Literature DB >> 34201844

The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives.

Vasileia Ismini Alexaki1.   

Abstract

Increased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central players in it. The present review discusses the effects of obesity, chronic peripheral inflammation and obesity-associated metabolic and endocrine perturbations, including insulin resistance, dyslipidemia and increased glucocorticoid levels, on microglial function.

Entities:  

Keywords:  adiponectin; cytokines; dyslipidemia; glucocorticoids; gut microbiome; insulin resistance; leptin; microglia; neurodegeneration; neuroinflammation; obesity; systemic inflammation

Year:  2021        PMID： 34201844     DOI： 10.3390/cells10071584

Source DB:  PubMed          Journal:  Cells        ISSN： 2073-4409            Impact factor:   6.600


  428 in total

Review 1.  Inflammatory mechanisms linking obesity and metabolic disease.

Authors:  Alan R Saltiel; Jerrold M Olefsky
Journal:  J Clin Invest       Date:  2017-01-03       Impact factor: 14.808

2.  Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures.

Authors:  Christopher J Bohlen; F Chris Bennett; Andrew F Tucker; Hannah Y Collins; Sara B Mulinyawe; Ben A Barres
Journal:  Neuron       Date:  2017-05-17       Impact factor: 17.173

3.  Dietary saturated fat and monounsaturated fat have reversible effects on brain function and the secretion of pro-inflammatory cytokines in young women.

Authors:  Julie A Dumas; Janice Y Bunn; Joshua Nickerson; Karen I Crain; David B Ebenstein; Emily K Tarleton; Jenna Makarewicz; Matthew E Poynter; Craig Lawrence Kien
Journal:  Metabolism       Date:  2016-08-09       Impact factor: 8.694

4.  A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers.

Authors:  Charles L Raison; Robin E Rutherford; Bobbi J Woolwine; Chen Shuo; Pamela Schettler; Daniel F Drake; Ebrahim Haroon; Andrew H Miller
Journal:  JAMA Psychiatry       Date:  2013-01       Impact factor: 21.596

5.  Gut microbiota from twins discordant for obesity modulate metabolism in mice.

Authors:  Vanessa K Ridaura; Jeremiah J Faith; Federico E Rey; Jiye Cheng; Alexis E Duncan; Andrew L Kau; Nicholas W Griffin; Vincent Lombard; Bernard Henrissat; James R Bain; Michael J Muehlbauer; Olga Ilkayeva; Clay F Semenkovich; Katsuhiko Funai; David K Hayashi; Barbara J Lyle; Margaret C Martini; Luke K Ursell; Jose C Clemente; William Van Treuren; William A Walters; Rob Knight; Christopher B Newgard; Andrew C Heath; Jeffrey I Gordon
Journal:  Science       Date:  2013-09-06       Impact factor: 47.728

6.  Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.

Authors:  Iakovos Lazaridis; Ioannis Charalampopoulos; Vassilia-Ismini Alexaki; Nicolaos Avlonitis; Iosif Pediaditakis; Paschalis Efstathopoulos; Theodora Calogeropoulou; Elias Castanas; Achille Gravanis
Journal:  PLoS Biol       Date:  2011-04-26       Impact factor: 8.029

7.  A new genetic strategy for targeting microglia in development and disease.

Authors:  Gabriel L McKinsey; Carlos O Lizama; Amber E Keown-Lang; Abraham Niu; Nicolas Santander; Amara Larpthaveesarp; Elin Chee; Fernando F Gonzalez; Thomas D Arnold
Journal:  Elife       Date:  2020-06-23       Impact factor: 8.140

8.  Perturbation of the Monocyte Compartment in Human Obesity.

Authors:  Kathleen Friedrich; Miriam Sommer; Sarah Strobel; Stephan Thrum; Matthias Blüher; Ulf Wagner; Manuela Rossol
Journal:  Front Immunol       Date:  2019-08-08       Impact factor: 7.561

9.  Widespread reductions of white matter integrity in patients with long-term remission of Cushing's disease.

Authors:  Steven J A van der Werff; Cornelie D Andela; J Nienke Pannekoek; Onno C Meijer; Mark A van Buchem; Serge A R B Rombouts; Roos C van der Mast; Nienke R Biermasz; Alberto M Pereira; Nic J A van der Wee
Journal:  Neuroimage Clin       Date:  2014-02-10       Impact factor: 4.881

10.  Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10).

