Literature DB >> 34253247

Emerging SARS-CoV-2 variants of concern and potential intervention approaches.

Jasmin Khateeb1,2, Yuchong Li1,3, Haibo Zhang4,5,6.   

Abstract

The major variant of concerns (VOCs) have shared mutations in <span class="Species">severe acute respiratory syene">ndrome coronavirus 2 (<span class="Species">SARS-CoV-2) <span class="Gene">spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome. The spike protein mutations and other non-structural protein mutations in the VOCs may lead to escape approved vaccinations in certain extend. We will discuss these VOC mutations and discuss the need for combination therapeutic strategies targeting viral cycle and immune host responses.
© 2021. The Author(s).

Entities:  

Keywords:  B.1.1.7; B.1.351; P.1. B.1617.1; Transmissibility; Viral virulence

Year:  2021        PMID： 34253247     DOI： 10.1186/s13054-021-03662-x

Source DB:  PubMed          Journal:  Crit Care        ISSN： 1364-8535            Impact factor:   9.097


  8 in total

1.  Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo.

Authors:  Tao Tan; Jun Wu; Chenyang Si; Shaoxing Dai; Youyue Zhang; Nianqin Sun; E Zhang; Honglian Shao; Wei Si; Pengpeng Yang; Hong Wang; Zhenzhen Chen; Ran Zhu; Yu Kang; Reyna Hernandez-Benitez; Llanos Martinez Martinez; Estrella Nuñez Delicado; W Travis Berggren; May Schwarz; Zongyong Ai; Tianqing Li; Hongkui Deng; Concepcion Rodriguez Esteban; Weizhi Ji; Yuyu Niu; Juan Carlos Izpisua Belmonte
Journal:  Cell       Date:  2021-06-24       Impact factor: 41.582

2.  Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.

Authors:  Jun Lan; Jiwan Ge; Jinfang Yu; Sisi Shan; Huan Zhou; Shilong Fan; Qi Zhang; Xuanling Shi; Qisheng Wang; Linqi Zhang; Xinquan Wang
Journal:  Nature       Date:  2020-03-30       Impact factor: 49.962

3.  Spike mutation D614G alters SARS-CoV-2 fitness.

Authors:  Jessica A Plante; Yang Liu; Jianying Liu; Hongjie Xia; Bryan A Johnson; Kumari G Lokugamage; Xianwen Zhang; Antonio E Muruato; Jing Zou; Camila R Fontes-Garfias; Divya Mirchandani; Dionna Scharton; John P Bilello; Zhiqiang Ku; Zhiqiang An; Birte Kalveram; Alexander N Freiberg; Vineet D Menachery; Xuping Xie; Kenneth S Plante; Scott C Weaver; Pei-Yong Shi
Journal:  Nature       Date:  2020-10-26       Impact factor: 49.962

4.  Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.

Authors:  Timothy R Abbott; Girija Dhamdhere; Yanxia Liu; Xueqiu Lin; Laine Goudy; Leiping Zeng; Augustine Chemparathy; Stephen Chmura; Nicholas S Heaton; Robert Debs; Tara Pande; Drew Endy; Marie F La Russa; David B Lewis; Lei S Qi
Journal:  Cell       Date:  2020-04-29       Impact factor: 41.582

5.  TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds.

Authors:  Shiori Haga; Noriyo Nagata; Tadashi Okamura; Norio Yamamoto; Tetsutaro Sata; Naoki Yamamoto; Takehiko Sasazuki; Yukihito Ishizaka
Journal:  Antiviral Res       Date:  2009-12-06       Impact factor: 5.970

6.  Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies.

Authors:  Chunyan Yi; Xiaoyu Sun; Jing Ye; Zhiyang Ling; Longfei Ding; Meiqin Liu; Zhuo Yang; Xiao Lu; Yaguang Zhang; Liyang Ma; Wangpeng Gu; Aidong Qu; Jianqing Xu; Zhengli Shi; Bing Sun
Journal:  Cell Mol Immunol       Date:  2020-05-15       Impact factor: 11.530

7.  The mechanism of resistance to favipiravir in influenza.

Authors:  Daniel H Goldhill; Aartjan J W Te Velthuis; Robert A Fletcher; Pinky Langat; Maria Zambon; Angie Lackenby; Wendy S Barclay
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-23       Impact factor: 11.205

8.  Evasion of Type I Interferon by SARS-CoV-2.

Authors:  Hongjie Xia; Zengguo Cao; Xuping Xie; Xianwen Zhang; John Yun-Chung Chen; Hualei Wang; Vineet D Menachery; Ricardo Rajsbaum; Pei-Yong Shi
Journal:  Cell Rep       Date:  2020-09-19       Impact factor: 9.423
  8 in total
  75 in total

1.  How the coronavirus infects cells - and why Delta is so dangerous.

Authors:  Megan Scudellari
Journal:  Nature       Date:  2021-07       Impact factor: 49.962

2.  Homogeneous surrogate virus neutralization assay to rapidly assess neutralization activity of anti-SARS-CoV-2 antibodies.

