Risk Factors of Delayed Recovery of Gastrointestinal Function After Ileostomy Reversal for Rectal Cancer Patients.

PURPOSE: The aim of this study was to identify the risk factors associated with delayed recovery of gastrointestinal function after ileostomy reversal for rectal cancer patients.
METHODS: In this retrospective study, the data of rectal cancer patients who underwent ileostomy reversal from January 2018 to December 2019 at the Sixth Affiliated Hospital of Sun Yat-sen University were assessed to investigate potential risk factors of delayed flatus after ileostomy reversal.
RESULTS: A total of 282 patients were eligible for this study. Postoperative first flatus time ranged from 1 to 9 days, of which 58.8% patients presented with delayed flatus that was longer than 3 days. Univariate analysis showed that delayed postoperative flatus was significantly associated with the length of postoperative hospital stay (P<0.001) and postoperative complications (P=0.037). Multivariate analysis showed that intravenous fluid infusion at postoperative day 1 (POD1) (OR=1.001, 95% CI: 1.001-1.002, P=0.001) and duration of stoma ≥6 months (OR=2.005, 95% CI:1.155-3.657, P=0.014) were independent risk factors for delayed flatus.
CONCLUSION: Increased intravenous fluid infusion at POD1 and duration of stoma ≥6 months were related to delayed recovery of gastrointestinal function after ileostomy reversal for rectal cancer patients.

Introduction

Colorectal cancer is the third-most prevalent cancer and the second-leading cause of death worldwide, with 1.93 million new cases and 930,000 deaths in 2020,1 of which rectal cancer accounted for 44% of these cases.2,3 Surgical resection is the main treatment for rectal cancer and being a high-risk procedure, it is often accompanied by serious complications.4,5 Anastomotic leakage (AL) is a common but serious complication of rectal cancer and is associated with increased hospital stay, additional medical expenses, reduced survival, and unexpected early death of rectal cancer patients.4 To reduce the risk of AL, or at least to reduce complications of anastomotic dehiscence, a temporary defunctioning stoma is often required.6–8

However, temporary defunctioning stoma like temporary ileostomy requires a second surgery to restore intestinal continuity and may increase patients’ discomfort, length of hospital stay, and treatment costs. It is also associated with postoperative morbidities, such as postoperative intestinal obstruction, incision infection, AL, intestinal perforation and peritonitis, in up to 20% of the patients.9,10 Among these complications, delayed gastrointestinal function recovery (GIFR) could lead to accumulation of gas and effusion in the gastrointestinal tract lumen and increases the likelihood of intestinal obstruction and dysregulation of the gastrointestinal flora. The main clinical manifestations of delayed GIFR are delayed flatus or defecation, abdominal pain, abdominal distension, nausea, vomiting, and postoperative intestinal obstruction which often require nasogastric tube intubation.10–12 Delayed GIFR also affects the time for early oral nutrition, leading to insufficient nutritional supply and time for adjuvant treatment, thus, influencing treatment outcomes and patients’ survival.13

GIFR and tolerance to oral diet are among the important criteria for postoperative discharge for rectal cancer patients.14 GIFR has been shown to affect the time for ileostomy reversal as inadequate recovery can lead to an increase in hospital stay of up to 23 days.12 Further, it was reported that intravenous fluid infusion, early enteral nutrition, procedure type, choice of postoperative analgesia, and surgery-induced stress response, was related to GIFR after ileostomy reversal surgery.15–17 However, few studies have investigated the risk factors for delayed GIFR after ileostomy reversal.

In this study, we aimed to identify the risk factors associated with GIFR after ileostomy reversal of rectal cancer patients for early clinical intervention in advance after ileostomy reversal in high-risk patients.

Methods

Patients and Data Collection

The data of rectal cancer patients who underwent ileostomy reversal surgery from January 2018 to December 2019 at the Sixth Affiliated Hospital, Sun Yat-sen University (Guangzhou, P. R. China) were retrospectively retrieved.

