Literature DB >> 33982586

Neuromodulation in the treatment of postoperative epidural fibrosis: comparison of the extent of epidural fibrosis and the effect of stimulation.

V Masopust1, J Holubová, P Skalický, R Rokyta, J Fricová, J Lacman, D Netuka, J Patríková, K Janoušková.   

Abstract

The goal was to prove that when a cohort of patients is chosen precisely, dorsal column stimulation provides significant improvement to quality of life. We studied a cohort of 50 patients with the history of failed back surgery syndrome coupled with epidural fibrosis (EF). A percutaneous implantation technique was used in each of the 50 patients. The study group was composed of 20 women and 28 men aged 26-67 years (mean age 49). A prospective observational questionnaire-based study was used. According to the methods, Ross's classification was adjusted to four degrees of scar size for our study objective. Despite this adjustment, it was not possible to statistically evaluate our research, due to very similar results in Groups I, III and IV. Patients without epidural fibrosis were assigned to Group 0, and patients with EF of different ranges were assigned to Group 1. The mean change in visual analogue scale DeltaVAS after our division into Group 0 was 4.82; for Group 1 it was 6.13. Evaluation of EF and DeltaVAS correlation by paired t-test shows a statistically higher effect of spinal cord stimulation (SCS) in the epidural fibrosis group, compared to group 0 without postoperative epidural fibrosis (p=0.008). The extent of epidural fibrosis is an important factor for Failed back surgery syndrome (FBSS). FBSS is the basis for the existence of neuropathic pain after lumbar spinal surgery. There is clear evidence of a correlation between patients with epidural scar formation on MR scan and the effect of dorsal column stimulation.

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Year:  2021        PMID: 33982586      PMCID: PMC8820566          DOI: 10.33549/physiolres.934617

Source DB:  PubMed          Journal:  Physiol Res        ISSN: 0862-8408            Impact factor:   1.881


  42 in total

1.  A new material for prevention of epidural fibrosis after laminectomy: oxidized regenerated cellulose (interceed), an absorbable barrier.

Authors:  Sehime G Temel; Cagatay Ozturk; Aytun Temiz; Salim Ersozlu; Ufuk Aydinli
Journal:  J Spinal Disord Tech       Date:  2006-06

2.  [Long-term outcome of patients treated with spinal cord stimulation for therapeutically refractory failed back surgery syndrome: a retrospective study].

Authors:  L Abeloos; O De Witte; R Riquet; T Tuna; N Mathieu
Journal:  Neurochirurgie       Date:  2011-09-09       Impact factor: 1.553

3.  MR evaluation of epidural fibrosis: proposed grading system with intra- and inter-observer variability.

Authors:  J S Ross; N Obuchowski; M T Modic
Journal:  Neurol Res       Date:  1999       Impact factor: 2.448

4.  An analysis of reasons for failed back surgery syndrome and partial results after different types of surgical lumbar nerve root decompression.

Authors:  Andrey Bokov; Alexey Isrelov; Alexander Skorodumov; Alexander Aleynik; Alexander Simonov; Sergey Mlyavykh
Journal:  Pain Physician       Date:  2011 Nov-Dec       Impact factor: 4.965

5.  Spinal cord stimulation attenuates augmented dorsal horn release of excitatory amino acids in mononeuropathy via a GABAergic mechanism.

Authors:  J G Cui; W T O'Connor; U Ungerstedt; B Linderoth; B A Meyerson
Journal:  Pain       Date:  1997-10       Impact factor: 6.961

6.  The glycation products before and after therapy for acute and chronic pain.

Authors:  R Rokyta; J Lejčko; K Houdek; L Trefil; J Nedvídek; J Fricová; V Holeček
Journal:  Physiol Res       Date:  2018-12-31       Impact factor: 1.881

7.  Pain relief by spinal cord stimulation involves serotonergic mechanisms: an experimental study in a rat model of mononeuropathy.

Authors:  Zhiyang Song; Camilla Ultenius; Björn A Meyerson; Bengt Linderoth
Journal:  Pain       Date:  2009-12-15       Impact factor: 6.961

Review 8.  Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: a 20-year literature review.

Authors:  Tracy Cameron
Journal:  J Neurosurg       Date:  2004-03       Impact factor: 5.115

9.  Physiology of spinal cord stimulation: review and update.

Authors:  B Linderoth; R D Foreman
Journal:  Neuromodulation       Date:  1999-07

10.  The Results of Treating Failed Back Surgery Syndrome by Adhesiolysis: Comparing the One- and Three-Day Protocols.

Authors:  Behnam Hossieni; Payman Dadkhah; Siamak Moradi; Seyed Masoud Hashemi; Farshad Safdari
Journal:  Anesth Pain Med       Date:  2017-08-22
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