Literature DB >> 27094079

The neurogenetics of alternative splicing.

Celine K Vuong1, Douglas L Black2, Sika Zheng3.   

Abstract

Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal development and the function of mature neurons. We discuss the challenges in understanding the extensive genetic programmes controlled by proteins that regulate splicing, both during development and in the adult brain.

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Year:  2016        PMID： 27094079      PMCID： PMC4861142          DOI： 10.1038/nrn.2016.27

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  208 in total

1.  The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing.

Authors:  Eugene V Makeyev; Jiangwen Zhang; Monica A Carrasco; Tom Maniatis
Journal:  Mol Cell       Date:  2007-08-03       Impact factor: 17.970

2.  Mutation detection in the med and medJ alleles of the sodium channel Scn8a. Unusual splicing due to a minor class AT-AC intron.

Authors:  D C Kohrman; J B Harris; M H Meisler
Journal:  J Biol Chem       Date:  1996-07-19       Impact factor: 5.157

3.  Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells.

Authors:  N W Plummer; M W McBurney; M H Meisler
Journal:  J Biol Chem       Date:  1997-09-19       Impact factor: 5.157

Review 4.  TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration.

Authors:  Clotilde Lagier-Tourenne; Magdalini Polymenidou; Don W Cleveland
Journal:  Hum Mol Genet       Date:  2010-04-15       Impact factor: 6.150

5.  The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite.

Authors:  Claudia Racca; Alejandra Gardiol; Taesun Eom; Jernej Ule; Antoine Triller; Robert B Darnell
Journal:  Front Neural Circuits       Date:  2010-03-03       Impact factor: 3.492

6.  Cochlear inner hair cells exist transiently in the fetal Bronx Waltzer (bv/bv) mouse.

Authors:  D S Whitlon; C Gabel; X Zhang
Journal:  J Comp Neurol       Date:  1996-01-15       Impact factor: 3.215

7.  A targeted deleterious allele of the splicing factor SCNM1 in the mouse.

Authors:  Viive M Howell; Georgius de Haan; Sarah Bergren; Julie M Jones; Cymbeline T Culiat; Edward J Michaud; Wayne N Frankel; Miriam H Meisler
Journal:  Genetics       Date:  2008-09-14       Impact factor: 4.562

8.  Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.

Authors:  Matteo Ruggiu; Ruth Herbst; Natalie Kim; Marko Jevsek; John J Fak; Mary Anne Mann; Gerald Fischbach; Steven J Burden; Robert B Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-12       Impact factor: 11.205

Review 9.  Alternative pre-mRNA splicing in neurons: growing up and extending its reach.

Authors:  Sika Zheng; Douglas L Black
Journal:  Trends Genet       Date:  2013-05-03       Impact factor: 11.639

10.  Motor coordination defects in mice deficient for the Sam68 RNA-binding protein.

Authors:  Kiven E Lukong; Stéphane Richard
Journal:  Behav Brain Res       Date:  2008-02-05       Impact factor: 3.332
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  116 in total

1.  Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.

Authors:  Lin Lin; Min Zhang; Peter Stoilov; Liang Chen; Sika Zheng
Journal:  Neuron       Date:  2020-07-24       Impact factor: 17.173

2.  Stability of Chromatin Remodeling Complex Subunits Is Determined by Their Phosphorylation Status.

Authors:  A M Azieva; A A Sheinov; F A Galkin; S G Georgieva; N V Soshnikova
Journal:  Dokl Biochem Biophys       Date:  2018-05-19       Impact factor: 0.788

3.  Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse.

Authors:  Kyu-Hyeon Yeom; Simon Mitchell; Anthony J Linares; Sika Zheng; Chia-Ho Lin; Xiao-Jun Wang; Alexander Hoffmann; Douglas L Black
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-06       Impact factor: 11.205

Review 4.  DNA Methylation and Susceptibility to Autism Spectrum Disorder.

Authors:  Martine W Tremblay; Yong-Hui Jiang
Journal:  Annu Rev Med       Date:  2019-01-27       Impact factor: 13.739

Review 5.  Microexons: discovery, regulation, and function.

Authors:  Dmytro Ustianenko; Sebastien M Weyn-Vanhentenryck; Chaolin Zhang
Journal:  Wiley Interdiscip Rev RNA       Date:  2017-02-11       Impact factor: 9.957

Review 6.  Alternative splicing programming of axon formation.

Authors:  Sika Zheng
Journal:  Wiley Interdiscip Rev RNA       Date:  2020-01-10       Impact factor: 9.957

7.  PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing.

Authors:  John K Vuong; Chia-Ho Lin; Min Zhang; Liang Chen; Douglas L Black; Sika Zheng
Journal:  Cell Rep       Date:  2016-12-06       Impact factor: 9.423

8.  Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly.

Authors:  Martin Jacko; Sebastien M Weyn-Vanhentenryck; John W Smerdon; Rui Yan; Huijuan Feng; Damian J Williams; Joy Pai; Ke Xu; Hynek Wichterle; Chaolin Zhang
Journal:  Neuron       Date:  2018-02-01       Impact factor: 17.173

9.  USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.

Authors:  Junnosuke Nakamura; Chiharu Hamada; Takumi Taketomi; Jaehyun Kim; Sarasa Yano; Tomomi Okajima; Shin-Ichi Kashiwabara; Tadashi Baba; Ban Sato; Tomoki Chiba; Fuminori Tsuruta
Journal:  Mol Cell Biol       Date:  2020-10-13       Impact factor: 4.272

10.  Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

Authors:  Xiaochang Zhang; Ming Hui Chen; Xuebing Wu; Andrew Kodani; Jean Fan; Ryan Doan; Manabu Ozawa; Jacqueline Ma; Nobuaki Yoshida; Jeremy F Reiter; Douglas L Black; Peter V Kharchenko; Phillip A Sharp; Christopher A Walsh
Journal:  Cell       Date:  2016-08-25       Impact factor: 41.582
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