Literature DB >> 34280022

Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine, and Linezolid in a Murine Model of Tuberculosis.

Wei Yu1,2,3, Buhari Yusuf1,2,3, Shuai Wang1,2,3, Xirong Tian1,2,4, H M Adnan Hameed1,2, Zhili Lu1,2, Gift Chiwala1,2,3, Md Shah Alam1,2,3, Gregory M Cook5,6, Dmitry A Maslov7, Nanshan Zhong2,8, Tianyu Zhang1,2,3.   

Abstract

TB47, a new drug candidate targeting QcrB in the electron transport chain, has shown a unique synergistic activity with clofazimine and forms a highly sterilizing combination. Here, we investigated the sterilizing effects of several all-oral regimens containing TB47 plus clofazimine and linezolid as a block and the roles of fluoroquinolones and pyrazinamide in them. All these regimens cured tuberculosis within 4 to 6 months in a well-established mouse model, and adding pyrazinamide showed a significant difference in bactericidal effects.

Entities:  

Keywords:  TB47; cytochrome bc1-aa3 oxidase; drug resistance; murine model; tuberculosis

Mesh：

Substances：

Year:  2021        PMID： 34280022      PMCID： PMC8448087          DOI： 10.1128/AAC.00706-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.

Authors:  Francesca Conradie; Andreas H Diacon; Nosipho Ngubane; Pauline Howell; Daniel Everitt; Angela M Crook; Carl M Mendel; Erica Egizi; Joanna Moreira; Juliano Timm; Timothy D McHugh; Genevieve H Wills; Anna Bateson; Robert Hunt; Christo Van Niekerk; Mengchun Li; Morounfolu Olugbosi; Melvin Spigelman
Journal:  N Engl J Med       Date:  2020-03-05       Impact factor: 91.245

2.  Assessment of Clofazimine and TB47 Combination Activity against Mycobacterium abscessus Using a Bioluminescent Approach.

Authors:  Yang Liu; Yaoju Tan; M Mahmudul Islam; Yuanyuan Cao; Xiaoyun Lu; Sheng Zeng; H M Adnan Hameed; Peipei Zhou; Xingshan Cai; Shuai Wang; Julius N Mugweru; Guoliang Zhang; Huancai Yin; Jianxiong Liu; Eric Nuermberger; Tianyu Zhang
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191

3.  Pyrazinamide Resistance and Mutation Patterns Among Multidrug-Resistant Mycobacterium tuberculosis from Henan Province.

Authors:  Jie Shi; Ruyue Su; Danwei Zheng; Yankun Zhu; Xiaoguang Ma; Shaohua Wang; Hui Li; Dingyong Sun
Journal:  Infect Drug Resist       Date:  2020-08-20       Impact factor: 4.003

4.  The immunosuppressive effects of dexamethasone administered in drinking water to C57BL/6N mice infected with Cryptosporidium parvum.

Authors:  S Yang; M C Healey
Journal:  J Parasitol       Date:  1993-08       Impact factor: 1.276

5.  Combinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis.

Authors:  Bryan J Berube; Tanya Parish
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

6.  Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors.

Authors:  Bryan J Berube; Dara Russell; Lina Castro; Seoung-Ryoung Choi; Prabagaran Narayanasamy; Tanya Parish
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

7.  Corticosteroid-induced immunosuppression ultimately does not compromise the efficacy of antibiotherapy in murine Mycobacterium ulcerans infection.

Authors:  Teresa G Martins; Gabriela Trigo; Alexandra G Fraga; José B Gama; Adhemar Longatto-Filho; Margarida Saraiva; Manuel T Silva; António G Castro; Jorge Pedrosa
Journal:  PLoS Negl Trop Dis       Date:  2012-11-29

8.  The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model.

Authors:  Yang Liu; Yamin Gao; Jianxiong Liu; Yaoju Tan; Zhiyong Liu; Chiranjibi Chhotaray; Huofeng Jiang; Zhili Lu; Gift Chiwala; Shuai Wang; Gaelle Makafe; Md Mahmudul Islam; H M Adnan Hameed; Xingshan Cai; Changwei Wang; Xinjie Li; Shouyong Tan; Tianyu Zhang
Journal:  Nat Commun       Date:  2019-01-31       Impact factor: 14.919

9.  Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China.

Authors:  Hm Adnan Hameed; Yaoju Tan; Md Mahmudul Islam; Zhili Lu; Chiranjibi Chhotaray; Shuai Wang; Zhiyong Liu; Cuiting Fang; Shouyong Tan; Wing Wai Yew; Nanshan Zhong; Jianxiong Liu; Tianyu Zhang
Journal:  Infect Drug Resist       Date:  2020-01-22       Impact factor: 4.003
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  2 in total

Review 1.  Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis.

Authors:  Matthew B McNeil; Chen-Yi Cheung; Natalie J E Waller; Cara Adolph; Cassandra L Chapman; Noon E J Seeto; William Jowsey; Zhengqiu Li; H M Adnan Hameed; Tianyu Zhang; Gregory M Cook
Journal:  Front Cell Infect Microbiol       Date:  2022-08-24       Impact factor: 6.073

2.  Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine, and Linezolid in a Murine Model of Tuberculosis.

Authors:  Wei Yu; Buhari Yusuf; Shuai Wang; Xirong Tian; H M Adnan Hameed; Zhili Lu; Gift Chiwala; Md Shah Alam; Gregory M Cook; Dmitry A Maslov; Nanshan Zhong; Tianyu Zhang
Journal:  Antimicrob Agents Chemother       Date:  2021-07-19       Impact factor: 5.191
  2 in total

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