| Literature DB >> 34163056 |
Jingjing Xu1, Lauren E Jarocha2, Tilo Zollitsch2, Marcin Konowalczyk3, Kevin B Henbest2,3, Sabine Richert4, Matthew J Golesworthy3, Jessica Schmidt1, Victoire Déjean3, Daniel J C Sowood2, Marco Bassetto1,2, Jiate Luo2, Jessica R Walton2, Jessica Fleming2, Yujing Wei2, Tommy L Pitcher3, Gabriel Moise3, Maike Herrmann1, Hang Yin5, Haijia Wu6, Rabea Bartölke1, Stefanie J Käsehagen1, Simon Horst1, Glen Dautaj1, Patrick D F Murton2, Angela S Gehrckens2, Yogarany Chelliah7,8, Joseph S Takahashi7,8, Karl-Wilhelm Koch6,9, Stefan Weber4, Ilia A Solov'yov10,11, Can Xie12,13, Stuart R Mackenzie14, Christiane R Timmel15,16, Henrik Mouritsen17,18, P J Hore19.
Abstract
Night-migratory songbirds are remarkably proficient navigators1. Flying alone and often over great distances, they use various directional cues including, crucially, a light-dependent magnetic compass2,3. The mechanism of this compass has been suggested to rely on the quantum spin dynamics of photoinduced radical pairs in cryptochrome flavoproteins located in the retinas of the birds4-7. Here we show that the photochemistry of cryptochrome 4 (CRY4) from the night-migratory European robin (Erithacus rubecula) is magnetically sensitive in vitro, and more so than CRY4 from two non-migratory bird species, chicken (Gallus gallus) and pigeon (Columba livia). Site-specific mutations of ErCRY4 reveal the roles of four successive flavin-tryptophan radical pairs in generating magnetic field effects and in stabilizing potential signalling states in a way that could enable sensing and signalling functions to be independently optimized in night-migratory birds.Entities:
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Year: 2021 PMID： 34163056 DOI： 10.1038/s41586-021-03618-9
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962