Melania Manco1, Graziano Grugni2, Mario Di Pietro3, Antonio Balsamo4, Stefania Di Candia5, Giuseppe Stefano Morino6, Adriana Franzese7, Procolo Di Bonito8, Claudio Maffeis9, Giuliana Valerio10. 1. Area di Ricerca Malattie Multifattoriali, Obesità e Diabete, Ospedale Pediatrico Bambino Gesù, Rome, Italy. melaniamanco@tiscali.it. 2. Divisione di Auxologia, Istituto Auxologico Italiano, Piancavallo, Verbania, Italy. 3. Dipartimento materno-infantile, Ospedale San Liberatore, Atri, Teramo, Italy. 4. Dipartimento di Scienze Mediche e Chirurgiche, Programma di Endocrinologia Pediatrica, Unità Operativa di Pediatria, Università di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy. 5. Dipartimento di Pediatria, Istituto Scientifico San Raffaele, Milano and Azienda Sanitaria Locale 2, Melegnano, Milan, Italy. 6. Area di Ricerca Malattie Multifattoriali, Obesità e Diabete, Ospedale Pediatrico Bambino Gesù, Rome, Italy. 7. Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli Federico II, Naples, Italy. 8. Dipartimento di Medicina Interna, Ospedale Santa Maria delle Grazie, Pozzuoli, Napoli, Italy. 9. Pediatria ad Indirizzo Diabetologico e Malattie del Metabolismo, Università di Verona, Verona, Italy. 10. Dipartimento di Scienze Motorie e del Benessere, Università degli Studi di Napoli Parthenope, Naples, Italy.
Abstract
AIMS: To identify metabolic phenotypes at increased risk of impaired glucose tolerance (IGT) in Italian overweight/obese children (n = 148, age 5-10 years) and adolescents (n = 531, age 10-17.9 year). METHODS: Phenotypes were defined as follows: obesity by the 95th cut-points of the Center for Disease Control body mass index reference standards, impaired fasting glucose (fasting plasma glucose ≥100 mg/dl), high circulating triglycerides (TG), TG/HDL cholesterol ≥2.2, waist-to-height ratio (WTHR) >0.6, and combination of the latter with high TG or TG/HDL cholesterol ≥2.2. RESULTS: In the 148 obese children, TG/HDL-C ≥ 2.2 (OR 20.19; 95 % CI 2.50-163.28, p = 0.005) and the combination of TG/HDL-C ≥ 2.2 and WTHR > 0.60 (OR 14.97; 95 % CI 2.18-102.76, p = 0.006) were significantly associated with IGT. In the 531 adolescents, TG/HDL-C ≥ 2.2 (OR 1.991; 95 % CI 1.243-3.191, p = 0.004) and the combination with WTHR > 0.60 (OR 2.24; 95 % CI 1.29-3.87, p = 0.004) were associated with significantly increased risk of IGT. In the whole sample, having high TG levels according to the NIH National Heart, Lung and Blood Institute Expert Panel was not associated with an increased risk of presenting IGT. CONCLUSIONS: TG/HDL-C ratio can be useful, particularly in children, to identify obese young patients at risk of IGT. Its accuracy as screening tool in a general population needs to be verified. The combination of TG/HDL-C ratio and WTHR > 0.6 did not improve prediction. Having high TG according to the NIH definition was not associated with increased risk of developing IGT.
AIMS: To identify metabolic phenotypes at increased risk of impaired glucose tolerance (IGT) in Italian overweight/obesechildren (n = 148, age 5-10 years) and adolescents (n = 531, age 10-17.9 year). METHODS: Phenotypes were defined as follows: obesity by the 95th cut-points of the Center for Disease Control body mass index reference standards, impaired fasting glucose (fasting plasma glucose ≥100 mg/dl), high circulating triglycerides (TG), TG/HDL cholesterol ≥2.2, waist-to-height ratio (WTHR) >0.6, and combination of the latter with high TG or TG/HDL cholesterol ≥2.2. RESULTS: In the 148 obesechildren, TG/HDL-C ≥ 2.2 (OR 20.19; 95 % CI 2.50-163.28, p = 0.005) and the combination of TG/HDL-C ≥ 2.2 and WTHR > 0.60 (OR 14.97; 95 % CI 2.18-102.76, p = 0.006) were significantly associated with IGT. In the 531 adolescents, TG/HDL-C ≥ 2.2 (OR 1.991; 95 % CI 1.243-3.191, p = 0.004) and the combination with WTHR > 0.60 (OR 2.24; 95 % CI 1.29-3.87, p = 0.004) were associated with significantly increased risk of IGT. In the whole sample, having high TG levels according to the NIH National Heart, Lung and Blood Institute Expert Panel was not associated with an increased risk of presenting IGT. CONCLUSIONS:TG/HDL-C ratio can be useful, particularly in children, to identify obese young patients at risk of IGT. Its accuracy as screening tool in a general population needs to be verified. The combination of TG/HDL-C ratio and WTHR > 0.6 did not improve prediction. Having high TG according to the NIH definition was not associated with increased risk of developing IGT.
Authors: Carmen R Isasi; Christina M Parrinello; Guadalupe X Ayala; Alan M Delamater; Krista M Perreira; Martha L Daviglus; John P Elder; Ashley N Marchante; Shrikant I Bangdiwala; Linda Van Horn; Mercedes R Carnethon Journal: J Pediatr Date: 2016-06-22 Impact factor: 4.406
Authors: Catherine O Buck; Nan Li; Charles B Eaton; Karl T Kelsey; Kim M Cecil; Heidi J Kalkwarf; Kimberly Yolton; Bruce P Lanphear; Aimin Chen; Joseph M Braun Journal: Obesity (Silver Spring) Date: 2021-06 Impact factor: 5.002