Literature DB >> 33972368

Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study.

Xinwei Hua1,2, James Y Dai1,2, Sara Lindström1,2, Tabitha A Harrison1, Yi Lin1, Steven R Alberts3, Elizabeth Alwers4, Sonja I Berndt5, Hermann Brenner4,6,7, Daniel D Buchanan8,9,10, Peter T Campbell11, Graham Casey12, Jenny Chang-Claude13,14, Steven Gallinger15, Graham G Giles16,17,18, Richard M Goldberg19, Marc J Gunter20, Michael Hoffmeister4, Mark A Jenkins17, Amit D Joshi21,22, Wenjie Ma22,23, Roger L Milne16,17,18, Neil Murphy20, Rish K Pai24, Lori C Sakoda1,25, Robert E Schoen26, Qian Shi27, Martha L Slattery28, Mingyang Song22,23,29,30, Emily White1,2, Loic Le Marchand31, Andrew T Chan30,32,33, Ulrike Peters1,2, Polly A Newcomb34,2.   

Abstract

BACKGROUND: A positive association between circulating C-reactive protein (CRP) and colorectal cancer survival was reported in observational studies, which are susceptible to unmeasured confounding and reverse causality. We used a Mendelian randomization approach to evaluate the association between genetically predicted CRP concentrations and colorectal cancer-specific survival.
METHODS: We used individual-level data for 16,918 eligible colorectal cancer cases of European ancestry from 15 studies within the International Survival Analysis of Colorectal Cancer Consortium. We calculated a genetic-risk score based on 52 CRP-associated genetic variants identified from genome-wide association studies. Because of the non-collapsibility of hazard ratios from Cox proportional hazards models, we used the additive hazards model to calculate hazard differences (HD) and 95% confidence intervals (CI) for the association between genetically predicted CRP concentrations and colorectal cancer-specific survival, overall and by stage at diagnosis and tumor location. Analyses were adjusted for age at diagnosis, sex, body mass index, genotyping platform, study, and principal components.
RESULTS: Of the 5,395 (32%) deaths accrued over up to 10 years of follow-up, 3,808 (23%) were due to colorectal cancer. Genetically predicted CRP concentration was not associated with colorectal cancer-specific survival (HD, -1.15; 95% CI, -2.76 to 0.47 per 100,000 person-years; P = 0.16). Similarly, no associations were observed in subgroup analyses by stage at diagnosis or tumor location.
CONCLUSIONS: Despite adequate power to detect moderate associations, our results did not support a causal effect of circulating CRP concentrations on colorectal cancer-specific survival. IMPACT: Future research evaluating genetically determined levels of other circulating inflammatory biomarkers (i.e., IL6) with colorectal cancer survival outcomes is needed. ©2021 American Association for Cancer Research.

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Year:  2021        PMID: 33972368      PMCID: PMC8254760          DOI: 10.1158/1055-9965.EPI-20-1848

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.090


  53 in total

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Review 3.  Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.

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Journal:  Gastroenterology       Date:  2012-12-22       Impact factor: 22.682

4.  The impact of postoperative inflammation on recurrence in patients with colorectal cancer.

Authors:  Daiki Matsubara; Tomohiro Arita; Masayoshi Nakanishi; Yoshiaki Kuriu; Yasutoshi Murayama; Michihiro Kudou; Hirotaka Konishi; Shuhei Komatsu; Atsushi Shiozaki; Eigo Otsuji
Journal:  Int J Clin Oncol       Date:  2019-11-22       Impact factor: 3.402

5.  Serum C-reactive protein correlates with survival in colorectal cancer patients but is not an independent prognostic indicator.

Authors:  Yuan-Chang Chung; Ya-Fen Chang
Journal:  Eur J Gastroenterol Hepatol       Date:  2003-04       Impact factor: 2.566

6.  Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.

