Literature DB >> 341851

Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene.

P Bentley, F Oesch, H Glatt.   

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Year:  1977        PMID： 341851     DOI： 10.1007/bf00343276

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


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  16 in total

1.  Purification of rat liver epoxide hydratase to apparent homogeneity.

Authors:  P Bentley; F Oesch
Journal:  FEBS Lett       Date:  1975-11-15       Impact factor: 4.124

2.  High-pressure liquid chromatographic analysis of benzo(alpha)pyrene metabolism and covalent binding and the mechanism of action of 7,8-benzoflavone and 1,2-epoxy-3,3,3-trichloropropane.

Authors:  J K Selkirk; R G Croy; P P Roller; H V Gelboin
Journal:  Cancer Res       Date:  1974-12       Impact factor: 12.701

3.  Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide.

Authors:  P Sims; P L Grover; A Swaisland; K Pal; A Hewer
Journal:  Nature       Date:  1974-11-22       Impact factor: 49.962

4.  Epoxides metabolically produced from some known carcinogens and from some clinically used drugs. I. Differences in mutagenicity.

Authors:  H R Glatt; F Oesch; A Frigerio; S Garattini
Journal:  Int J Cancer       Date:  1975-11-15       Impact factor: 7.396

5.  Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols.

Authors:  A W Wood; R L Goode; R L Chang; W Levin; A H Conney; H Yagi; P M Dansette; D M Jerina
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

6.  Prevention of benzo(a)pyrene-induced mutagenicity by homogeneous epoxide hydratase.

Authors:  F Oesch; P Bentley; H R Glatt
Journal:  Int J Cancer       Date:  1976-10-15       Impact factor: 7.396

7.  Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

Authors:  A W Wood; W Levin; A Y Lu; H Yagi; O Hernandez; D M Jerina; A H Conney
Journal:  J Biol Chem       Date:  1976-08-25       Impact factor: 5.157

8.  Effects of inducers and epoxide hydrase on the metabolism of benzo(a)pyrene by liver microsomes and a reconstituted system: analysis by high pressure liquid chromatography.

Authors:  G Holder; H Yagi; P Dansette; D M Jerina; W Levin; A Y Lu; A H Conney
Journal:  Proc Natl Acad Sci U S A       Date:  1974-11       Impact factor: 11.205

9.  Epoxides derived from various polycyclic hydrocarbons as substrates of homogeneous and microsome-bound epoxide hydratase. A general assay and kinetic properties.

Authors:  P Bentley; H Schmassmann; P Sims; F Oesch
Journal:  Eur J Biochem       Date:  1976-10-01

10.  Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

Authors:  E Huberman; L Sachs; S K Yang; V Gelboin
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205
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  10 in total

Review 1.  Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:  F Oesch; E Fabian; Robert Landsiedel
Journal:  Arch Toxicol       Date:  2018-06-18       Impact factor: 5.153

2.  Cloning and molecular characterization of a soluble epoxide hydrolase from Aspergillus niger that is related to mammalian microsomal epoxide hydrolase.

Authors:  M Arand; H Hemmer; H Dürk; J Baratti; A Archelas; R Furstoss; F Oesch
Journal:  Biochem J       Date:  1999-11-15       Impact factor: 3.857

3.  Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites.

Authors:  F Oesch; D Raphael; H Schwind; H R Glatt
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

4.  Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization.

Authors:  H Glatt; F Oesch
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

5.  Induction of nuclear styrene monooxygenase and epoxide hydrolase in rat liver.

Authors:  E Garattini; G Gazzotti; M Salmona
Journal:  Experientia       Date:  1981-03-15

Review 6.  Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Authors:  F Oesch; E Fabian; K Guth; R Landsiedel
Journal:  Arch Toxicol       Date:  2014-11-05       Impact factor: 5.153

7.  Immuno-electron-microscopic studies on the subcellular distribution of rat liver epoxide hydrolase and the effect of phenobarbitone and 2-acetamidofluorene treatment.

Authors:  F Waechter; P Bentley; M Germann; F Oesch; W Stäubli
Journal:  Biochem J       Date:  1982-03-15       Impact factor: 3.857

Review 8.  Significance of various enzymes in the control of reactive metabolites.

Authors:  F Oesch
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

9.  Mutagenicity of quindoxin, its metabolites, and two substituted quinoxaline-di-N-oxides.

Authors:  L Beutin; E Preller; B Kowalski
Journal:  Antimicrob Agents Chemother       Date:  1981-09       Impact factor: 5.191

10.  Mechanism-based predictions of interactions.

Authors:  F Oesch; B Oesch-Bartlomowicz; J Arens; F Fähndrich; E Vogel; T Friedberg; H Glatt
Journal:  Environ Health Perspect       Date:  1994-11       Impact factor: 9.031
  10 in total

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