Literature DB >> 34166648

Rates of pregnancy among levonorgestrel and copper intrauterine emergency contraception initiators: Implications for backup contraception recommendations.

Kathryn E Fay1, Amelia C Clement2, Alexandra Gero2, Jennifer E Kaiser2, Jessica N Sanders2, Abena A BakenRa3, David K Turok2.   

Abstract

OBJECTIVE: This study assessed the timing, frequency, use of backup method and 1-month pregnancy rates among individuals who had an intrauterine device (IUD) placed as emergency contraception and reported intercourse within 7 days post-placement. STUDY
DESIGN: In this secondary analysis of a randomized control trial of IUDs for emergency contraception, 518 individuals reporting unprotected intercourse in the preceding 5 days had a 52 mg levonorgestrel intrauterine system (IUS) or 380 mm2 copper IUD placed outside the first week of their menstrual cycle. All participants were advised to use backup contraception for 7 days. We assessed pregnancy status 1 month after placement by urine testing or, when not available, by survey responses and electronic health record review.  Participants reported whether their first sexual activity after device placement occurred within 7 days of their placement, the frequency of intercourse and whether they used backup contraception.
RESULTS: Rapid return to sexual activity was common and use of backup contraception was rare, regardless of type of IUD placed. Of participants who resumed penile-vaginal intercourse in the first month, most (286/446, 64.1%) participants reported intercourse within 7 days of IUD placement; only 16.4% (74/446) used condoms or withdrawal. No pregnancies occurred among users of the levonorgestrel IUS who reported intercourse within 7 days of placement (0/138, 0.0%, 95% CI 0.0%, 2.6%) nor among users of the 380mm2 copper IUD (0/148, 0.0%, 95% CI 0.0%, 2.5%).
CONCLUSION: Pregnancy rates are low after placement of an IUD for emergency contraception, even among the many who resume intercourse within days following IUD placement without use of backup contraception. IMPLICATIONS: Clinical guidelines should facilitate access to contraception, including elimination of unnecessary recommendations for backup contraception or abstinence in the 7 days following 52 mg levonorgestrel intrauterine system.
Copyright © 2021. Published by Elsevier Inc.

Entities:  

Keywords:  Backup contraception; Intrauterine device; Practice guidelines

Mesh:

Substances:

Year:  2021        PMID: 34166648      PMCID: PMC9112236          DOI: 10.1016/j.contraception.2021.06.011

Source DB:  PubMed          Journal:  Contraception        ISSN: 0010-7824            Impact factor:   3.051


  21 in total

Review 1.  Progestin-only oral contraception: a comprehensive review.

Authors:  M F McCann; L S Potter
Journal:  Contraception       Date:  1994-12       Impact factor: 3.375

2.  Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.

Authors:  Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde
Journal:  J Biomed Inform       Date:  2008-09-30       Impact factor: 6.317

Review 3.  Immediate start of hormonal contraceptives for contraception.

Authors:  Laureen M Lopez; Sara J Newmann; David A Grimes; Kavita Nanda; Kenneth F Schulz
Journal:  Cochrane Database Syst Rev       Date:  2012-12-12

4.  Quick start: novel oral contraceptive initiation method.

Authors:  Carolyn Westhoff; Jennifer Kerns; Chelsea Morroni; Linda F Cushman; Lorraine Tiezzi; Patricia Aikins Murphy
Journal:  Contraception       Date:  2002-09       Impact factor: 3.375

5.  Predicting risk of ovulation in new start oral contraceptive users.

Authors:  Jill L Schwartz; Mitchell D Creinin; Helen C Pymar; Lynn Reid
Journal:  Obstet Gynecol       Date:  2002-02       Impact factor: 7.661

6.  Benchmark pregnancy rates and the assessment of post-coital contraceptives: an update.

Authors:  Daniel Li; Allen J Wilcox; David B Dunson
Journal:  Contraception       Date:  2015-01-12       Impact factor: 3.375

7.  Levonorgestrel vs. Copper Intrauterine Devices for Emergency Contraception.

Authors:  David K Turok; Alexandra Gero; Rebecca G Simmons; Jennifer E Kaiser; Gregory J Stoddard; Corinne D Sexsmith; Lori M Gawron; Jessica N Sanders
Journal:  N Engl J Med       Date:  2021-01-28       Impact factor: 91.245

8.  U.S. Selected Practice Recommendations for Contraceptive Use, 2016.

Authors:  Kathryn M Curtis; Tara C Jatlaoui; Naomi K Tepper; Lauren B Zapata; Leah G Horton; Denise J Jamieson; Maura K Whiteman
Journal:  MMWR Recomm Rep       Date:  2016-07-29

Review 9.  The efficacy of intrauterine devices for emergency contraception: a systematic review of 35 years of experience.

Authors:  Kelly Cleland; Haoping Zhu; Norman Goldstuck; Linan Cheng; James Trussell
Journal:  Hum Reprod       Date:  2012-05-08       Impact factor: 6.918

10.  Initiation of oral contraceptives using a quick start compared with a conventional start: a randomized controlled trial.

Authors:  Carolyn Westhoff; Stephen Heartwell; Sharon Edwards; Mimi Zieman; Linda Cushman; Christina Robilotto; Gretchen Stuart; Chelsea Morroni; Debra Kalmuss
Journal:  Obstet Gynecol       Date:  2007-06       Impact factor: 7.661

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