Literature DB >> 3422222

1,25-Dihydroxyvitamin D3 transcriptionally regulates tumour necrosis factor mRNA during HL-60 cell differentiation.

M Steffen1, Y Cayre, K R Manogue, M A Moore.   

Abstract

We investigated TNF-alpha gene expression in HL-60 cells under the influence of 1,25(OH)2D3. Our results show that TNF-alpha gene expression is transcriptionally activated by 1,25(OH)2D3. Despite the increase of TNF-alpha mRNA, very little TNF protein is found in either supernatants or cell lysates of HL-60 cells cultured in the presence of the vitamin. Therefore 1,25(OH)2D3 is regulating the transcription of the TNF-alpha gene in HL-60 cells without affecting translation. Our data suggest that an additional signal is necessary under physiological conditions to control post-transcriptionally TNF-alpha protein synthesis and secretion.

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Year:  1988        PMID： 3422222      PMCID： PMC1454706     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  19 in total

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3.  Macrophage-lymphocyte synergy in the production of osteoclast activating factor.

Authors:  J E Horton; J J Oppenheim; S E Mergenhagen; L G Raisz
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4.  Induction of differentiation in human promyelocytic leukemia cells by tumor promoters.

Authors:  G Rovera; T G O'Brien; L Diamond
Journal:  Science       Date:  1979-05-25       Impact factor: 47.728

5.  Absence of significant H-2 and beta 2-microglobulin mRNA expression by mouse embryonal carcinoma cells.

Authors:  D Morello; F Daniel; P Baldacci; Y Cayre; G Gachelin; P Kourilsky
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6.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

7.  The primary transcription unit of the mouse beta-major globin gene.

Authors:  E Hofer; J E Darnell
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

8.  Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3.

Authors:  Z Bar-Shavit; S L Teitelbaum; P Reitsma; A Hall; L E Pegg; J Trial; A J Kahn
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

9.  Enhanced release of lymphotoxins by interferon-treated cells.

Authors:  D Wallach; T Hahn
Journal:  Cell Immunol       Date:  1983-03       Impact factor: 4.868

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  4 in total

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Authors:  G Saggese; G Federico; M Balestri; A Toniolo
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4.  Regulation of interleukin-1 and tumour necrosis factor gene expression in myelomonocytic cell lines by 1,25-dihydroxyvitamin D3.

Authors:  A K Bhalla; T Paavonen; M M Williams; P J Delves; P M Lydyard
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  4 in total

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