| Literature DB >> 34129837 |
Drake Winslow Williams1, Teresa Greenwell-Wild1, Laurie Brenchley1, Nicolas Dutzan2, Andrew Overmiller3, Andrew Phillip Sawaya3, Simone Webb4, Daniel Martin5, George Hajishengallis6, Kimon Divaris7, Maria Morasso3, Muzlifah Haniffa8, Niki Maria Moutsopoulos9.
Abstract
The oral mucosa remains an understudied barrier tissue. This is a site of rich exposure to antigens and commensals, and a tissue susceptible to one of the most prevalent human inflammatory diseases, periodontitis. To aid in understanding tissue-specific pathophysiology, we compile a single-cell transcriptome atlas of human oral mucosa in healthy individuals and patients with periodontitis. We uncover the complex cellular landscape of oral mucosal tissues and identify epithelial and stromal cell populations with inflammatory signatures that promote antimicrobial defenses and neutrophil recruitment. Our findings link exaggerated stromal cell responsiveness with enhanced neutrophil and leukocyte infiltration in periodontitis. Our work provides a resource characterizing the role of tissue stroma in regulating mucosal tissue homeostasis and disease pathogenesis.Entities:
Keywords: human oral mucosal single-cell atlas; mucosal immunity; oral atlas; oral mucosal immunity; periodontitis single-cell atlas; stromal -immune interaction
Mesh：
Year: 2021 PMID： 34129837 PMCID： PMC8359928 DOI： 10.1016/j.cell.2021.05.013
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 66.850