The data retrieved included demographics and clinical data, such as age, gender, drinking history, smoking status, concomitant disease, tumor recurrence or metastasis, BMI, pTNM stages of the primary tumor, distance from the tumor to the anus, chemotherapy, radiotherapy, surgical approach of primary tumor resection, duration of stoma ≥6 months, operation duration of ileostomy reversal, methods of anastomosis, intravenous fluid infusion during ileostomy reversal surgery, intravenous fluid infusion in POD1, first postoperative flatus time, length of postoperative hospital stay, complications after primary procedure. The study exclusion criteria were patients with incomplete clinical data, the presence of synchronous/metachronous cancers, and those who underwent other major surgical interventions during the ileostomy reversal surgery.

Surgical Procedure and Group Classification

All the patients received ileostomy closure via ileostomy site incision with no laparotomy. Intravenous or oral analgesics were used for pain management after surgery without epidural analgesia. The general protocol for IV fluid administration was 1.5mL/kg/hr; however, the amount of IV fluid was also determined according to the patient’s oral intake and fluid loss. Postoperative flatus is a sign of GIFR, which was prospectively recorded in real-time in the hospital information system (HIS) by nurses at our department. In this study, delayed GIFR was defined as postoperative first flatus time ≥3 days after ileostomy reversal surgery.

Statistical Analysis

Data analysis was performed using the SPSS software (ver. 22.0; Chicago, IL, USA). Continuous data are expressed as the mean±standard deviation or median (IQR). Continuous variables and categorical variables were assessed using the t-tests or Mann–Whitney U. All considerable postoperative flatus-related factors were analyzed using univariate analysis; then, variables with P<0.1 were selected for the multivariate analysis using logistic regression. Receiver operating characteristic (ROC) curve analyses were conducted to predict the risk factors of delayed GIFR after ileostomy reversal surgery. A two-sided P<0.05 was considered statistically significant.

Results

From January 2018 to December 2019, a total of 342 patients were screened, and 282 patients were found eligible for this study (Figure 1). Postoperative first flatus time of all patients was 3 (range, 1–9) days, and the 75th percentile of all the postoperative first flatus time was 3 days. Based on the time to first flatus classification criteria, 119 and 163 patients were classified in the early and delayed flatus group, respectively. The rate of delayed flatus was 58.8%. The median length of postoperative hospital stay was 7 (range 3–23) days in the entire cohort. Compared with the early flatus group, the length of postoperative hospital stay was significantly longer in the delayed flatus group (7.1±2.8 days vs 8.3±2.8 days, P<0.001). Three (2.5%) patients in the early flatus group and 6 (3.7%) in the delayed flatus group had postoperative complications. Postoperative complications were significantly associated with delayed postoperative flatus function (P=0.037).

Figure 1

Flow chart of rectal cancer patient selection for this study.

Table 1 illustrates the comparisons of demographic and clinical data of patients in early and delayed flatus groups. Patients in the delayed flatus group had a longer operative duration of ileostomy reversal (P=0.022), more intravenous fluid infusion on postoperative day 1 (POD1) (P<0.001), and longer duration of stoma (≥6 months) (P=0.030) than that of early flatus groups. Multivariate analysis (Table 2) showed that intravenous fluid infusion in POD1 (OR=1.001, 95% CI: 1.001–1.002, P=0.001) and duration of stoma ≥6 months (OR=2.005, 95% CI:1.155–3.657, P=0.014) were independent risk factors for delayed flatus.

