Literature DB >> 33958779

Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney.

James M Eales1, Xiao Jiang1, Xiaoguang Xu1, Sushant Saluja1, Artur Akbarov1, Eddie Cano-Gamez2, Michelle T McNulty3,4, Christopher Finan5, Hui Guo6, Wojciech Wystrychowski7, Monika Szulinska8, Huw B Thomas9, Sanjeev Pramanik1,10, Sandesh Chopade5, Priscilla R Prestes11, Ingrid Wise12, Evangelos Evangelou13,14, Mahan Salehi1, Yusif Shakanti1, Mikael Ekholm1,15, Matthew Denniff16, Alicja Nazgiewicz1, Felix Eichinger17, Bradley Godfrey18, Andrzej Antczak18, Maciej Glyda19, Robert Król7, Stephen Eyre20, Jason Brown21, Carlo Berzuini6, John Bowes20, Mark Caulfield22,23, Ewa Zukowska-Szczechowska24, Joanna Zywiec25, Pawel Bogdanski8, Matthias Kretzler17, Adrian S Woolf26,27, David Talavera1, Bernard Keavney1,28, Pasquale Maffia29,30,31, Tomasz J Guzik30,32, Raymond T O'Keefe9, Gosia Trynka2,33, Nilesh J Samani16,34, Aroon Hingorani5, Matthew G Sampson3,4,35, Andrew P Morris20,36, Fadi J Charchar11,16,37, Maciej Tomaszewski38,39.   

Abstract

The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and antihypertensive treatment. However, genetically mediated renal mechanisms underlying susceptibility to hypertension remain poorly understood. We integrated genotype, gene expression, alternative splicing and DNA methylation profiles of up to 430 human kidneys to characterize the effects of BP index variants from genome-wide association studies (GWASs) on renal transcriptome and epigenome. We uncovered kidney targets for 479 (58.3%) BP-GWAS variants and paired 49 BP-GWAS kidney genes with 210 licensed drugs. Our colocalization and Mendelian randomization analyses identified 179 unique kidney genes with evidence of putatively causal effects on BP. Through Mendelian randomization, we also uncovered effects of BP on renal outcomes commonly affecting patients with hypertension. Collectively, our studies identified genetic variants, kidney genes, molecular mechanisms and biological pathways of key relevance to the genetic regulation of BP and inherited susceptibility to hypertension.

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Mesh：

Year:  2021        PMID： 33958779     DOI： 10.1038/s41588-021-00835-w

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   41.307


  112 in total

Review 1.  The genetics of blood pressure and hypertension: the role of rare variation.

Authors:  Peter A Doris
Journal:  Cardiovasc Ther       Date:  2010-12-06       Impact factor: 3.023

