Andrew Wentzel1, Timothy Luciani2, Lisanne V van Dijk3, Nicolette Taku3, Baher Elgohari4, Abdallah S R Mohamed3, Guadalupe Canahuate5, Clifton D Fuller3, David M Vock6, G Elisabeta Marai7. 1. Department of Computer Science, The University of Illinois at Chicago, Chicago, USA. Electronic address: awentze2@uic.edu. 2. Department of Computer Science, The University of Illinois at Chicago, Chicago, USA. 3. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. 4. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA; Department of Clinical Oncology and Nuclear Medicine, Mansoura University, Mansoura, Egypt. 5. Department of Electrical and Computer Engineering, University of Iowa, Iowa City, USA. 6. Division of Biostatistics, University of Minnesota, Minneapolis, USA. 7. Department of Computer Science, The University of Illinois at Chicago, Chicago, USA. Electronic address: gmarai@uic.edu.
Abstract
PURPOSE: To determine whether patient similarity in terms of head and neck cancer spread through lymph nodes correlates significantly with radiation-associated toxicity. MATERIALS AND METHODS: 582 head and neck cancer patients received radiotherapy for oropharyngeal cancer (OPC) and had non-metastatic affected lymph nodes in the head and neck. Affected lymph nodes were segmented from pretreatment contrast-enhanced tomography scans and categorized according to consensus guidelines. Similar patients were clustered into 4 groups according to a graph-based representation of disease spread through affected lymph nodes. Correlation between dysphagia-associated symptoms and patient groups was calculated. RESULTS: Out of 582 patients, 26% (152) experienced toxicity during a follow up evaluation 6 months after completion of radiotherapy treatment. Patient groups identified by our approach were significantly correlated with dysphagia, feeding tube, and aspiration toxicity (p < .0005). DISCUSSION: Our results suggest that structural geometry-aware characterization of affected lymph nodes can be used to better predict radiation-associated dysphagia at time of diagnosis, and better inform treatment guidelines. CONCLUSION: Our work successfully stratified a patient cohort into similar groups using a structural geometry, graph-encoding of affected lymph nodes in oropharyngeal cancer patients, that were predictive of late radiation-associated dysphagia and toxicity.
PURPOSE: To determine whether patient similarity in terms of head and neck cancer spread through lymph nodes correlates significantly with radiation-associated toxicity. MATERIALS AND METHODS: 582 head and neck cancer patients received radiotherapy for oropharyngeal cancer (OPC) and had non-metastatic affected lymph nodes in the head and neck. Affected lymph nodes were segmented from pretreatment contrast-enhanced tomography scans and categorized according to consensus guidelines. Similar patients were clustered into 4 groups according to a graph-based representation of disease spread through affected lymph nodes. Correlation between dysphagia-associated symptoms and patient groups was calculated. RESULTS: Out of 582 patients, 26% (152) experienced toxicity during a follow up evaluation 6 months after completion of radiotherapy treatment. Patient groups identified by our approach were significantly correlated with dysphagia, feeding tube, and aspiration toxicity (p < .0005). DISCUSSION: Our results suggest that structural geometry-aware characterization of affected lymph nodes can be used to better predict radiation-associated dysphagia at time of diagnosis, and better inform treatment guidelines. CONCLUSION: Our work successfully stratified a patient cohort into similar groups using a structural geometry, graph-encoding of affected lymph nodes in oropharyngeal cancer patients, that were predictive of late radiation-associated dysphagia and toxicity.
Authors: K Kian Ang; Jonathan Harris; Richard Wheeler; Randal Weber; David I Rosenthal; Phuc Felix Nguyen-Tân; William H Westra; Christine H Chung; Richard C Jordan; Charles Lu; Harold Kim; Rita Axelrod; C Craig Silverman; Kevin P Redmond; Maura L Gillison Journal: N Engl J Med Date: 2010-06-07 Impact factor: 91.245
Authors: Vincent Grégoire; Kian Ang; Wilfried Budach; Cai Grau; Marc Hamoir; Johannes A Langendijk; Anne Lee; Quynh-Thu Le; Philippe Maingon; Chris Nutting; Brian O'Sullivan; Sandro V Porceddu; Benoit Lengele Journal: Radiother Oncol Date: 2013-10-31 Impact factor: 6.280
Authors: Brian O'Sullivan; Shao Hui Huang; Jie Su; Adam S Garden; Erich M Sturgis; Kristina Dahlstrom; Nancy Lee; Nadeem Riaz; Xin Pei; Shlomo A Koyfman; David Adelstein; Brian B Burkey; Jeppe Friborg; Claus A Kristensen; Anita B Gothelf; Frank Hoebers; Bernd Kremer; Ernst-Jan Speel; Daniel W Bowles; David Raben; Sana D Karam; Eugene Yu; Wei Xu Journal: Lancet Oncol Date: 2016-02-27 Impact factor: 41.316
Authors: Andrew Wentzel; Peter Hanula; Lisanne V van Dijk; Baher Elgohari; Abdallah S R Mohamed; Carlos E Cardenas; Clifton D Fuller; David M Vock; Guadalupe Canahuate; G E Marai Journal: Radiother Oncol Date: 2020-05-16 Impact factor: 6.280
Authors: Maura L Gillison; Andy M Trotti; Jonathan Harris; Avraham Eisbruch; Paul M Harari; David J Adelstein; Richard C K Jordan; Weiqiang Zhao; Erich M Sturgis; Barbara Burtness; John A Ridge; Jolie Ringash; James Galvin; Min Yao; Shlomo A Koyfman; Dukagjin M Blakaj; Mohammed A Razaq; A Dimitrios Colevas; Jonathan J Beitler; Christopher U Jones; Neal E Dunlap; Samantha A Seaward; Sharon Spencer; Thomas J Galloway; Jack Phan; James J Dignam; Quynh Thu Le Journal: Lancet Date: 2018-11-15 Impact factor: 79.321
Authors: Nam P Nguyen; Cheryl Frank; Candace C Moltz; Ulf Karlsson; Phuc D Nguyen; Harold Wc Ward; Paul Vos; Herbert J Smith; Shawn Huang; Ly M Nguyen; Claire Lemanski; Adir Ludin; Sabah Sallah Journal: Anticancer Res Date: 2009-08 Impact factor: 2.480
Authors: Jeremy Setton; Nancy Y Lee; Nadeem Riaz; Shao-Hui Huang; John Waldron; Brian O'Sullivan; Zhigang Zhang; Weij Shi; David I Rosenthal; Katherine A Hutcheson; Adam S Garden Journal: Cancer Date: 2014-10-06 Impact factor: 6.860
Authors: N P Nguyen; C Frank; C C Moltz; P Vos; H J Smith; P D Nguyen; T Martinez; U Karlsson; S Dutta; C Lemanski; L M Nguyen; S Sallah Journal: Br J Radiol Date: 2009-03-30 Impact factor: 3.039
Authors: Carla Floricel; Nafiul Nipu; Mikayla Biggs; Andrew Wentzel; Guadalupe Canahuate; Lisanne Van Dijk; Abdallah Mohamed; C David Fuller; G Elisabeta Marai Journal: IEEE Trans Vis Comput Graph Date: 2021-12-24 Impact factor: 4.579
Authors: Elisa Tardini; Xinhua Zhang; Guadalupe Canahuate; Andrew Wentzel; Abdallah S R Mohamed; Lisanne Van Dijk; Clifton D Fuller; G Elisabeta Marai Journal: J Med Internet Res Date: 2022-04-20 Impact factor: 7.076