Table 1

Comparison of the Demographic and Clinical Characteristics

Variables	Early Flatus Group (n=119)	Delayed Flatus Group (n=163)	P
Age, median (IQR)	59 (49, 66)	61(53, 68)	0.053
Male, n (%)	82 (68.9)	106 (65.0)	0.495
Drinking history, n (%)	2 (1.7)	1 (0.6)	0.783
Smoking status, n (%)	4 (3.4)	7 (4.3)	0.930
Concomitant disease, n (%)	29 (24.4)	35 (21.5)	0.175
Tumor recurrence or metastasis, n (%)	6 (5.0)	7 (4.3)	0.767
BMI <18.5 kg/m2, n (%)	14 (11.8)	13 (8.0)	0.566
pTNM stages of the primary tumor, n (%)			0.946
0	12 (10.1)	17 (10.4)
I	33 (27.7)	48 (29.4)
II	43 (36.1)	50 (30.7)
III	25 (21.0)	40 (24.5)
IV	6 (5.0)	8 (4.9)
Distance from the primary tumor to the anus <5 cm, n (%)	65 (54.6)	72 (44.2)	0.083
Chemotherapy, n (%)	75 (63.0)	100 (61.3)	0.775
Radiotherapy, n (%)	16 (13.4)	25 (15.3)	0.656
Surgical approach of primary tumor resection, n (%)			0.102
Dixon	61 (51.3)	93 (57.1)
Parks	21 (17.6)	40 (24.5)
Bacon	4 (3.4)	4 (2.5)
TaTME	33 (27.7)	26 (20.0)
Duration of stoma ≥6 months, n (%)	32 (26.9)	64 (39.3)	0.030
Operative duration of ileostomy reversal, min, median (IQR)	82 (60,105.5)	95 (60,123)	0.022
Methods of anastomosis			0.326
Suture	24 (20.2)	41 (25.2)
Stapled	95 (79.8)	122 (74.8)
Intravenous fluid volume during ileostomy reversal surgery, mL, median (IQR)	1300 (1100, 1600)	1300 (1100, 1600)	0.179
Intravenous fluid infusion in POD1, mL, median (IQR)	2400 (1900, 2700)	2740 (2350, 3070)	0.000
Complications after primary procedure, n (%)	63 (52.9)	72 (44.2)	0.145

Abbreviations: POD1, postoperative day 1; IQR, interquartile range.

Table 2

Multivariate Logistic Regression Analysis

Variables	B	OR	95%CI Lower Limit–Higher Limit	P
Intravenous fluid infusion in POD1	0.001	1.001	1.001–1.002	0.001
Duration of stoma ≥6 months	0.720	2.005	1.155–3.657	0.014

Abbreviations: POD1, postoperative day 1; OR, odds ratio; CI, confidence interval.

ROC curve analysis was used to evaluate the potency of the prediction model in predicting the delayed flatus after ileostomy reversal surgery. As shown in Figure 2, the predictive power of the prediction model was significant, with an AUC of 0.704 (95% CI: 0.647–0.757, P<0.001). When the Hosmer-Lemeshow method was used, the value of X2 was 10.399 (P > 0.05), suggesting that the prediction model fitted well.

Figure 2

ROC curve of a new model for predicting the delayed flatus after ileostomy reversal in rectal cancer patients ROC AUC was 0.704 (95% CI: 0.647–0.757, P<0.001). When the Hosmer-Lemeshow method was used, the value of X2 was 10.399, P > 0.05.

Figure 3 illustrates the association of delayed flatus with duration of stoma and intravenous fluid infusion. The proportions of delayed flatus in patients with duration of stoma for <3 months, 3 to <6 months, 6 to <9 months, and ≥9 months were 54.1%, 52.3%, 64.3% and 73.1%, respectively. Similarly, the proportions of delayed flatus in patients receiving fluid infusion<1000 mL, 1000 to <2000 mL, 2000 to <3000 mL and ≥3000 mL were 33.3%, 34.0%, 56.1% and 82.0%, respectively. The proportions of delayed flatus almost increased as the duration of stoma or intravenous fluid infusion in POD1 increased.

Figure 3

Association of delayed flatus with duration of stoma (A) or fluid infusion (B) the proportions of delayed flatus almost increased as the duration of stoma or intravenous fluid infusion POD1 increased.

