Randy P Auerbach1, David Pagliaccio2, Nicholas A Hubbard3, Isabelle Frosch4, Rebecca Kremens5, Elizabeth Cosby5, Robert Jones6, Viviana Siless6, Nicole Lo4, Aude Henin7, Stefan G Hofmann8, John D E Gabrieli4, Anastasia Yendiki9, Susan Whitfield-Gabrieli10, Diego A Pizzagalli11. 1. Columbia University, New York; New York State Psychiatric Institute, New York; Division of Clinical Developmental Neuroscience, Sackler Institute, New York. Electronic address: rpa2009@cumc.columbia.edu. 2. Columbia University, New York; New York State Psychiatric Institute, New York. 3. Massachusetts Institute of Technology, Cambridge, Massachusetts; University of Nebraska, Lincoln. 4. Massachusetts Institute of Technology, Cambridge, Massachusetts. 5. Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts. 6. Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston; Harvard Medical School, Boston, Massachusetts. 7. Harvard Medical School, Boston, Massachusetts; Massachusetts General Hospital, Boston, Massachusetts. 8. Boston University, Massachusetts. 9. Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston; Massachusetts General Hospital, Boston, Massachusetts. 10. Northeastern University, Boston, Massachusetts. 11. Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Abstract
OBJECTIVE: Although depression and anxiety often have distinct etiologies, they frequently co-occur in adolescence. Recent initiatives have underscored the importance of developing new ways of classifying mental illness based on underlying neural dimensions that cut across traditional diagnostic boundaries. Accordingly, the aim of the study was to clarify reward-related neural circuitry that may characterize depressed-anxious youth. METHOD: The Boston Adolescent Neuroimaging of Depression and Anxiety Human Connectome Project tested group differences regarding subcortical volume and nucleus accumbens activation during an incentive processing task among 14- to 17-year-old adolescents presenting with a primary depressive and/or anxiety disorder (n = 129) or no lifetime history of mental disorders (n = 64). In addition, multimodal modeling examined predictors of depression and anxiety symptom change over a 6-month follow-up period. RESULTS: Our findings highlighted considerable convergence. Relative to healthy youth, depressed-anxious adolescents exhibited reduced nucleus accumbens volume and activation following reward receipt. These findings remained when removing all medicated participants (∼59% of depressed-anxious youth). Subgroup analyses comparing anxious-only, depressed-anxious, and healthy youth also were largely consistent. Multimodal modeling showed that only structural alterations predicted depressive symptoms over time. CONCLUSION: Multimodal findings highlight alterations within nucleus accumbens structure and function that characterize depressed-anxious adolescents. In the current hypothesis-driven analyses, however, only reduced nucleus accumbens volume predicted depressive symptoms over time. An important next step will be to clarify why structural alterations have an impact on reward-related processes and associated symptoms.
OBJECTIVE: Although depression and anxiety often have distinct etiologies, they frequently co-occur in adolescence. Recent initiatives have underscored the importance of developing new ways of classifying mental illness based on underlying neural dimensions that cut across traditional diagnostic boundaries. Accordingly, the aim of the study was to clarify reward-related neural circuitry that may characterize depressed-anxious youth. METHOD: The Boston Adolescent Neuroimaging of Depression and Anxiety Human Connectome Project tested group differences regarding subcortical volume and nucleus accumbens activation during an incentive processing task among 14- to 17-year-old adolescents presenting with a primary depressive and/or anxiety disorder (n = 129) or no lifetime history of mental disorders (n = 64). In addition, multimodal modeling examined predictors of depression and anxiety symptom change over a 6-month follow-up period. RESULTS: Our findings highlighted considerable convergence. Relative to healthy youth, depressed-anxious adolescents exhibited reduced nucleus accumbens volume and activation following reward receipt. These findings remained when removing all medicated participants (∼59% of depressed-anxious youth). Subgroup analyses comparing anxious-only, depressed-anxious, and healthy youth also were largely consistent. Multimodal modeling showed that only structural alterations predicted depressive symptoms over time. CONCLUSION: Multimodal findings highlight alterations within nucleus accumbens structure and function that characterize depressed-anxious adolescents. In the current hypothesis-driven analyses, however, only reduced nucleus accumbens volume predicted depressive symptoms over time. An important next step will be to clarify why structural alterations have an impact on reward-related processes and associated symptoms.
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Authors: Viviana Siless; Nicholas A Hubbard; Robert Jones; Jonathan Wang; Nicole Lo; Clemens C C Bauer; Mathias Goncalves; Isabelle Frosch; Daniel Norton; Genesis Vergara; Kristina Conroy; Flavia Vaz De Souza; Isabelle M Rosso; Aleena Hay Wickham; Elizabeth Ann Cosby; Megan Pinaire; Dina Hirshfeld-Becker; Diego A Pizzagalli; Aude Henin; Stefan G Hofmann; Randy P Auerbach; Satrajit Ghosh; John Gabrieli; Susan Whitfield-Gabrieli; Anastasia Yendiki Journal: Neuroimage Clin Date: 2020-03-19 Impact factor: 4.881
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