Authors:  E Volkova; J A Willis; J E Wells; B A Robinson; G U Dachs; M J Currie
Journal:  Br J Cancer       Date:  2010-11-16       Impact factor: 7.640

7.  Mendelian randomization analysis with multiple genetic variants using summarized data.

Authors:  Stephen Burgess; Adam Butterworth; Simon G Thompson
Journal:  Genet Epidemiol       Date:  2013-09-20       Impact factor: 2.135

8.  Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:  Jeroen R Huyghe; Stephanie A Bien; Tabitha A Harrison; Hyun Min Kang; Sai Chen; Stephanie L Schmit; David V Conti; Conghui Qu; Jihyoun Jeon; Christopher K Edlund; Peyton Greenside; Michael Wainberg; Fredrick R Schumacher; Joshua D Smith; David M Levine; Sarah C Nelson; Nasa A Sinnott-Armstrong; Demetrius Albanes; M Henar Alonso; Kristin Anderson; Coral Arnau-Collell; Volker Arndt; Christina Bamia; Barbara L Banbury; John A Baron; Sonja I Berndt; Stéphane Bézieau; D Timothy Bishop; Juergen Boehm; Heiner Boeing; Hermann Brenner; Stefanie Brezina; Stephan Buch; Daniel D Buchanan; Andrea Burnett-Hartman; Katja Butterbach; Bette J Caan; Peter T Campbell; Christopher S Carlson; Sergi Castellví-Bel; Andrew T Chan; Jenny Chang-Claude; Stephen J Chanock; Maria-Dolores Chirlaque; Sang Hee Cho; Charles M Connolly; Amanda J Cross; Katarina Cuk; Keith R Curtis; Albert de la Chapelle; Kimberly F Doheny; David Duggan; Douglas F Easton; Sjoerd G Elias; Faye Elliott; Dallas R English; Edith J M Feskens; Jane C Figueiredo; Rocky Fischer; Liesel M FitzGerald; David Forman; Manish Gala; Steven Gallinger; W James Gauderman; Graham G Giles; Elizabeth Gillanders; Jian Gong; Phyllis J Goodman; William M Grady; John S Grove; Andrea Gsur; Marc J Gunter; Robert W Haile; Jochen Hampe; Heather Hampel; Sophia Harlid; Richard B Hayes; Philipp Hofer; Michael Hoffmeister; John L Hopper; Wan-Ling Hsu; Wen-Yi Huang; Thomas J Hudson; David J Hunter; Gemma Ibañez-Sanz; Gregory E Idos; Roxann Ingersoll; Rebecca D Jackson; Eric J Jacobs; Mark A Jenkins; Amit D Joshi; Corinne E Joshu; Temitope O Keku; Timothy J Key; Hyeong Rok Kim; Emiko Kobayashi; Laurence N Kolonel; Charles Kooperberg; Tilman Kühn; Sébastien Küry; Sun-Seog Kweon; Susanna C Larsson; Cecelia A Laurie; Loic Le Marchand; Suzanne M Leal; Soo Chin Lee; Flavio Lejbkowicz; Mathieu Lemire; Christopher I Li; Li Li; Wolfgang Lieb; Yi Lin; Annika Lindblom; Noralane M Lindor; Hua Ling; Tin L Louie; Satu Männistö; Sanford D Markowitz; Vicente Martín; Giovanna Masala; Caroline E McNeil; Marilena Melas; Roger L Milne; Lorena Moreno; Neil Murphy; Robin Myte; Alessio Naccarati; Polly A Newcomb; Kenneth Offit; Shuji Ogino; N Charlotte Onland-Moret; Barbara Pardini; Patrick S Parfrey; Rachel Pearlman; Vittorio Perduca; Paul D P Pharoah; Mila Pinchev; Elizabeth A Platz; Ross L Prentice; Elizabeth Pugh; Leon Raskin; Gad Rennert; Hedy S Rennert; Elio Riboli; Miguel Rodríguez-Barranco; Jane Romm; Lori C Sakoda; Clemens Schafmayer; Robert E Schoen; Daniela Seminara; Mitul Shah; Tameka Shelford; Min-Ho Shin; Katerina Shulman; Sabina Sieri; Martha L Slattery; Melissa C Southey; Zsofia K Stadler; Christa Stegmaier; Yu-Ru Su; Catherine M Tangen; Stephen N Thibodeau; Duncan C Thomas; Sushma S Thomas; Amanda E Toland; Antonia Trichopoulou; Cornelia M Ulrich; David J Van Den Berg; Franzel J B van Duijnhoven; Bethany Van Guelpen; Henk van Kranen; Joseph Vijai; Kala Visvanathan; Pavel Vodicka; Ludmila Vodickova; Veronika Vymetalkova; Korbinian Weigl; Stephanie J Weinstein; Emily White; Aung Ko Win; C Roland Wolf; Alicja Wolk; Michael O Woods; Anna H Wu; Syed H Zaidi; Brent W Zanke; Qing Zhang; Wei Zheng; Peter C Scacheri; John D Potter; Michael C Bassik; Anshul Kundaje; Graham Casey; Victor Moreno; Goncalo R Abecasis; Deborah A Nickerson; Stephen B Gruber; Li Hsu; Ulrike Peters
Journal:  Nat Genet       Date:  2018-12-03       Impact factor: 41.307

