Juana Del Valle-Mendoza1,2, Carlos Palomares-Reyes3, Yordi Tarazona-Castro3,4, Hugo Carrillo-Ng4,5, Sungmin Kym6, Miguel Angel Aguilar-Luis3,4, Luis J Del Valle7, Ronald Aquino-Ortega3,4, Johanna Martins-Luna3,4, Isaac Peña-Tuesta3,4, Eduardo Verne, Wilmer Silva-Caso8,9. 1. School of Medicine, Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. juana.delvalle@upc.pe. 2. Laboratorio de Biologia Molecular, Instituto de Investigación Nutricional, Lima, Peru. juana.delvalle@upc.pe. 3. School of Medicine, Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. 4. Laboratorio de Biologia Molecular, Instituto de Investigación Nutricional, Lima, Peru. 5. Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Perú. 6. Division of Infectious Disease, Department of Internal Medicine, Chungnam National University School of Medicine , Daejeon, Korea. 7. Barcelona Research Center for Multiscale Science and Engineering, Departament D'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya (UPC), Barcelona, Spain. 8. School of Medicine, Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. wilmer.silva@upc.pe. 9. Laboratorio de Biologia Molecular, Instituto de Investigación Nutricional, Lima, Peru. wilmer.silva@upc.pe.
Abstract
OBJECTIVE: This study was carried out to determine the prevalence of leptospirosis among febrile patients with a suspicious clinical diagnosis of dengue fever in northern Peru. RESULTS: A total of 276 serum samples from patients with acute febrile illness (AFI) and suspected diagnosis for dengue virus (DENV) were analyzed. We identified an etiological agent in 121 (47.5%) patients, DENV was detected in 30.4% of the cases, leptospirosis in 11.2% and co-infection by both pathogens was observed in 5.9% of the patients. In this study the most common clinical symptoms reported by the patients were: headache 89.1%, myalgias 86.9% and arthralgias 82.9%. No differences in symptomatology was observed among the different study groups.
OBJECTIVE: This study was carried out to determine the prevalence of leptospirosis among febrile patients with a suspicious clinical diagnosis of dengue fever in northern Peru. RESULTS: A total of 276 serum samples from patients with acute febrile illness (AFI) and suspected diagnosis for dengue virus (DENV) were analyzed. We identified an etiological agent in 121 (47.5%) patients, DENV was detected in 30.4% of the cases, leptospirosis in 11.2% and co-infection by both pathogens was observed in 5.9% of the patients. In this study the most common clinical symptoms reported by the patients were: headache 89.1%, myalgias 86.9% and arthralgias 82.9%. No differences in symptomatology was observed among the different study groups.
Authors: Jorge O Alarcón-Villaverde; Franco Romani-Romani; Romina A Tejada; Paolo Wong-Chero; Manuel Céspedes-Zambrano Journal: Rev Peru Med Exp Salud Publica Date: 2014-04
Authors: Maria G Guzman; Duane J Gubler; Alienys Izquierdo; Eric Martinez; Scott B Halstead Journal: Nat Rev Dis Primers Date: 2016-08-18 Impact factor: 52.329
Authors: Carlos Alva-Urcia; Miguel Angel Aguilar-Luis; Carlos Palomares-Reyes; Wilmer Silva-Caso; Luis Suarez-Ognio; Pablo Weilg; Carlos Manrique; Fernando Vasquez-Achaya; Luis J Del Valle; Juana Del Valle-Mendoza Journal: PLoS One Date: 2017-11-14 Impact factor: 3.240
Authors: Daniel H Libraty; Khin S A Myint; Clinton K Murray; Robert V Gibbons; Mammen P Mammen; Timothy P Endy; Wenjun Li; David W Vaughn; Ananda Nisalak; Siripen Kalayanarooj; Duane R Hospenthal; Sharone Green; Alan L Rothman; Francis A Ennis Journal: PLoS Negl Trop Dis Date: 2007-12-26