Xingxiu Yang1, Xiaohui Jia1, Hua Ren1, Hongxing Zhang2. 1. Department of Neurology, Nanchong Central Hospital Nanchong, Sichuan Province, China. 2. Department of Neurology, Xi'an Gaoxin Hospital, Affiliated to Northwest University Xi'an, Shaanxi Province, China.
Abstract
OBJECTIVE: We aimed to investigate the short- and long-term efficacies of endovascular interventional therapy in acute ischemic stroke (AIS) patients. METHODS: In this retrospective study, 94 patients with AIS were recruited and divided into a control group (n=51) that was administered intra-arterial thrombolysis and an observation group (n=43) that was administered Solitaire stent thrombectomies. The postoperative recanalization and overall response rates were recorded in both groups. The hemodynamic parameters (high shear viscosity, low shear viscosity, plasma viscosity, and hematocrit), and the C-reactive protein, interleukin 6, and fibrinogen levels were compared between the two groups before and after the treatment. In addition, the National Institutes of Health Stroke Scale and the modified Rankin Scale scores were analyzed before the treatment and at 1 and 3 months after the treatment in both groups. After a 3-year follow-up, a survival analysis was also performed using the Kaplan-Meier survival method. RESULTS: The overall response and recanalization rates were higher in the observation group than they were in the control group (P<0.05). Before the treatment, there were no significant differences in the hemodynamic parameter, C-reactive protein, interleukin, 6 and fibrinogen levels in the two groups (P>0.05). After the treatment, the above levels in both groups decreased compared to their levels before the treatment, and the observation group had significantly lower levels than the control group (P<0.05). Moreover, no significant differences were seen in National Institutes of Health Stroke Scale and modified Rankin Scale scores between the two groups before the treatment (P>0.05). After the treatment, the above scores were decreased in both groups at 1 and 3 months compared to their pre-treatment levels, and the scores were significantly lower in the observation group than they were in the control group at 1 month after the treatment (P<0.05). After a 3-year follow-up, the Kaplan-Meier survival curves demonstrated that the survival times were significantly longer in the observation group than they were in the control group (P<0.05). CONCLUSION: Solitaire stent thrombectomy markedly ameliorates neurological deficits in AIS patients, improves their recanalization rated, regulates the inflammatory response and hemodynamics in the lesion areas, thus exerting favorable short- and long-term clinical effects. AJTR
OBJECTIVE: We aimed to investigate the short- and long-term efficacies of endovascular interventional therapy in acute ischemic stroke (AIS) patients. METHODS: In this retrospective study, 94 patients with AIS were recruited and divided into a control group (n=51) that was administered intra-arterial thrombolysis and an observation group (n=43) that was administered Solitaire stent thrombectomies. The postoperative recanalization and overall response rates were recorded in both groups. The hemodynamic parameters (high shear viscosity, low shear viscosity, plasma viscosity, and hematocrit), and the C-reactive protein, interleukin 6, and fibrinogen levels were compared between the two groups before and after the treatment. In addition, the National Institutes of Health Stroke Scale and the modified Rankin Scale scores were analyzed before the treatment and at 1 and 3 months after the treatment in both groups. After a 3-year follow-up, a survival analysis was also performed using the Kaplan-Meier survival method. RESULTS: The overall response and recanalization rates were higher in the observation group than they were in the control group (P<0.05). Before the treatment, there were no significant differences in the hemodynamic parameter, C-reactive protein, interleukin, 6 and fibrinogen levels in the two groups (P>0.05). After the treatment, the above levels in both groups decreased compared to their levels before the treatment, and the observation group had significantly lower levels than the control group (P<0.05). Moreover, no significant differences were seen in National Institutes of Health Stroke Scale and modified Rankin Scale scores between the two groups before the treatment (P>0.05). After the treatment, the above scores were decreased in both groups at 1 and 3 months compared to their pre-treatment levels, and the scores were significantly lower in the observation group than they were in the control group at 1 month after the treatment (P<0.05). After a 3-year follow-up, the Kaplan-Meier survival curves demonstrated that the survival times were significantly longer in the observation group than they were in the control group (P<0.05). CONCLUSION: Solitaire stent thrombectomy markedly ameliorates neurological deficits in AISpatients, improves their recanalization rated, regulates the inflammatory response and hemodynamics in the lesion areas, thus exerting favorable short- and long-term clinical effects. AJTR
Authors: Eric L Tung; Ryan A McTaggart; Grayson L Baird; Shadi Yaghi; Morgan Hemendinger; Eleanor L Dibiasio; Douglas T Hidlay; Glenn A Tung; Mahesh V Jayaraman Journal: Stroke Date: 2017-08-03 Impact factor: 7.914
Authors: Andrew M Demchuk; Mayank Goyal; Bijoy K Menon; Muneer Eesa; Karla J Ryckborst; Noreen Kamal; Shivanand Patil; Sachin Mishra; Mohammed Almekhlafi; Privia A Randhawa; Daniel Roy; Robert Willinsky; Walter Montanera; Frank L Silver; Ashfaq Shuaib; Jeremy Rempel; Tudor Jovin; Donald Frei; Biggya Sapkota; J Michael Thornton; Alexandre Poppe; Donatella Tampieri; Cheemun Lum; Alain Weill; Tolulope T Sajobi; Michael D Hill Journal: Int J Stroke Date: 2014-12-25 Impact factor: 5.266
Authors: Mohamad A Hussain; Aziz S Alali; Muhammad Mamdani; Jack V Tu; Gustavo Saposnik; Konard Salata; Avery B Nathens; Charles de Mestral; Deepak L Bhatt; Subodh Verma; Mohammed Al-Omran Journal: J Neurosurg Date: 2018-12-01 Impact factor: 5.115