9.  Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

Authors:  Symen Ligthart; Ahmad Vaez; Urmo Võsa; Maria G Stathopoulou; Paul S de Vries; Bram P Prins; Peter J Van der Most; Toshiko Tanaka; Elnaz Naderi; Lynda M Rose; Ying Wu; Robert Karlsson; Maja Barbalic; Honghuang Lin; René Pool; Gu Zhu; Aurélien Macé; Carlo Sidore; Stella Trompet; Massimo Mangino; Maria Sabater-Lleal; John P Kemp; Ali Abbasi; Tim Kacprowski; Niek Verweij; Albert V Smith; Tao Huang; Carola Marzi; Mary F Feitosa; Kurt K Lohman; Marcus E Kleber; Yuri Milaneschi; Christian Mueller; Mahmudul Huq; Efthymia Vlachopoulou; Leo-Pekka Lyytikäinen; Christopher Oldmeadow; Joris Deelen; Markus Perola; Jing Hua Zhao; Bjarke Feenstra; Marzyeh Amini; Jari Lahti; Katharina E Schraut; Myriam Fornage; Bhoom Suktitipat; Wei-Min Chen; Xiaohui Li; Teresa Nutile; Giovanni Malerba; Jian'an Luan; Tom Bak; Nicholas Schork; Fabiola Del Greco M; Elisabeth Thiering; Anubha Mahajan; Riccardo E Marioni; Evelin Mihailov; Joel Eriksson; Ayse Bilge Ozel; Weihua Zhang; Maria Nethander; Yu-Ching Cheng; Stella Aslibekyan; Wei Ang; Ilaria Gandin; Loïc Yengo; Laura Portas; Charles Kooperberg; Edith Hofer; Kumar B Rajan; Claudia Schurmann; Wouter den Hollander; Tarunveer S Ahluwalia; Jing Zhao; Harmen H M Draisma; Ian Ford; Nicholas Timpson; Alexander Teumer; Hongyan Huang; Simone Wahl; YongMei Liu; Jie Huang; Hae-Won Uh; Frank Geller; Peter K Joshi; Lisa R Yanek; Elisabetta Trabetti; Benjamin Lehne; Diego Vozzi; Marie Verbanck; Ginevra Biino; Yasaman Saba; Ingrid Meulenbelt; Jeff R O'Connell; Markku Laakso; Franco Giulianini; Patrik K E Magnusson; Christie M Ballantyne; Jouke Jan Hottenga; Grant W Montgomery; Fernando Rivadineira; Rico Rueedi; Maristella Steri; Karl-Heinz Herzig; David J Stott; Cristina Menni; Mattias Frånberg; Beate St Pourcain; Stephan B Felix; Tune H Pers; Stephan J L Bakker; Peter Kraft; Annette Peters; Dhananjay Vaidya; Graciela Delgado; Johannes H Smit; Vera Großmann; Juha Sinisalo; Ilkka Seppälä; Stephen R Williams; Elizabeth G Holliday; Matthijs Moed; Claudia Langenberg; Katri Räikkönen; Jingzhong Ding; Harry Campbell; Michele M Sale; Yii-Der I Chen; Alan L James; Daniela Ruggiero; Nicole Soranzo; Catharina A Hartman; Erin N Smith; Gerald S Berenson; Christian Fuchsberger; Dena Hernandez; Carla M T Tiesler; Vilmantas Giedraitis; David Liewald; Krista Fischer; Dan Mellström; Anders Larsson; Yunmei Wang; William R Scott; Matthias Lorentzon; John Beilby; Kathleen A Ryan; Craig E Pennell; Dragana Vuckovic; Beverly Balkau; Maria Pina Concas; Reinhold Schmidt; Carlos F Mendes de Leon; Erwin P Bottinger; Margreet Kloppenburg; Lavinia Paternoster; Michael Boehnke; A W Musk; Gonneke Willemsen; David M Evans; Pamela A F Madden; Mika Kähönen; Zoltán Kutalik; Magdalena Zoledziewska; Ville Karhunen; Stephen B Kritchevsky; Naveed