| Literature DB >> 341225 |
A Zmuda, A Dembinska-Kiec, A Chytkowski, R J Gryglewski.
Abstract
Experimental atherosclerosis in rabbits was associated with increased aggregation of their platelets to arachidonic acid, and with increased generation of thromboxane A2 by their platelet-rich plasma. A heightened susceptibility of platelets to the anti-aggregatory action of prostacyclin against the ADP-induced aggregation was also observed. It is concluded that in advance atherosclerosis the platelet system is hypersensitive to biologically active metabolites of arachidonic acid.Entities:
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Year: 1977 PMID： 341225 DOI： 10.1016/0090-6980(77)90283-0
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980