Authors:  Sun Jin Kim; Zhong Yao; Morgan C Marsh; Debra M Eckert; Michael S Kay; Anna Lyakisheva; Maria Pasic; Aiyush Bansal; Chaim Birnboim; Prabhat Jha; Yannick Galipeau; Marc-André Langlois; Julio C Delgado; Marc G Elgort; Robert A Campbell; Elizabeth A Middleton; Igor Stagljar; Shawn C Owen
Journal:  Nat Commun       Date:  2022-07-01       Impact factor: 17.694

3.  C57BL/6J Mice Are Not Suitable for Modeling Severe SARS-CoV-2 Beta and Gamma Variant Infection.

Authors:  Joshua M Currey; Felix Rabito; Nicholas J Maness; Robert V Blair; Jay Rappaport; Xuebin Qin; Jay K Kolls; Akhilesh K Srivastava
Journal:  Viruses       Date:  2022-05-05       Impact factor: 5.818

4.  Correlation Analysis of Anti-SARS-CoV-2 RBD IgG and Neutralizing Antibody against SARS-CoV-2 Omicron Variants after Vaccination.

Authors:  Nuchjira Takheaw; Chalerm Liwsrisakun; Warawut Chaiwong; Witida Laopajon; Supansa Pata; Juthamas Inchai; Pilaiporn Duangjit; Chaicharn Pothirat; Chaiwat Bumroongkit; Athavudh Deesomchok; Theerakorn Theerakittikul; Atikun Limsukon; Pattraporn Tajarernmuang; Nutchanok Niyatiwatchanchai; Konlawij Trongtrakul; Watchara Kasinrerk
Journal:  Diagnostics (Basel)       Date:  2022-05-25

5.  Observational study of factors associated with morbidity and mortality from COVID-19 in Lebanon, 2020-2021.

Authors:  Moni Nader; Omar Zmerli; Daniel E Platt; Hamdan Hamdan; Salwa Hamdash; Rami Abi Tayeh; Jad Azar; Diana Kadi; Youssef Sultan; Taha Bazarbachi; Gilbert Karayakoupoglou; Pierre Zalloua; Eid Azar
Journal:  PLoS One       Date:  2022-10-19       Impact factor: 3.752

6.  A cross-sectional study of COVID-19 outbreak in Indian population.

Authors:  Murugesan Arumugam; Raleena Begum Haja Najimudeen; Arya Vijayan; Bhuvaneshwari Sathyamoorthy; Prashant S Patole
Journal:  Ann Med Surg (Lond)       Date:  2022-04-01

Review 7.  The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication.

Authors:  Qin Ning; Di Wu; Xiaojing Wang; Dong Xi; Tao Chen; Guang Chen; Hongwu Wang; Huiling Lu; Ming Wang; Lin Zhu; Junjian Hu; Tingting Liu; Ke Ma; Meifang Han; Xiaoping Luo
Journal:  Signal Transduct Target Ther       Date:  2022-02-23

8.  Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients.

Authors:  Zhenkui Hu; Xing Huang; Jianguo Zhang; Shixiang Fu; Daoyin Ding; Zhimin Tao
Journal:  Front Med (Lausanne)       Date:  2022-01-03

9.  The Pathogenetic Dilemma of Post-COVID-19 Mucormycosis in India.

Authors:  Sankha Shubhra Chakrabarti; Upinder Kaur; Sushil Kumar Aggarwal; Ahalya Kanakan; Adesh Saini; Bimal Kumar Agrawal; Kunlin Jin; Sasanka Chakrabarti
Journal:  Aging Dis       Date:  2022-02-01       Impact factor: 6.745

Review 10.  Review of Ribosome Interactions with SARS-CoV-2 and COVID-19 mRNA Vaccine.

Authors:  Jiao Wei; Aimin Hui
Journal:  Life (Basel)       Date:  2022-01-01
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