Literature DB >> 286421

Induction of differentiation in human promyelocytic leukemia cells by tumor promoters.

G Rovera, T G O'Brien, L Diamond.   

Abstract

Phorbol diester tumor promoters and the promoter mezerein convert human promyelocytic leukemia cells in culture into adherent, nonproliferating cells with many of the characteristics of macrophages. Other types of promoters such as anthralin, phenobarbital, and saccharin do not have this effect. Various compounds that can inhibit some of the biological and biochemical effects of tumor promoters do not interfere with the induction of cell adherence and differentiation by the effective promoters.

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Year:  1979        PMID： 286421     DOI： 10.1126/science.286421

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  86 in total

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9.  Possible mechanism of phorbol diester-induced maturation of human promyelocytic leukemia cells.

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10.  Phorbol ester-induced expression, phosphorylation, and translocation of protein-tyrosine-phosphatase 1C in HL-60 cells.

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Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205
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