Authors:  Starlee Lively; Lyanne C Schlichter
Journal:  Front Cell Neurosci       Date:  2018-07-24       Impact factor: 5.505
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  8 in total

Review 1.  Leptin Signaling in Obesity and Colorectal Cancer.

Authors:  Claudia Terezia Socol; Alexandra Chira; Maria Antonia Martinez-Sanchez; Maria Angeles Nuñez-Sanchez; Cristina Maria Maerescu; Daniel Mierlita; Alexandru Vasile Rusu; Antonio Jose Ruiz-Alcaraz; Monica Trif; Bruno Ramos-Molina
Journal:  Int J Mol Sci       Date:  2022-04-24       Impact factor: 6.208

Review 2.  Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder.

Authors:  Reza Rahimian; Claudia Belliveau; Rebecca Chen; Naguib Mechawar
Journal:  Front Psychiatry       Date:  2022-06-16       Impact factor: 5.435

3.  Transcriptome of visceral adipose tissue identifies an inflammation-related ceRNA network that regulates obesity.

Authors:  Ganbin Li; Haoyu Zhang; Ke Cao; Zhiwei Zhai; Zhenjun Wang; Lei Yang; Jiagang Han
Journal:  Mol Cell Biochem       Date:  2022-01-22       Impact factor: 3.396

Review 4.  Aberrant Feeding and Growth in Neonates With Prenatal Opioid Exposure: Evidence of Neuromodulation and Behavioral Changes.

Authors:  Elizabeth Yen; Jill L Maron
Journal:  Front Pediatr       Date:  2022-01-21       Impact factor: 3.418

Review 5.  Obesity-Related Neuroinflammation: Magnetic Resonance and Microscopy Imaging of the Brain.

Authors:  Anita Woo; Amy Botta; Sammy S W Shi; Tomas Paus; Zdenka Pausova
Journal:  Int J Mol Sci       Date:  2022-08-08       Impact factor: 6.208

6.  Does Childhood Obesity Trigger Neuroinflammation?

Authors:  Valeria Domenica Zingale; Simone D'Angiolini; Luigi Chiricosta; Valeria Calcaterra; Giorgio Giuseppe Orlando Selvaggio; Gianvincenzo Zuccotti; Francesca Destro; Gloria Pelizzo; Emanuela Mazzon
Journal:  Biomedicines       Date:  2022-08-11

7.  Zinc Supplementation Partially Decreases the Harmful Effects of a Cafeteria Diet in Rats but Does Not Prevent Intestinal Dysbiosis.

Authors:  Samia Squizani; Jeferson Jantsch; Fernanda da Silva Rodrigues; Matheus Filipe Braga; Sarah Eller; Tiago Franco de Oliveira; Alexandre Kleber Silveira; José Cláudio Fonseca Moreira; Marcia Giovenardi; Marilene Porawski; Renata Padilha Guedes
Journal:  Nutrients       Date:  2022-09-22       Impact factor: 6.706

8.  ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses.

Authors:  Canelif Yilmaz; Thanasis Rogdakis; Alessia Latorrata; Evangelia Thanou; Eleftheria Karadima; Eleni Papadimitriou; Eleni Siapi; Ka Wan Li; Theodora Katsila; Theodora Calogeropoulou; Ioannis Charalampopoulos; Vasileia Ismini Alexaki
Journal:  Biomolecules       Date:  2022-03-09
  8 in total

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