Literature DB >> 33972511

Emerging concepts in intestinal immune control of obesity-related metabolic disease.

Saad Khan1,2, Helen Luck2, Shawn Winer3,4, Daniel A Winer5,6,7,8,9.   

Abstract

The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestinal permeability, immune cell trafficking, and intestinal hormone availability, impacting systemic insulin resistance. Understanding these pathways might identify mechanisms underlying treatments for insulin resistance, such as metformin and bariatric surgery, or aid in developing new therapies and vaccination approaches. Here, we highlight evolving concepts centered on intestinal immunity, diet, and the microbiota to provide a working model of obesity-related metabolic disease.

Entities:  

Year:  2021        PMID： 33972511     DOI： 10.1038/s41467-021-22727-7

Source DB:  PubMed          Journal:  Nat Commun        ISSN： 2041-1723            Impact factor:   14.919


  136 in total

Review 1.  Obesity.

Authors:  Pedro González-Muniesa; Miguel-Angel Mártinez-González; Frank B Hu; Jean-Pierre Després; Yuji Matsuzawa; Ruth J F Loos; Luis A Moreno; George A Bray; J Alfredo Martinez
Journal:  Nat Rev Dis Primers       Date:  2017-06-15       Impact factor: 52.329

2.  The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease.

Authors:  Lucile Garidou; Céline Pomié; Pascale Klopp; Aurélie Waget; Julie Charpentier; Meryem Aloulou; Anaïs Giry; Matteo Serino; Lotta Stenman; Sampo Lahtinen; Cedric Dray; Jason S Iacovoni; Michael Courtney; Xavier Collet; Jacques Amar; Florence Servant; Benjamin Lelouvier; Philippe Valet; Gérard Eberl; Nicolas Fazilleau; Victorine Douin-Echinard; Christophe Heymes; Rémy Burcelin
Journal:  Cell Metab       Date:  2015-07-07       Impact factor: 27.287

3.  Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice.

Authors:  Chun-Pyo Hong; Areum Park; Bo-Gie Yang; Chang Ho Yun; Min-Jung Kwak; Gil-Woo Lee; Jung-Hwan Kim; Min Seong Jang; Eun-Jung Lee; Eun-Ji Jeun; Gihoon You; Kwang Soon Kim; Youngwoo Choi; Ji-Hwan Park; Daehee Hwang; Sin-Hyeog Im; Jihyun F Kim; Yoon-Keun Kim; Ju-Young Seoh; Charles D Surh; You-Me Kim; Myoung Ho Jang
Journal:  Gastroenterology       Date:  2017-02-27       Impact factor: 22.682

4.  Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.

Authors:  Helen Luck; Sue Tsai; Jason Chung; Xavier Clemente-Casares; Magar Ghazarian; Xavier S Revelo; Helena Lei; Cynthia T Luk; Sally Yu Shi; Anuradha Surendra; Julia K Copeland; Jennifer Ahn; David Prescott; Brittany A Rasmussen; Melissa Hui Yen Chng; Edgar G Engleman; Stephen E Girardin; Tony K T Lam; Kenneth Croitoru; Shannon Dunn; Dana J Philpott; David S Guttman; Minna Woo; Shawn Winer; Daniel A Winer
Journal:  Cell Metab       Date:  2015-04-07       Impact factor: 27.287

Review 5.  The Intestinal Immune System in Obesity and Insulin Resistance.

Authors:  Daniel A Winer; Helen Luck; Sue Tsai; Shawn Winer
Journal:  Cell Metab       Date:  2016-02-04       Impact factor: 27.287

6.  Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling.

Authors:  Milena Monteiro-Sepulveda; Sothea Touch; Carla Mendes-Sá; Sébastien André; Christine Poitou; Omran Allatif; Aurélie Cotillard; Hélène Fohrer-Ting; Edwige-Ludiwyne Hubert; Romain Remark; Laurent Genser; Joan Tordjman; Kevin Garbin; Céline Osinski; Catherine Sautès-Fridman; Armelle Leturque; Karine Clément; Edith Brot-Laroche
Journal:  Cell Metab       Date:  2015-06-18       Impact factor: 27.287

Review 7.  Adaptive immunity in the host-microbiota dialog.

Authors:  T Feng; C O Elson
Journal:  Mucosal Immunol       Date:  2010-10-13       Impact factor: 7.313

Review 8.  Triggering and resolution of inflammation in NASH.

