BACKGROUND: Plasma adipocytokines are associated with metabolic profile and cardiovascular risk in obese children. OBJECTIVE: To investigate the association of plasma leptin and adiponectin concentrations with cardiometabolic risk profile and systemic inflammation in non-obese children. SUBJECTS: We studied 170 healthy, non-obese children (86 males, mean age 10±2 years). METHODS: Children's current body mass index (BMI), plasma leptin and adiponectin concentrations, lipid profile, fasting plasma glucose and high sensitivity C reactive protein (hsCRP) were measured. RESULTS: After adjustment for age, gender and BMI, plasma leptin concentrations were positively associated with hsCRP (t=2.72, p=0.009) and fasting plasma glucose (t=4.27, p<0.0001); plasma adiponectin concentrations were negatively associated with hsCRP (t=-3.31, p=0.0016); and positively with high density lipoprotein cholesterol (t=2.32, p=0.02). Children in the highest quartile of leptin/adiponectin (L/A) ratio demonstrated significantly higher BMI, systolic blood pressure, hsCRP, triglycerides and fasting glucose and the lowest high density lipoprotein (HDL) compared to lower L/A ratio quartiles. CONCLUSIONS: Alterations in plasma leptin and adiponectin may help to reclassify non-obese children, detecting those with more unfavorable risk profiles independent of BMI status.
BACKGROUND: Plasma adipocytokines are associated with metabolic profile and cardiovascular risk in obesechildren. OBJECTIVE: To investigate the association of plasma leptin and adiponectin concentrations with cardiometabolic risk profile and systemic inflammation in non-obesechildren. SUBJECTS: We studied 170 healthy, non-obesechildren (86 males, mean age 10±2 years). METHODS:Children's current body mass index (BMI), plasma leptin and adiponectin concentrations, lipid profile, fasting plasma glucose and high sensitivity C reactive protein (hsCRP) were measured. RESULTS: After adjustment for age, gender and BMI, plasma leptin concentrations were positively associated with hsCRP (t=2.72, p=0.009) and fasting plasma glucose (t=4.27, p<0.0001); plasma adiponectin concentrations were negatively associated with hsCRP (t=-3.31, p=0.0016); and positively with high density lipoprotein cholesterol (t=2.32, p=0.02). Children in the highest quartile of leptin/adiponectin (L/A) ratio demonstrated significantly higher BMI, systolic blood pressure, hsCRP, triglycerides and fasting glucose and the lowest high density lipoprotein (HDL) compared to lower L/A ratio quartiles. CONCLUSIONS: Alterations in plasma leptin and adiponectin may help to reclassify non-obesechildren, detecting those with more unfavorable risk profiles independent of BMI status.
Authors: Schuyler J Halverson; Tracy Warhoover; Gregory A Mencio; Steven A Lovejoy; Jeffrey E Martus; Jonathan G Schoenecker Journal: J Bone Joint Surg Am Date: 2017-05-17 Impact factor: 5.284
Authors: Catherine O Buck; Nan Li; Charles B Eaton; Karl T Kelsey; Kim M Cecil; Heidi J Kalkwarf; Kimberly Yolton; Bruce P Lanphear; Aimin Chen; Joseph M Braun Journal: Obesity (Silver Spring) Date: 2021-06 Impact factor: 5.002
Authors: Guoying Wang; Sara Johnson; Yiwei Gong; Sarah Polk; Sara Divall; Sally Radovick; Margaret Moon; David Paige; Xiumei Hong; Deanna Caruso; Zhu Chen; Eric Mallow; Sheila O Walker; Guangyun Mao; Colleen Pearson; Mei-Cheng Wang; Barry Zuckerman; Tina L Cheng; Xiaobin Wang Journal: Sci Rep Date: 2016-07-15 Impact factor: 4.379