2.  A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

Authors:  Stephen S Lim; Theo Vos; Abraham D Flaxman; Goodarz Danaei; Kenji Shibuya; Heather Adair-Rohani; Markus Amann; H Ross Anderson; Kathryn G Andrews; Martin Aryee; Charles Atkinson; Loraine J Bacchus; Adil N Bahalim; Kalpana Balakrishnan; John Balmes; Suzanne Barker-Collo; Amanda Baxter; Michelle L Bell; Jed D Blore; Fiona Blyth; Carissa Bonner; Guilherme Borges; Rupert Bourne; Michel Boussinesq; Michael Brauer; Peter Brooks; Nigel G Bruce; Bert Brunekreef; Claire Bryan-Hancock; Chiara Bucello; Rachelle Buchbinder; Fiona Bull; Richard T Burnett; Tim E Byers; Bianca Calabria; Jonathan Carapetis; Emily Carnahan; Zoe Chafe; Fiona Charlson; Honglei Chen; Jian Shen Chen; Andrew Tai-Ann Cheng; Jennifer Christine Child; Aaron Cohen; K Ellicott Colson; Benjamin C Cowie; Sarah Darby; Susan Darling; Adrian Davis; Louisa Degenhardt; Frank Dentener; Don C Des Jarlais; Karen Devries; Mukesh Dherani; Eric L Ding; E Ray Dorsey; Tim Driscoll; Karen Edmond; Suad Eltahir Ali; Rebecca E Engell; Patricia J Erwin; Saman Fahimi; Gail Falder; Farshad Farzadfar; Alize Ferrari; Mariel M Finucane; Seth Flaxman; Francis Gerry R Fowkes; Greg Freedman; Michael K Freeman; Emmanuela Gakidou; Santu Ghosh; Edward Giovannucci; Gerhard Gmel; Kathryn Graham; Rebecca Grainger; Bridget Grant; David Gunnell; Hialy R Gutierrez; Wayne Hall; Hans W Hoek; Anthony Hogan; H Dean Hosgood; Damian Hoy; Howard Hu; Bryan J Hubbell; Sally J Hutchings; Sydney E Ibeanusi; Gemma L Jacklyn; Rashmi Jasrasaria; Jost B Jonas; Haidong Kan; John A Kanis; Nicholas Kassebaum; Norito Kawakami; Young-Ho Khang; Shahab Khatibzadeh; Jon-Paul Khoo; Cindy Kok; Francine Laden; Ratilal Lalloo; Qing Lan; Tim Lathlean; Janet L Leasher; James Leigh; Yang Li; John Kent Lin; Steven E Lipshultz; Stephanie London; Rafael Lozano; Yuan Lu; Joelle Mak; Reza Malekzadeh; Leslie Mallinger; Wagner Marcenes; Lyn March; Robin Marks; Randall Martin; Paul McGale; John McGrath; Sumi Mehta; George A Mensah; Tony R Merriman; Renata Micha; Catherine Michaud; Vinod Mishra; Khayriyyah Mohd Hanafiah; Ali A Mokdad; Lidia Morawska; Dariush Mozaffarian; Tasha Murphy; Mohsen Naghavi; Bruce Neal; Paul K Nelson; Joan Miquel Nolla; Rosana Norman; Casey Olives; Saad B Omer; Jessica Orchard; Richard Osborne; Bart Ostro; Andrew Page; Kiran D Pandey; Charles D H Parry; Erin Passmore; Jayadeep Patra; Neil Pearce; Pamela M Pelizzari; Max Petzold; Michael R Phillips; Dan Pope; C Arden Pope; John Powles; Mayuree Rao; Homie Razavi; Eva A Rehfuess; Jürgen T Rehm; Beate Ritz; Frederick P Rivara; Thomas Roberts; Carolyn Robinson; Jose A Rodriguez-Portales; Isabelle Romieu; Robin Room; Lisa C Rosenfeld; Ananya Roy; Lesley Rushton; Joshua A Salomon; Uchechukwu Sampson; Lidia Sanchez-Riera; Ella Sanman; Amir Sapkota; Soraya Seedat; Peilin Shi; Kevin Shield; Rupak Shivakoti; Gitanjali M Singh; David A Sleet; Emma Smith; Kirk R Smith; Nicolas J C Stapelberg; Kyle Steenland; Heidi Stöckl; Lars Jacob Stovner; Kurt Straif; Lahn Straney; George D Thurston; Jimmy H Tran; Rita Van Dingenen; Aaron van Donkelaar; J Lennert Veerman; Lakshmi Vijayakumar; Robert Weintraub; Myrna M Weissman; Richard A White; Harvey Whiteford; Steven T Wiersma; James D Wilkinson; Hywel C Williams; Warwick Williams; Nicholas Wilson; Anthony D Woolf; Paul Yip; Jan M Zielinski; Alan D Lopez; Christopher J L Murray; Majid Ezzati; Mohammad A AlMazroa; Ziad A Memish
Journal:  Lancet       Date:  2012-12-15       Impact factor: 79.321

