| Literature DB >> 34099940 |
Hannah J Wiedner1,2, Jimena Giudice3,4,5.
Abstract
Biomolecular condensates that form via phase separation are increasingly regarded as coordinators of cellular reactions that regulate a wide variety of biological phenomena. Mounting evidence suggests that multiple steps of the RNA life cycle are organized within RNA-binding protein-rich condensates. In this Review, we discuss recent insights into the influence of phase separation on RNA biology, which has implications for basic cell biology, the pathogenesis of human diseases and the development of novel therapies.Entities:
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Year: 2021 PMID： 34099940 PMCID： PMC8787349 DOI： 10.1038/s41594-021-00601-w
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 18.361