| Literature DB >> 33993059 |
Kendra R Vann1, Brianna J Klein1, Tatiana G Kutateladze2.
Abstract
The past two decades have witnessed rapid advances in the identification and characterization of epigenetic readers, capable of recognizing or reading post-translational modifications in histones. More recently, a new set of readers with the ability to interact with the nucleosome through concomitant binding to histones and DNA has emerged. In this review, we discuss mechanistic insights underlying bivalent histone and DNA recognition by newly characterized readers and highlight the importance of binding to DNA for their association with chromatin.Entities:
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Year: 2021 PMID： 33993059 PMCID： PMC8589874 DOI： 10.1016/j.sbi.2021.04.003
Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809