Sattar; Genevieve Lachance; Robert Clarke; Tamara B Harris; Olli T Raitakari; John R Attia; Diana van Heemst; Eero Kajantie; Rossella Sorice; Giovanni Gambaro; Robert A Scott; Andrew A Hicks; Luigi Ferrucci; Marie Standl; Cecilia M Lindgren; John M Starr; Magnus Karlsson; Lars Lind; Jun Z Li; John C Chambers; Trevor A Mori; Eco J C N de Geus; Andrew C Heath; Nicholas G Martin; Juha Auvinen; Brendan M Buckley; Anton J M de Craen; Melanie Waldenberger; Konstantin Strauch; Thomas Meitinger; Rodney J Scott; Mark McEvoy; Marian Beekman; Cristina Bombieri; Paul M Ridker; Karen L Mohlke; Nancy L Pedersen; Alanna C Morrison; Dorret I Boomsma; John B Whitfield; David P Strachan; Albert Hofman; Peter Vollenweider; Francesco Cucca; Marjo-Riitta Jarvelin; J Wouter Jukema; Tim D Spector; Anders Hamsten; Tanja Zeller; André G Uitterlinden; Matthias Nauck; Vilmundur Gudnason; Lu Qi; Harald Grallert; Ingrid B Borecki; Jerome I Rotter; Winfried März; Philipp S Wild; Marja-Liisa Lokki; Michael Boyle; Veikko Salomaa; Mads Melbye; Johan G Eriksson; James F Wilson; Brenda W J H Penninx; Diane M Becker; Bradford B Worrall; Greg Gibson; Ronald M Krauss; Marina Ciullo; Gianluigi Zaza; Nicholas J Wareham; Albertine J Oldehinkel; Lyle J Palmer; Sarah S Murray; Peter P Pramstaller; Stefania Bandinelli; Joachim Heinrich; Erik Ingelsson; Ian J Deary; Reedik Mägi; Liesbeth Vandenput; Pim van der Harst; Karl C Desch; Jaspal S Kooner; Claes Ohlsson; Caroline Hayward; Terho Lehtimäki; Alan R Shuldiner; Donna K Arnett; Lawrence J Beilin; Antonietta Robino; Philippe Froguel; Mario Pirastu; Tine Jess; Wolfgang Koenig; Ruth J F Loos; Denis A Evans; Helena Schmidt; George Davey Smith; P Eline Slagboom; Gudny Eiriksdottir; Andrew P Morris; Bruce M Psaty; Russell P Tracy; Ilja M Nolte; Eric Boerwinkle; Sophie Visvikis-Siest; Alex P Reiner; Myron Gross; Joshua C Bis; Lude Franke; Oscar H Franco; Emelia J Benjamin; Daniel I Chasman; Josée Dupuis; Harold Snieder; Abbas Dehghan; Behrooz Z Alizadeh
Journal:  Am J Hum Genet       Date:  2018-11-01       Impact factor: 11.025

10.  Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.

Authors:  Jack Bowden; George Davey Smith; Philip C Haycock; Stephen Burgess
Journal:  Genet Epidemiol       Date:  2016-04-07       Impact factor: 2.135

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  2 in total

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Journal:  BMC Cancer       Date:  2022-06-24       Impact factor: 4.638

2.  Association Between Genetic Predictors for C-Reactive Protein and Venous Thromboembolism With Severe Adverse Coronavirus Disease 2019 Outcomes.

Authors:  Boya Guo; Jessica Williams-Nguyen; Lu Wang; Cameron B Haas; Christopher Kabrhel; Sara Lindström
Journal:  Crit Care Explor       Date:  2021-12-20
  2 in total

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