Literature DB >> 3398835

Characterization of Novikoff hepatoma small RNAs homologous to repetitive DNAs.

R Reddy1, D Henning, D Suh.   

Abstract

Three minor small RNA species from Novikoff hepatoma cells, with homology to repetitive DNA sequences, have been identified and characterized. These small RNAs, designated 5.1S, 6S and T3 RNAs, show homology to Alu 1, Alu 2, and Alu 3 sequences, respectively. 6S and T3 RNAs were found both in the nucleus and cytoplasm, whereas 5.1S RNA was not found in the nucleus. Neural tissues were found to contain a 6S-sized BC1 RNA with homology to I.D. sequences; in contrast, the current study shows that Novikoff hepatoma cells contain a 75-80 nucleotide long (T3) RNA, homologous to I.D. sequences. These data suggest that BC1 and T3 small RNAs, homologous to I.D. sequences, are expressed in a tissue-specific manner. These results also show that in addition to the abundant 7SL, 4.5S and 4.5S1 RNAs having homology to repetitive DNA, Novikoff hepatoma cells also contain several minor small RNAs with homology to repetitive sequences.

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Year:  1988        PMID： 3398835     DOI： 10.1007/bf02424554

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  35 in total

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Authors:  J H Rogers
Journal:  Int Rev Cytol       Date:  1985

2.  Biosynthesis and cytoplasmic distribution of small poly(A)-containing B2 RNA.

Authors:  D A Kramerov; S V Tillib; I V Lekakh; A P Ryskov; G P Georgiev
Journal:  Biochim Biophys Acta       Date:  1985-02-20

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Authors:  R A Weinberg; S Penman
Journal:  J Mol Biol       Date:  1968-12       Impact factor: 5.469

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Authors:  S R Haynes; W R Jelinek
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

5.  Are snRNPs involved in splicing?

Authors:  M R Lerner; J A Boyle; S M Mount; S L Wolin; J A Steitz
Journal:  Nature       Date:  1980-01-10       Impact factor: 49.962

6.  Nucleolar antigen found in several human tumors but not in the nontumor tissues studied.

Authors:  F M Davis; F Gyorkey; R K Busch; H Busch
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

7.  Expression of enhanced levels of small RNA polymerase III transcripts encoded by the B2 repeats in simian virus 40-transformed mouse cells.

Authors:  K Singh; M Carey; S Saragosti; M Botchan
Journal:  Nature       Date:  1985 Apr 11-17       Impact factor: 49.962

8.  Small nuclear RNAs from Saccharomyces cerevisiae: unexpected diversity in abundance, size, and molecular complexity.

Authors:  N Riedel; J A Wise; H Swerdlow; A Mak; C Guthrie
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

9.  Low molecular weight RNAs hydrogen-bonded to nuclear and cytoplasmic poly(A)-terminated RNA from cultured Chinese hamster ovary cells.

Authors:  W Jelinek; L Leinwand
Journal:  Cell       Date:  1978-09       Impact factor: 41.582

10.  Human 7SL RNA consists of a 140 nucleotide middle-repetitive sequence inserted in an alu sequence.

Authors:  E Ullu; S Murphy; M Melli
Journal:  Cell       Date:  1982-05       Impact factor: 41.582
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