Literature DB >> 3426563

The effects of recombinant tumour necrosis factor (cachectin) on metabolism in isolated rat adipocyte, hepatocyte and muscle preparations.

A M Rofe1, R A Conyers, R Bais, J R Gamble, M A Vadas.   

Abstract

Tumour necrosis factor (TNF) did not stimulate lipolysis in isolated rat adipocytes, though preincubation with TNF increased adrenaline-stimulated fatty acid release. Glycogenolysis, gluconeogenesis and ketogenesis in isolated rat hepatocytes were not influenced by TNF in short-term (30-60 min) incubations. TNF stimulated 14CO2 production from [U-14C]glucose in rat hemidiaphragm preparations, but lactate production and alanine release were not significantly altered. It is concluded that TNF does not regulate short-term metabolism in adipocytes, hepatocytes and muscle preparations in the manner of a catabolic hormone.

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Year:  1987        PMID： 3426563      PMCID： PMC1148481          DOI： 10.1042/bj2470789

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

1.  Cancer, ketosis and parenteral nutrition.

Authors:  R A Conyers; A G Need; T Durbridge; N D Harvey; N Potezny; A M Rofe
Journal:  Med J Aust       Date:  1979-05-05       Impact factor: 7.738

2.  The formation of alanine from amino acids in diaphragm muscle of the rat.

Authors:  L Goldstein; E A Newsholme
Journal:  Biochem J       Date:  1976-02-15       Impact factor: 3.857

Review 3.  Total parenteral nutrition in the cancer patient.

Authors:  M F Brennan
Journal:  N Engl J Med       Date:  1981-08-13       Impact factor: 91.245

Review 4.  Metabolic approaches to cancer cachexia.

Authors:  D H Lawson; A Richmond; D W Nixon; D Rudman
Journal:  Annu Rev Nutr       Date:  1982       Impact factor: 11.848

5.  The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.

Authors:  I C Kettelhut; W Fiers; A L Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

6.  The inhibition of malignant cell growth by ketone bodies.

Authors:  B A Magee; N Potezny; A M Rofe; R A Conyers
Journal:  Aust J Exp Biol Med Sci       Date:  1979-10

7.  Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

Authors:  J R Gamble; J M Harlan; S J Klebanoff; M A Vadas
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

8.  Mechanism for the 'anti-lipolytic' action of vasopressin in the starved rat.

Authors:  A M Rofe; D H Williamson
Journal:  Biochem J       Date:  1983-06-15       Impact factor: 3.857

9.  Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia.

Authors:  A M Rofe; D H Williamson
Journal:  Biochem J       Date:  1983-04-15       Impact factor: 3.857

10.  The metabolic response of tumour-bearing mice to fasting.

Authors:  A M Rofe; S J Porter; R Bais; R A Conyers
Journal:  Br J Cancer       Date:  1985-10       Impact factor: 7.640
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  13 in total

1.  Effect of recombinant human tumour necrosis factor alpha on protein synthesis in liver, skeletal muscle and skin of rats.

Authors:  Y Charters; R F Grimble
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

2.  Administration of endotoxin, tumor necrosis factor, or interleukin 1 to rats activates skeletal muscle branched-chain alpha-keto acid dehydrogenase.

Authors:  M D Nawabi; K P Block; M C Chakrabarti; M G Buse
Journal:  J Clin Invest       Date:  1990-01       Impact factor: 14.808

Review 3.  The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.

Authors:  O Friedrich; M B Reid; G Van den Berghe; I Vanhorebeek; G Hermans; M M Rich; L Larsson
Journal:  Physiol Rev       Date:  2015-07       Impact factor: 37.312

4.  Lipopolysaccharide (LPS) increases the in vivo oxidation of branched-chain amino acids in the rat: a cytokine-mediated effect.

Authors:  C García-Martínez; M Llovera; F J López-Soriano; B del Santo; J M Argilés
Journal:  Mol Cell Biochem       Date:  1995-07-05       Impact factor: 3.396

5.  Interleukin-6, but not tumour necrosis factor-alpha, increases lipogenesis in rat hepatocyte primary cultures.

Authors:  E P Brass; W H Vetter
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

6.  Hypoglycemia, hormones and cytokines in fatal meningococcal septicemia.

Authors:  J A Romijn; M H Godfried; C Wortel; H P Sauerwein
Journal:  J Endocrinol Invest       Date:  1990-10       Impact factor: 4.256

7.  Acute treatment with tumour necrosis factor-alpha induces changes in protein metabolism in rat skeletal muscle.

Authors:  C García-Martínez; F J López-Soriano; J M Argilés
Journal:  Mol Cell Biochem       Date:  1993-08-11       Impact factor: 3.396

8.  Effects of tumour necrosis factor-alpha (cachectin) on glucose metabolism in the rat. Intestinal absorption and isolated enterocyte metabolism.

Authors:  J Arbós; F J López-Soriano; N Carbó; J M Argilés
Journal:  Mol Cell Biochem       Date:  1992-05-13       Impact factor: 3.396

9.  Tumour necrosis factor alpha (cachectin) mimics some of the effects of tumour growth on the disposal of a [14C]lipid load in virgin, lactating and litter-removed rats.

Authors:  R D Evans; D H Williamson
Journal:  Biochem J       Date:  1988-12-15       Impact factor: 3.857

10.  Short-term effects of tumor necrosis factor on energy and substrate metabolism in dogs.

Authors:  Y Sakurai; X U Zhang; R R Wolfe
Journal:  J Clin Invest       Date:  1993-06       Impact factor: 14.808
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