| Literature DB >> 33972782 |
Leonardo Perez de Souza1, Saleh Alseekh2,3, Federico Scossa2,4, Alisdair R Fernie5,6.
Abstract
Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC-HRMS) variants currently represent the best tools to tackle the challenges of complexity and lack of comprehensive coverage of the metabolome. UHPLC offers flexible and efficient separation coupled with high-sensitivity detection via HRMS, allowing for the detection and identification of a broad range of metabolites. Here we discuss current common strategies for UHPLC-HRMS-based metabolomics, with a focus on expanding metabolome coverage.Year: 2021 PMID: 33972782 DOI: 10.1038/s41592-021-01116-4
Source DB: PubMed Journal: Nat Methods ISSN: 1548-7091 Impact factor: 28.547