
Abstract
Aim: To systematically review the prophylactic and therapeutic interventions for reducing the incidence or severity of intestinal symptoms among cancer patients receiving radiotherapy. Materials & methods: A literature search was conducted in the PubMed database using various search terms, including 'radiation enteritis', 'radiation enteropathy', 'radiation-induced intestinal disease', 'radiation-induced intestinal damage' and 'radiation mucositis'. The search was limited to in vivo studies, clinical trials and meta-analyses published in English with no limitation on publication date. Other relevant literature was identified based on the reference lists of selected studies. Results: The pathogenesis of acute and chronic radiation-induced intestinal damage as well as the prevention and treatment approaches were reviewed. Conclusion: There is inadequate evidence to strongly support the use of a particular strategy to reduce radiation-induced intestinal damage. More high-quality randomized controlled trials are required for interventions with limited evidence suggestive of potential benefits.
Aim: To systematically review the prophylactic and therapeutic interventions for reducing the incidence or severity of intestinal symptoms among cancerpatients receiving radiotherapy. Materials & methods: A literature search was conducted in the PubMed database using various search terms, including 'radiation enteritis', 'radiation enteropathy', 'radiation-induced intestinal disease', 'radiation-induced intestinal damage' and 'radiation mucositis'. The search was limited to in vivo studies, clinical trials and meta-analyses published in English with no limitation on publication date. Other relevant literature was identified based on the reference lists of selected studies. Results: The pathogenesis of acute and chronic radiation-induced intestinal damage as well as the prevention and treatment approaches were reviewed. Conclusion: There is inadequate evidence to strongly support the use of a particular strategy to reduce radiation-induced intestinal damage. More high-quality randomized controlled trials are required for interventions with limited evidence suggestive of potential benefits.
Authors: Tao Yan; Shun Guo; Tian Zhang; Zhimin Zhang; An Liu; Song Zhang; Yuan Xu; Yuhong Qi; Weihe Zhao; Qinhui Wang; Lei Shi; Linna Liu Journal: Front Pharmacol Date: 2021-04-22 Impact factor: 5.810
Authors: Chola Mulenga; Sanja Sviben; Kanta Chandwe; Beatrice Amadi; Violet Kayamba; James A J Fitzpatrick; Victor Mudenda; Paul Kelly Journal: Front Med (Lausanne) Date: 2022-03-16
Authors: Dong-Ming Wu; Jing Li; Rong Shen; Jin Li; Ye Yu; Li Li; Shi-Hua Deng; Teng Liu; Ting Zhang; Ying Xu; De-Gui Wang Journal: Front Pharmacol Date: 2022-01-18 Impact factor: 5.810