Literature DB >> 34095799

Bioorthogonal nanozymes: progress towards therapeutic applications.

Xianzhi Zhang1, Rui Huang1, Sanjana Gopalakrishnan1, Roberto Cao-Milán1, Vincent M Rotello1.   

Abstract

Bioorthogonal nanocatalysts in the form of 'nanozymes', are promising tools for generating imaging and therapeutic molecules in living systems. These systems use transformations developed by synthetic chemists to effect transformations that cannot be performed by cellular machinery. This emerging platform is rapidly evolving towards the creation of smart nanodevices featuring the capabilities of their enzyme prototypes, modulating catalytic activity through structure as well as chemical and physical signals. Here we describe different strategies to fabricate these nanocatalysts and their potential in diagnostic and therapeutic applications.

Entities:  

Keywords:  Bioorthogonal chemistry; catalysis; imaging; nanomedicine; nanoparticles; nanozyme

Year:  2019        PMID： 34095799      PMCID： PMC8177485          DOI： 10.1016/j.trechm.2019.02.006

Source DB:  PubMed          Journal:  Trends Chem        ISSN： 2589-5974


  49 in total

1.  Synthesis of polystyrene microspheres and functionalization with Pd(0) nanoparticles to perform bioorthogonal organometallic chemistry in living cells.

Authors:  Asier Unciti-Broceta; Emma M V Johansson; Rahimi M Yusop; Rosario M Sánchez-Martín; Mark Bradley
Journal:  Nat Protoc       Date:  2012-05-31       Impact factor: 13.491

2.  Solubilization of Hydrophobic Catalysts Using Nanoparticle Hosts.

Authors:  Youngdo Jeong; Gulen Yesilbag Tonga; Bradley Duncan; Bo Yan; Riddha Das; Chonticha Sahub; Vincent M Rotello
Journal:  Small       Date:  2017-12-22       Impact factor: 13.281

Review 3.  Designed transition metal catalysts for intracellular organic synthesis.

Authors:  Yugang Bai; Junfeng Chen; Steven C Zimmerman
Journal:  Chem Soc Rev       Date:  2018-03-05       Impact factor: 54.564

4.  Modulating the Catalytic Activity of Enzyme-like Nanoparticles Through their Surface Functionalization.

Authors:  Roberto Cao-Milán; Luke D He; Spencer Shorkey; Gulen Y Tonga; Li-Sheng Wang; Xianzhi Zhang; Imad Uddin; Riddha Das; Mine Sulak; Vincent M Rotello
Journal:  Mol Syst Des Eng       Date:  2017-10-24

5.  Palladium-mediated intracellular chemistry.

Authors:  Rahimi M Yusop; Asier Unciti-Broceta; Emma M V Johansson; Rosario M Sánchez-Martín; Mark Bradley
Journal:  Nat Chem       Date:  2011-02-06       Impact factor: 24.427

6.  Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology: Challenges and Opportunities.

Authors:  Tillmann Heinisch; Thomas R Ward
Journal:  Acc Chem Res       Date:  2016-08-16       Impact factor: 22.384

Review 7.  Metal complex catalysis in living biological systems.

Authors:  Pijus K Sasmal; Craig N Streu; Eric Meggers
Journal:  Chem Commun (Camb)       Date:  2013-02-25       Impact factor: 6.222

8.  Allyl sulfides are privileged substrates in aqueous cross-metathesis: application to site-selective protein modification.

Authors:  Yuya A Lin; Justin M Chalker; Nicola Floyd; Gonçalo J L Bernardes; Benjamin G Davis
Journal:  J Am Chem Soc       Date:  2008-07-01       Impact factor: 15.419

9.  Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine.

Authors:  Jason T Weiss; John C Dawson; Craig Fraser; Witold Rybski; Carmen Torres-Sánchez; Mark Bradley; E Elizabeth Patton; Neil O Carragher; Asier Unciti-Broceta
Journal:  J Med Chem       Date:  2014-06-12       Impact factor: 7.446

10.  A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell.

Authors:  Yasunori Okamoto; Ryosuke Kojima; Fabian Schwizer; Eline Bartolami; Tillmann Heinisch; Stefan Matile; Martin Fussenegger; Thomas R Ward
Journal:  Nat Commun       Date:  2018-05-16       Impact factor: 14.919
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  7 in total

Review 1.  Nanomaterial-based bioorthogonal nanozymes for biological applications.

Authors:  Stefano Fedeli; Jungkyun Im; Sanjana Gopalakrishnan; James L Elia; Aarohi Gupta; Dongkap Kim; Vincent M Rotello
Journal:  Chem Soc Rev       Date:  2021-12-13       Impact factor: 54.564

2.  Erythrocyte-mediated delivery of bioorthogonal nanozymes for selective targeting of bacterial infections.

Authors:  Akash Gupta; Riddha Das; Jessa Marie Makabenta; Aarohi Gupta; Xianzhi Zhang; Taewon Jeon; Rui Huang; Yuanchang Liu; Sanjana Gopalakrishnan; Roberto-Cao Milán; Vincent M Rotello
Journal:  Mater Horiz       Date:  2021-11-29       Impact factor: 13.266

3.  Synthesis of a High Affinity Complementary Peptide-Polymer Nanoparticle (NP) Pair Using Phage Display.

Authors:  Shih-Hui Lee; Issa Moody; Zhiyang Zeng; Everly B Fleischer; Gregory A Weiss; Kenneth J Shea
Journal:  ACS Appl Bio Mater       Date:  2021-02-18

Review 4.  In situ activation of therapeutics through bioorthogonal catalysis.

Authors:  Wenjie Wang; Xianzhi Zhang; Rui Huang; Cristina-Maria Hirschbiegel; Huaisong Wang; Ya Ding; Vincent M Rotello
Journal:  Adv Drug Deliv Rev       Date:  2021-07-29       Impact factor: 17.873

5.  Macrophage-Encapsulated Bioorthogonal Nanozymes for Targeting Cancer Cells.

Authors:  Riddha Das; Joseph Hardie; Bishnu P Joshi; Xianzhi Zhang; Aarohi Gupta; David C Luther; Stefano Fedeli; Michelle E Farkas; Vincent M Rotello
Journal:  JACS Au       Date:  2022-07-07

6.  Bioorthogonal Catalysis for Treatment of Solid Tumors Using Thermostable, Self-Assembling, Single Enzyme Nanoparticles and Natural Product Conversion with Indole-3-acetic Acid.

Authors:  Samira Sadeghi; Nihar D Masurkar; Girish Vallerinteavide Mavelli; Siddharth Deshpande; Warren Kok Yong Tan; Sherman Yee; Shin-Ae Kang; Yoon-Pin Lim; Edward Kai-Hua Chow; Chester L Drum
Journal:  ACS Nano       Date:  2022-06-02       Impact factor: 18.027

7.  Albumin-mediated "Unlocking" of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapy.

Authors:  Jingjing Han; Haidong Li; Luyang Zhao; Gyoungmi Kim; Yahui Chen; Xuehai Yan; Juyoung Yoon
Journal:  Chem Sci       Date:  2022-06-06       Impact factor: 9.969
  7 in total

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