Literature DB >> 367809

A triple test for screening biological activity of prostacyclin analogues.

R J Gryglewski, K C Nicolaou.   

Abstract

6,9-Thiaprostacyclin was used as a representative of prostacyclin analogues with the aim to design the most convenient procedure for evaluation of vasodilator, anti-platelet and other biological properties within this new group of potential anti-thrombotic agents.

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Year:  1978        PMID： 367809     DOI： 10.1007/bf01981457

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  The effects of prostagladin endoperoxides and thromboxane A2 on strips of rabbit coeliac artery and certain other smooth muscle preparations [proceedings].

Authors:  S Bunting; S Moncada; J R Vane
Journal:  Br J Pharmacol       Date:  1976-07       Impact factor: 8.739

2.  Synthesis and sterochemistry of prostacyclin and synthesis of 6-ketoprostagliandin F1alpha.

Authors:  R A Johnson; F H Lincoln; J L Thompson; E G Nidy; S A Mizak; U Axen
Journal:  J Am Chem Soc       Date:  1977-06-08       Impact factor: 15.419

3.  The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits.

Authors:  A Dembinska-Kiec; T Gryglewska; A Zmuda; R J Gryglewski
Journal:  Prostaglandins       Date:  1977

4.  Metabolism of prostaglandin endoperoxide in animal tissues.

Authors:  F F Sun; J P Chapman; J C McGuire
Journal:  Prostaglandins       Date:  1977

5.  Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.

Authors:  R J Gryglewski; S Bunting; S Moncada; R J Flower; J R Vane
Journal:  Prostaglandins       Date:  1976-11

6.  An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.

Authors:  S Moncada; R Gryglewski; S Bunting; J R Vane
Journal:  Nature       Date:  1976-10-21       Impact factor: 49.962

7.  Experimental atherosclerosis in rabbits: platelet aggregation, thromboxane A2 generation and anti-aggregatory potency of prostacyclin.

Authors:  A Zmuda; A Dembinska-Kiec; A Chytkowski; R J Gryglewski
Journal:  Prostaglandins       Date:  1977

8.  The continuous estimation of angiotensin formed in the circulation of the dog.

Authors:  D Regoli; J R Vane
Journal:  J Physiol       Date:  1966-04       Impact factor: 5.182

9.  6,9-thiaprostacyclin. A stable and biologically potent analogue of prostacyclin (PGI2)

Authors:  K C Nicolaou; W E Barnette; G P Gasic; R L Magolda
Journal:  J Am Chem Soc       Date:  1977-11-09       Impact factor: 15.419

10.  Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid.

Authors:  G J Dusting; S Moncada; J R Vane
Journal:  Prostaglandins       Date:  1977-01
  10 in total

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