Literature DB >> 26853748

The Intestinal Immune System in Obesity and Insulin Resistance.

Daniel A Winer1, Helen Luck2, Sue Tsai3, Shawn Winer4.   

Abstract

Obesity and insulin resistance are associated with chronic inflammation in metabolic tissues such as adipose tissue and the liver. Recently, growing evidence has implicated the intestinal immune system as an important contributor to metabolic disease. Obesity predisposes to altered intestinal immunity and is associated with changes to the gut microbiota, intestinal barrier function, gut-residing innate and adaptive immune cells, and oral tolerance to luminal antigens. Accordingly, the gut immune system may represent a novel therapeutic target for systemic inflammation in insulin resistance. This review discusses the emerging field of intestinal immunity in obesity-related insulin resistance and how it affects metabolic disease.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Year:  2016        PMID： 26853748     DOI： 10.1016/j.cmet.2016.01.003

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  128 in total

1.  TGR5 Protects Against Colitis in Mice, but Vertical Sleeve Gastrectomy Increases Colitis Severity.

Authors:  Darline Garibay; Karolina E Zaborska; Michael Shanahan; Qiaonan Zheng; Katie M Kelly; David C Montrose; Andrew J Dannenberg; Andrew D Miller; Praveen Sethupathy; Bethany P Cummings
Journal:  Obes Surg       Date:  2019-05       Impact factor: 4.129

2.  Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Attenuate Pro-inflammatory Small Intestinal Cytokine Signatures.

Authors:  Renuka Subramaniam; Hassan Aliakbarian; Hina Y Bhutta; David A Harris; Ali Tavakkoli; Eric G Sheu
Journal:  Obes Surg       Date:  2019-12       Impact factor: 4.129

Review 3.  Immunologic impact of the intestine in metabolic disease.

Authors:  Daniel A Winer; Shawn Winer; Helen J Dranse; Tony K T Lam
Journal:  J Clin Invest       Date:  2017-01-03       Impact factor: 14.808

Review 4.  Gut microbiome and chronic prostatitis/chronic pelvic pain syndrome.

Authors:  Hans C Arora; Charis Eng; Daniel A Shoskes
Journal:  Ann Transl Med       Date:  2017-01

Review 5.  Adapting to obesity with adipose tissue inflammation.

Authors:  Shannon M Reilly; Alan R Saltiel
Journal:  Nat Rev Endocrinol       Date:  2017-08-11       Impact factor: 43.330

6.  Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice.

Authors:  Pan Wang; Daotong Li; Weixin Ke; Dong Liang; Xiaosong Hu; Fang Chen
Journal:  Int J Obes (Lond)       Date:  2019-02-04       Impact factor: 5.095

7.  Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health.

Authors:  Jun Zou; Benoit Chassaing; Vishal Singh; Michael Pellizzon; Matthew Ricci; Michael D Fythe; Matam Vijay Kumar; Andrew T Gewirtz
Journal:  Cell Host Microbe       Date:  2017-12-21       Impact factor: 21.023

8.  Introduction for the special issue on recent advances in drug delivery across tissue barriers.

Authors:  Randall J Mrsny; David J Brayden
Journal:  Tissue Barriers       Date:  2016-06-07

Review 9.  Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes.

Authors:  Siddharth Singh; Parambir S Dulai; Amir Zarrinpar; Sonia Ramamoorthy; William J Sandborn
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2016-11-30       Impact factor: 46.802

10.  Uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome activation.

Authors:  Qiulan Lv; Daxing Xu; Jinfeng Ma; Yan Wang; Xiaomin Yang; Peng Zhao; Liang Ma; Zhiyuan Li; Wan Yang; Xiu Liu; Guanpin Yang; Shichao Xing
Journal:  Inflamm Res       Date:  2020-10-19       Impact factor: 4.575
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