Discussion

In this study, we found that postoperative first flatus time ranged from 1 to 9 days and delayed flatus occurred in more than half of the patients (58.8%) who had stoma closure surgery, which significantly increased their length of postoperative hospital stay. The median length of postoperative hospital stay after ileostomy reversal was 7 (range, 3 to 23) days and was similar to previous literature.12,18

Ileostomy closure not only increases the patient’s treatment cost, physical and mental burden but is also associated with high morbidity. In this study, the rate of postoperative complications was only 0.3%. During the procedure of ileostomy reversal, most patients received gunsight sutures and stapler anastomosis, which could have decreased surgical-site infection and intestinal obstruction, thereby leading to a reduction in postoperative complications in this study.19,20 Delayed flatus may lead to increased morbidities, such as intestinal paralysis, intestinal obstruction, and more. In this present study, delayed GFIR was significantly associated with postoperative complications (P=0.037). Compared with delayed GFIR group, patients in the early flatus group tended to have a reduced risk of postoperative complications, as compared to the delayed flatus group (3.7% vs 2.5%, P=0.838).

Although intestinal continuity was restored after the ileostomy reversal surgery, postoperative GIFR of some patients was slow, which is a problem that cannot be ignored. Risk factors for the postoperative GIFG remain unclear. Interestingly, in this study, we found that intravenous fluid infusion on POD1 was an independent risk factor for the delayed flatus in the patients after ileostomy reversal surgery. All the patients received fluid infusion in POD1 according to the balance of oral intake and fluid loss. Some patients had received larger amount of fluid due to their low urine output or hypotension and the amount of fluid infusion in POD1 was variable in this study. The increased fluid infusion in POD1 resulted in prolonged flatus. Fluid management plays a very important role in improving patients’ outcomes during the perioperative period. Patients receiving large volume of fluid infusion could experience fluid overload and be at increased risk of cardiac preload and postoperative complications, such as AL, pulmonary edema, pneumonia, and wound infection.15,21 Nisanevich et al showed that restrictive fluid infusion could lead to earlier time to flatus and bowel movement, fewer immediate complications, and length of hospital stay.22 Early oral intake in the postoperative period to reduce the intravenous fluid infusion should be encouraged. Early enteral nutrition as reported can facilitate the improvement of nutritional status, further enhancement of GIFR, reduce the risk of complications and shorten postoperative hospital stay.23–26

The duration from the primary operation to the restoration of gastrointestinal tract continuity may vary considerably as it depends on the tumor status, pelvic floor function and the patient’s condition.27 The present study showed that the average time between the primary operation and the closure of the ileostomy was 171 days, which was similar to a study by Law et al (183 days).28 Furthermore, in this study, we found that the duration of stoma ≥6 months was another independent risk factor for delayed flatus. Previously, it was reported that diverting stoma was associated with bowel dysfunction, which may be due to alterations in colonic nutrition leading to inflammation, changes in the bacterial flora, and/or atrophy of motility or sensory elements.29–31 The rate of diversion colitis is reported to be 70% to 100% in Western countries who underwent diversion ostomy.32 Recent studies reported that the long duration of stoma ≥6 months was associated with a 3.7-fold increase in the risk of major bowel dysfunction after the restoration of bowel continuity.33,34 Therefore, this could explain the association of longer duration of stoma to cause prolonged GIFR found in this study. And it was reported that early closure is a safe and effective therapeutic approach, improving the recovery.35 In addition, the operative duration of ileostomy reversal in the delayed flatus group was significantly longer than in the early flatus group, which was consistent with a previous report which showed that the first flatus was detected earlier in the shorter operative duration group.36 However, the operative duration of ileostomy reversal was not an independent risk factor for delayed flatus in this study.

The main limitations of this study were its retrospective design, single-center data and sample size, which could have led to a certain level of inevitable bias. A prospective, multi-center study with larger sample size should be conducted to confirm our findings to better guide the treatment and improve the recovery of these patients.

Conclusion

In this study, we observed that the incidence of delayed flatus was 58.8%, and increased intravenous fluid infusion at POD1 and duration of stoma ≥6 months were independently associated with delayed flatus for patients undergoing ileostomy reversal surgery. Larger size cohort and prospective settings are needed to confirm whether a reduction in intravenous fluid infusion on POD1 and shorter duration of stoma could improve treatment outcomes of rectal cancer patients.