Ira Remsen, Osler, the Flexner Report, and the full-time plan.

A famous letter from Sir William Osler to Ira Remsen, dated September 1, 1911, concerns Osler's objections to the full-time plan, whereby clinical professors should focus on research and abstain from private practice. Previous accounts of this well-known episode make little or no mention of the recipient other than his being president of the Johns Hopkins University. Remsen, in retrospect, was uniquely positioned to champion ideas advanced by Abraham Flexner, the General Education Board of the Rockefeller Foundation, and some of Osler's former colleagues at Johns Hopkins, notably William H. Welch. Remsen had previously expressed the need for Hopkins to advance science-based medicine; he had introduced Abraham Flexner to the Carnegie Foundation (which led to the Flexner Report); and he appears to have been the first US-born person to possess both a medical degree and a doctorate in basic science. Caught in the middle of a faculty controversy, Remsen chose not to pursue the matter further for reasons that included a passive administrative style, concerns about his health, and friendship with Osler.