| Literature DB >> 14641962 |
J Yamamoto1, T Taka, K Yamada, Y Ijiri, M Murakami, Y Hirata, A Naemura, M Hashimoto, T Yamashita, K Oiwa, J Seki, H Suganuma, T Inakuma, T Yoshida.
Abstract
The prevention of arterial thrombotic diseases has a high priority in developed countries. An inappropriate diet may be an important risk factor for thrombotic events. The daily intake of an anti-thrombotic diet may offer a convenient and effective way of prevention. The aim of the present study was to test tomato extracts for anti-thrombotic effects and to identify those varieties that have such an effect. A shear-induced platelet-function test (haemostatometry) was used to test anti-thrombotic potential in vitro. Extracts from those tomato varieties that showed a significant anti-thrombotic activity in vitro were further assessed in vivo, using a laser-induced thrombosis test in mice. One tomato variety (KG99-4) showed significant anti-thrombotic activity both in vitro and in vivo. KG99-4 inhibited not only platelet-rich thrombus formation but also had a thrombolytic effect. It is concluded that haemostatometry can detect and classify the anti-thrombotic potential of fruits and vegetables and offers a simple way of screening for such effects.Entities:
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Year: 2003 PMID： 14641962 DOI： 10.1079/bjn2003994
Source DB: PubMed Journal: Br J Nutr ISSN： 0007-1145 Impact factor: 3.718