| Literature DB >> 34201950 |
Niamh O'Kennedy1, Ruedi Duss2, Asim K Duttaroy3.
Abstract
Our understanding of platelet functionality has undergone a sea change in the last decade. No longer are platelets viewed simply as regulators of haemostasis; they are now acknowledged to be pivotal in coordinating the inflammatory and immune responses. This expanded role for platelets brings new opportunities for controlling a range of health conditions, targeting platelet activation and their interactions with other vascular cells. Antiplatelet drugs may be of wider utility than ever expected but often cause platelet suppression too strong to be used out of clinical settings. Dietary antiplatelets represent a nutritional approach that can be efficacious while safe for general use. In this review, we discuss potential new uses for dietary antiplatelets outside the field of cardiovascular health, with specific reference to the water-soluble tomato extract Fruitflow®. Its uses in different aspects of inflammation and immune function are discussed, highlighting exercise-induced inflammation, mediating the effects of air pollution, and controlling thrombotic aspects of the immune response. Potential future developments in women's health, erectile dysfunction, and the allergic response indicate how broad the utility of dietary antiplatelets can be.Entities:
Keywords: dietary antiplatelet; immunothrombosis; inflammation; particulate air pollution; platelet activation; platelet function; platelet hyperactivity; platelet-leukocyte aggregates; water-soluble tomato extract
Year: 2021 PMID: 34201950 DOI: 10.3390/nu13072184
Source DB: PubMed Journal: Nutrients ISSN: 2072-6643 Impact factor: 5.717