Authors:  Susanne Schuster; Daniel Cabrera; Marco Arrese; Ariel E Feldstein
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2018-06       Impact factor: 46.802

9.  Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

Authors:  Shun He; Florian Kahles; Sara Rattik; Manfred Nairz; Cameron S McAlpine; Atsushi Anzai; Daniel Selgrade; Ashley M Fenn; Christopher T Chan; John E Mindur; Colin Valet; Wolfram C Poller; Lennard Halle; Noemi Rotllan; Yoshiko Iwamoto; Gregory R Wojtkiewicz; Ralph Weissleder; Peter Libby; Carlos Fernández-Hernando; Daniel J Drucker; Matthias Nahrendorf; Filip K Swirski
Journal:  Nature       Date:  2019-01-30       Impact factor: 49.962

10.  Gut-associated IgA+ immune cells regulate obesity-related insulin resistance.

Authors:  Helen Luck; Saad Khan; Justin H Kim; Julia K Copeland; Xavier S Revelo; Sue Tsai; Mainak Chakraborty; Kathleen Cheng; Yi Tao Chan; Mark K Nøhr; Xavier Clemente-Casares; Marie-Christine Perry; Magar Ghazarian; Helena Lei; Yi-Hsuan Lin; Bryan Coburn; Allan Okrainec; Timothy Jackson; Susan Poutanen; Herbert Gaisano; Johane P Allard; David S Guttman; Margaret E Conner; Shawn Winer; Daniel A Winer
Journal:  Nat Commun       Date:  2019-08-13       Impact factor: 14.919
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  10 in total

Review 1.  Inflammation in obesity, diabetes, and related disorders.

Authors:  Theresa V Rohm; Daniel T Meier; Jerrold M Olefsky; Marc Y Donath
Journal:  Immunity       Date:  2022-01-11       Impact factor: 31.745

2.  Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome.

Authors:  Yoshinaga Kawano; Madeline Edwards; Yiming Huang; Angelina M Bilate; Leandro P Araujo; Takeshi Tanoue; Koji Atarashi; Mark S Ladinsky; Steven L Reiner; Harris H Wang; Daniel Mucida; Kenya Honda; Ivaylo I Ivanov
Journal:  Cell       Date:  2022-08-29       Impact factor: 66.850

Review 3.  The Roles of Adipose Tissue Macrophages in Human Disease.

Authors:  Weizheng Liang; Yanxu Qi; Hongyang Yi; Chenyu Mao; Qingxue Meng; Hao Wang; Chunfu Zheng
Journal:  Front Immunol       Date:  2022-06-09       Impact factor: 8.786

Review 4.  Intestinal Barrier and Permeability in Health, Obesity and NAFLD.

Authors:  Piero Portincasa; Leonilde Bonfrate; Mohamad Khalil; Maria De Angelis; Francesco Maria Calabrese; Mauro D'Amato; David Q-H Wang; Agostino Di Ciaula
Journal:  Biomedicines       Date:  2021-12-31

Review 5.  The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity.

Authors:  Naser A Alsharairi
Journal:  Nutrients       Date:  2021-10-21       Impact factor: 5.717

6.  Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages.

Authors:  Gema Frühbeck; Javier Gómez-Ambrosi; Beatriz Ramírez; Amaia Mentxaka; Amaia Rodríguez; Sara Becerril; Gabriel Reina; Victor Valentí; Rafael Moncada; Camilo Silva; Victoria Catalán
Journal:  Front Immunol       Date:  2022-02-09       Impact factor: 7.561

7.  Jianpi Qinghua Fomula alleviates insulin resistance via restraining of MAPK pathway to suppress inflammation of the small intestine in DIO mice.

Authors:  Yahua Liu; Xu Han; Mengjie Cai; Shenyi Jin; Zihui Yan; Hao Lu; Qingguang Chen
Journal:  BMC Complement Med Ther       Date:  2022-05-09

Review 8.  Gut immune cells-A novel therapeutical target for cardiovascular disease?

Authors:  Naresh Ganesh; Emiel P C van der Vorst; Jens Spiesshöfer; Shun He; Mathias Burgmaier; Hannes Findeisen; Michael Lehrke; Filip K Swirski; Nikolaus Marx; Florian Kahles
Journal:  Front Cardiovasc Med       Date:  2022-08-15

Review 9.  The molecular signaling of exercise and obesity in the microbiota-gut-brain axis.

Authors:  Filipe M Ribeiro; Maycon A Silva; Victória Lyssa; Gabriel Marques; Henny K Lima; Octavio L Franco; Bernardo Petriz
Journal:  Front Endocrinol (Lausanne)       Date:  2022-07-28       Impact factor: 6.055

10.  Protective Effect of Shengmaiyin in Myocardial Hypertrophy-Induced Rats: A Genomic Analysis by 16S rDNA.

Authors:  Sitong Ming; Mo Kan; Liu Liu; Zhuang Zhang; Xiaoran Liu; Yaxin Liu; Zhen Li; Yanhong Zhang; Qihang Pang; Jianan Lin; Hui Li; Qing Yang; Xin Sui; Xiaobo Qu; Na Li
Journal:  Evid Based Complement Alternat Med       Date:  2022-09-07       Impact factor: 2.650
  10 in total

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