3.  May Measurement Month 2017: an analysis of blood pressure screening results worldwide.

Authors:  Thomas Beaney; Aletta E Schutte; Maciej Tomaszewski; Cono Ariti; Louise M Burrell; Rafael R Castillo; Fadi J Charchar; Albertino Damasceno; Ruan Kruger; Daniel T Lackland; Peter M Nilsson; Dorairaj Prabhakaran; Agustin J Ramirez; Markus P Schlaich; Jiguang Wang; Michael A Weber; Neil R Poulter
Journal:  Lancet Glob Health       Date:  2018-05-16       Impact factor: 26.763

Review 4.  Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics.

Authors:  Claudia P Cabrera; Fu Liang Ng; Helen R Warren; Michael R Barnes; Patricia B Munroe; Mark J Caulfield
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2015-02-06

5.  Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Authors:  Georg B Ehret; Patricia B Munroe; Kenneth M Rice; Murielle Bochud; Andrew D Johnson; Daniel I Chasman; Albert V Smith; Martin D Tobin; Germaine C Verwoert; Shih-Jen Hwang; Vasyl Pihur; Peter Vollenweider; Paul F O'Reilly; Najaf Amin; Jennifer L Bragg-Gresham; Alexander Teumer; Nicole L Glazer; Lenore Launer; Jing Hua Zhao; Yurii Aulchenko; Simon Heath; Siim Sõber; Afshin Parsa; Jian'an Luan; Pankaj Arora; Abbas Dehghan; Feng Zhang; Gavin Lucas; Andrew A Hicks; Anne U Jackson; John F Peden; Toshiko Tanaka; Sarah H Wild; Igor Rudan; Wilmar Igl; Yuri Milaneschi; Alex N Parker; Cristiano Fava; John C Chambers; Ervin R Fox; Meena Kumari; Min Jin Go; Pim van der Harst; Wen Hong Linda Kao; Marketa Sjögren; D G Vinay; Myriam Alexander; Yasuharu Tabara; Sue Shaw-Hawkins; Peter H Whincup; Yongmei Liu; Gang Shi; Johanna Kuusisto; Bamidele Tayo; Mark Seielstad; Xueling Sim; Khanh-Dung Hoang Nguyen; Terho Lehtimäki; Giuseppe Matullo; Ying Wu; Tom R Gaunt; N Charlotte Onland-Moret; Matthew N Cooper; Carl G P Platou; Elin Org; Rebecca Hardy; Santosh Dahgam; Jutta Palmen; Veronique Vitart; Peter S Braund; Tatiana Kuznetsova; Cuno S P M Uiterwaal; Adebowale Adeyemo; Walter Palmas; Harry Campbell; Barbara Ludwig; Maciej Tomaszewski; Ioanna Tzoulaki; Nicholette D Palmer; Thor Aspelund; Melissa Garcia; Yen-Pei C Chang; Jeffrey R O'Connell; Nanette I Steinle; Diederick E Grobbee; Dan E Arking; Sharon L Kardia; Alanna C Morrison; Dena Hernandez; Samer Najjar; Wendy L McArdle; David Hadley; Morris J Brown; John M Connell; Aroon D Hingorani; Ian N M Day; Debbie A Lawlor; John P Beilby; Robert W Lawrence; Robert Clarke; Jemma C Hopewell; Halit Ongen; Albert W Dreisbach; Yali Li; J Hunter Young; Joshua C Bis; Mika Kähönen; Jorma Viikari; Linda S Adair; Nanette R Lee; Ming-Huei Chen; Matthias Olden; Cristian Pattaro; Judith A Hoffman Bolton; Anna Köttgen; Sven Bergmann; Vincent Mooser; Nish Chaturvedi; Timothy M