Literature DB >> 3423241

[Radioprotective efficacy of acyl hydrazones].

O V Arapov, O F Alferova, E I Levocheskaia, I I Krasil'nikov.   

Abstract

As was shown in experiments with rats and mice some acyl hydrazones have a pronounced radioprotective effect. The protective efficiency makes 40-55 per cent with the preparation doses of 1-10 mg/kg. The toxicity of hydrazones is 2 g/kg which is lower, than that of the known sulfur-containing agents and substituted indolylalkylamines. The radio-protective efficiency of the drug depends on its complex-forming ability.

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Year:  1987        PMID: 3423241

Source DB:  PubMed          Journal:  Radiobiologiia        ISSN: 0033-8192


  4 in total

1.  (E)-3-Hydr-oxy-N'-(2-hydroxy-benzyl-idene)-2-naphthohydrazide.

Authors:  Hassan Hosseini Monfared; Rahman Bikas; Peter Mayer
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-24

2.  (2Z,N'E)-N'-[(2-Hy-droxy-1-naphth-yl)methyl-idene]furan-2-carbohydrazonic acid.

Authors:  Rahman Bikas; Hassan Hosseini Monfared; Keyvan Bijanzad; Ahmet Koroglu; Canan Kazak
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-07-21

3.  (E)-N'-(2-Hy-droxy-benzyl-idene)furan-2-carbohydrazide.

Authors:  Rahman Bikas; Hassan Hosseini Monfared; Canan Kazak; N Burcu Arslan; Keyvan Bijanzad
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-07-14

4.  (E)-2-(2-Hy-droxy-5-iodo-benzyl-idene)hydrazinecarboxamide.

Authors:  Rahman Bikas; Samra Nikbakht Sardari; Seyed Sajjad Hosseini; Gholam Hossein Shahverdizadeh; Behrouz Notash
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-03-17
  4 in total

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