Literature DB >> 6989625

Is the variation in the susceptibility of various species to atherosclerosis due to inborn differences in prostacyclin (PGI2) formation.

H Sinzinger, P Clopath, K Silberbauer, M Winter.   

Abstract

Species exhibiting a higher susceptibility to the development of atherosclerosis have a reduced prostacyclin (PGI2)-generation in the arterial wall, which differs in various parts of the vascular system. As the difference in PGI2-formation in various diseases is a generalized vascular effect, the changes can be detected in all vessels. This is a very important point for diagnostic purposes in humans.

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Year:  1980        PMID： 6989625     DOI： 10.1007/BF01952302

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  23 in total

1.  Formation of prostacyclin (PGl2) by different layers of the arterial wall.

Authors:  A G Herman; S Moncada; J R Vane
Journal:  Arch Int Pharmacodyn Ther       Date:  1977-05

2.  [Prostacyclin--inhibitory effect on thrombocyte aggregation on the vascular wall in vivo?].

Authors:  H Sinzinger; K Silberbauer; M Winter
Journal:  Vasa       Date:  1978       Impact factor: 1.961

3.  Decreased vascular prostacyclin in juvenile-onset diabetes.

Authors:  K Silberbauer; G Schernthaner; H Sinzinger; H Piza-Katzer; M Winter
Journal:  N Engl J Med       Date:  1979-02-15       Impact factor: 91.245

4.  Normal prostacyclin-like activity in vascular tissues from thrombocytopenic rats.

Authors:  S Villa; A Callioni; G de Gaetano
Journal:  Thromb Res       Date:  1977-12       Impact factor: 3.944

5.  Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.

Authors:  S Bunting; R Gryglewski; S Moncada; J R Vane
Journal:  Prostaglandins       Date:  1976-12

6.  Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.

Authors:  R J Gryglewski; S Bunting; S Moncada; R J Flower; J R Vane
Journal:  Prostaglandins       Date:  1976-11

7.  PGI2 production by rat blood vessels: diminished prostacyclin formation in veins compared to arteries.

Authors:  R A Skidgel; M P Printz
Journal:  Prostaglandins       Date:  1978-07

8.  Haemolytic-uraemic syndrome: deficiency of plasma factor(s) regulating prostacyclin activity?

Authors:  G Remuzzi; R Misiani; D Marchesi; M Livio; G Mecca; G de Gaetano; M B Donati
Journal:  Lancet       Date:  1978-10-21       Impact factor: 79.321

9.  Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid.

Authors:  G J Dusting; S Moncada; J R Vane
Journal:  Prostaglandins       Date:  1977-01

10.  Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation.

Authors:  S Moncada; E A Higgs; J R Vane
Journal:  Lancet       Date:  1977-01-01       Impact factor: 79.321
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  2 in total

Review 1.  Role of shear stress and stretch in vascular mechanobiology.

Authors:  Deshun Lu; Ghassan S Kassab
Journal:  J R Soc Interface       Date:  2011-07-06       Impact factor: 4.118

2.  Butter-enriched diets reduce arterial prostacyclin production in rats.

Authors:  K O'Dea; M Steel; J Naughton; A Sinclair; G Hopkins; J Angus; G W He; M Niall; T J Martin
Journal:  Lipids       Date:  1988-03       Impact factor: 1.880
  2 in total

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