Weiwen Wu1,2, Tetsuya Asakawa3,4, Qianghong Yang2, Jun Zhao2, Lixia Lu2, Yunhe Luo1, Ping Gong1, Sha Han1, Wei Li1,5, Hiroki Namba3, Liang Wang1,6. 1. a Department of Neurology , Huashan Hospital of Fudan University , Shanghai , People's Republic of China. 2. b Department of Neurology , Qingpu Hospital, Fudan University , Shanghai , People's Republic of China. 3. c Department of Neurosurgery , Hamamatsu University School of Medicine , Hamamatsu , Japan. 4. d Department of Psychiatry , Hamamatsu University School of Medicine , Hamamatsu , Japan. 5. e Huashan Worldwide Medical Center, Huashan Hospital of Fudan University , Shanghai , People's Republic of China. 6. f Institute of Neurology , Huashan Hospital of Fudan University , Shanghai , People's Republic of China.
Abstract
OBJECTIVE: Neuroserpin (NSP) is known for its neuroprotective effects. The aim of this study was to investigate the relationship between NSP level and clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke. METHODS: A total of 133 patients with acute cerebral infarction (ischemia group) and 44 controls were recruited. The modified Rankin Scale (mRS) was used to determine the functional outcome three months after onset. We investigated the relationship between serum NSP levels [on admission and a decrease in NSP levels (10 days after admission versus on admission)] and serum levels of several inflammatory markers. RESULTS: We confirmed that NSP levels on admission in the ischemia group were significantly higher than those in the control group. NSP levels in patients with good outcomes were significantly higher than those in patients with poor outcomes. NSP levels on admission were associated with having a good outcome in these patients. We found that a larger decrease in NSP levels (on admission vs. 10 days after admission) was correlated with lower serum levels of IL-6, IL-1β, and ICAM-1 10 days after admission. CONCLUSIONS: A larger decrease in NSP levels related to lower levels of inflammatory marker, while higher NSP levels were associated with lower inflammatory markers and better functional outcomes. Decreasing the infarct size may play a role in this process. These results provide more evidence of the neuroprotective effect of NSP in cerebral ischemic patients. Decrease in the Serum NSP level and NSP level at admission may be considered as potential predictive factors for outcome of acute ischemic stroke.
OBJECTIVE:Neuroserpin (NSP) is known for its neuroprotective effects. The aim of this study was to investigate the relationship between NSP level and clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke. METHODS: A total of 133 patients with acute cerebral infarction (ischemia group) and 44 controls were recruited. The modified Rankin Scale (mRS) was used to determine the functional outcome three months after onset. We investigated the relationship between serum NSP levels [on admission and a decrease in NSP levels (10 days after admission versus on admission)] and serum levels of several inflammatory markers. RESULTS: We confirmed that NSP levels on admission in the ischemia group were significantly higher than those in the control group. NSP levels in patients with good outcomes were significantly higher than those in patients with poor outcomes. NSP levels on admission were associated with having a good outcome in these patients. We found that a larger decrease in NSP levels (on admission vs. 10 days after admission) was correlated with lower serum levels of IL-6, IL-1β, and ICAM-1 10 days after admission. CONCLUSIONS: A larger decrease in NSP levels related to lower levels of inflammatory marker, while higher NSP levels were associated with lower inflammatory markers and better functional outcomes. Decreasing the infarct size may play a role in this process. These results provide more evidence of the neuroprotective effect of NSP in cerebral ischemicpatients. Decrease in the Serum NSP level and NSP level at admission may be considered as potential predictive factors for outcome of acute ischemic stroke.
Entities:
Keywords:
National Institutes of Health Stroke Scale (NIHSS); Tissue plasminogen activator (tPA); infarct volume; ischemic stroke; logistic regression analysis; neuroserpin
Authors: Daniel Torrente; Enming Joseph Su; Linda Fredriksson; Mark Warnock; David Bushart; Kris M Mann; Cory D Emal; Daniel A Lawrence Journal: Transl Stroke Res Date: 2022-02-04 Impact factor: 6.800