Catherine O Buck1, Nan Li2, Charles B Eaton2,3,4, Karl T Kelsey2,5, Kim M Cecil6,7, Heidi J Kalkwarf8, Kimberly Yolton9, Bruce P Lanphear10, Aimin Chen11, Joseph M Braun2. 1. Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA. 2. Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, USA. 3. Department of Family Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, USA. 4. Kent Memorial Hospital, Warwick, Rhode Island, USA. 5. Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA. 6. Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 7. Departments of Pediatrics and Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. 8. Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. 9. Division of General and Community Pediatrics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. 10. Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada. 11. Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract
OBJECTIVE: This study aimed to examine associations of changes in leptin and adiponectin concentrations from birth to age 12 years with adolescent adiposity and cardiometabolic risk in the Health Outcomes and Measures of Environment (HOME) Study, a prospective birth cohort (Cincinnati, Ohio; N = 166). METHODS: Adiposity and cardiometabolic risk factors were assessed at age 12 years using anthropometry, dual-energy x-ray absorptiometry, and fasting serum biomarkers. Cardiometabolic risk scores were calculated by summing age- and sex- standardized z scores for individual cardiometabolic risk factors. RESULTS: Most serum adipocytokine concentrations at birth were not associated with adiposity or cardiometabolic risk outcomes. Leptin and adiponectin concentrations at age 12 years were associated with all outcomes in the expected direction. Adolescents with increasing (β: 4.2; 95% CI: 3.2 to 5.2) and stable (β: 2.2; 95% CI: 1.2 to 3.2) leptin concentrations from birth to age 12 years had higher cardiometabolic risk scores than adolescents with decreasing concentrations (reference group). Adolescents with increasing (e.g., fat mass index = β: -1.04; 95% CI: -1.27 to -0.80) and stable (β: 0.66; 95% CI: -0.92 to -0.40) adiponectin/leptin ratios had more favorable adiposity outcomes than adolescents with decreasing ratios. CONCLUSIONS: In this cohort, changes in leptin concentrations and adiponectin/leptin ratios over childhood were associated with adiposity and cardiometabolic risk scores, indicating that adipocytokine concentrations are potential biomarkers for predicting excess adiposity and cardiometabolic risk in adolescence.
OBJECTIVE: This study aimed to examine associations of changes in leptin and adiponectin concentrations from birth to age 12 years with adolescent adiposity and cardiometabolic risk in the Health Outcomes and Measures of Environment (HOME) Study, a prospective birth cohort (Cincinnati, Ohio; N = 166). METHODS: Adiposity and cardiometabolic risk factors were assessed at age 12 years using anthropometry, dual-energy x-ray absorptiometry, and fasting serum biomarkers. Cardiometabolic risk scores were calculated by summing age- and sex- standardized z scores for individual cardiometabolic risk factors. RESULTS: Most serum adipocytokine concentrations at birth were not associated with adiposity or cardiometabolic risk outcomes. Leptin and adiponectin concentrations at age 12 years were associated with all outcomes in the expected direction. Adolescents with increasing (β: 4.2; 95% CI: 3.2 to 5.2) and stable (β: 2.2; 95% CI: 1.2 to 3.2) leptin concentrations from birth to age 12 years had higher cardiometabolic risk scores than adolescents with decreasing concentrations (reference group). Adolescents with increasing (e.g., fat mass index = β: -1.04; 95% CI: -1.27 to -0.80) and stable (β: 0.66; 95% CI: -0.92 to -0.40) adiponectin/leptin ratios had more favorable adiposity outcomes than adolescents with decreasing ratios. CONCLUSIONS: In this cohort, changes in leptin concentrations and adiponectin/leptin ratios over childhood were associated with adiposity and cardiometabolic risk scores, indicating that adipocytokine concentrations are potential biomarkers for predicting excess adiposity and cardiometabolic risk in adolescence.
Authors: Jennifer A Woo Baidal; Lindsey M Locks; Erika R Cheng; Tiffany L Blake-Lamb; Meghan E Perkins; Elsie M Taveras Journal: Am J Prev Med Date: 2016-02-22 Impact factor: 5.043
Authors: Jennifer A Hutcheon; Robert W Platt; Barbara Abrams; Katherine P Himes; Hyagriv N Simhan; Lisa M Bodnar Journal: Am J Clin Nutr Date: 2013-03-06 Impact factor: 7.045
Authors: Patricia M Guenther; Kellie O Casavale; Jill Reedy; Sharon I Kirkpatrick; Hazel A B Hiza; Kevin J Kuczynski; Lisa L Kahle; Susan M Krebs-Smith Journal: J Acad Nutr Diet Date: 2013-02-13 Impact factor: 4.910