Frayling; Muhammad Islam; Tazeen H Jafar; Jeanette Erdmann; Smita R Kulkarni; Stefan R Bornstein; Jürgen Grässler; Leif Groop; Benjamin F Voight; Johannes Kettunen; Philip Howard; Andrew Taylor; Simonetta Guarrera; Fulvio Ricceri; Valur Emilsson; Andrew Plump; Inês Barroso; Kay-Tee Khaw; Alan B Weder; Steven C Hunt; Yan V Sun; Richard N Bergman; Francis S Collins; Lori L Bonnycastle; Laura J Scott; Heather M Stringham; Leena Peltonen; Markus Perola; Erkki Vartiainen; Stefan-Martin Brand; Jan A Staessen; Thomas J Wang; Paul R Burton; Maria Soler Artigas; Yanbin Dong; Harold Snieder; Xiaoling Wang; Haidong Zhu; Kurt K Lohman; Megan E Rudock; Susan R Heckbert; Nicholas L Smith; Kerri L Wiggins; Ayo Doumatey; Daniel Shriner; Gudrun Veldre; Margus Viigimaa; Sanjay Kinra; Dorairaj Prabhakaran; Vikal Tripathy; Carl D Langefeld; Annika Rosengren; Dag S Thelle; Anna Maria Corsi; Andrew Singleton; Terrence Forrester; Gina Hilton; Colin A McKenzie; Tunde Salako; Naoharu Iwai; Yoshikuni Kita; Toshio Ogihara; Takayoshi Ohkubo; Tomonori Okamura; Hirotsugu Ueshima; Satoshi Umemura; Susana Eyheramendy; Thomas Meitinger; H-Erich Wichmann; Yoon Shin Cho; Hyung-Lae Kim; Jong-Young Lee; James Scott; Joban S Sehmi; Weihua Zhang; Bo Hedblad; Peter Nilsson; George Davey Smith; Andrew Wong; Narisu Narisu; Alena Stančáková; Leslie J Raffel; Jie Yao; Sekar Kathiresan; Christopher J O'Donnell; Stephen M Schwartz; M Arfan Ikram; W T Longstreth; Thomas H Mosley; Sudha Seshadri; Nick R G Shrine; Louise V Wain; Mario A Morken; Amy J Swift; Jaana Laitinen; Inga Prokopenko; Paavo Zitting; Jackie A Cooper; Steve E Humphries; John Danesh; Asif Rasheed; Anuj Goel; Anders Hamsten; Hugh Watkins; Stephan J L Bakker; Wiek H van Gilst; Charles S Janipalli; K Radha Mani; Chittaranjan S Yajnik; Albert Hofman; Francesco U S Mattace-Raso; Ben A Oostra; Ayse Demirkan; Aaron Isaacs; Fernando Rivadeneira; Edward G Lakatta; Marco Orru; Angelo Scuteri; Mika Ala-Korpela; Antti J Kangas; Leo-Pekka Lyytikäinen; Pasi Soininen; Taru Tukiainen; Peter Würtz; Rick Twee-Hee Ong; Marcus Dörr; Heyo K Kroemer; Uwe Völker; Henry Völzke; Pilar Galan; Serge Hercberg; Mark Lathrop; Diana Zelenika; Panos Deloukas; Massimo Mangino; Tim D Spector; Guangju Zhai; James F Meschia; Michael A Nalls; Pankaj Sharma; Janos Terzic; M V Kranthi Kumar; Matthew Denniff; Ewa Zukowska-Szczechowska; Lynne E Wagenknecht; F Gerald R Fowkes; Fadi J Charchar; Peter E H Schwarz; Caroline Hayward; Xiuqing Guo; Charles Rotimi; Michiel L Bots; Eva Brand; Nilesh J Samani; Ozren Polasek; Philippa J Talmud; Fredrik Nyberg; Diana Kuh; Maris Laan; Kristian Hveem; Lyle J Palmer; Yvonne T van der Schouw; Juan P Casas; Karen L Mohlke; Paolo Vineis; Olli Raitakari; Santhi K Ganesh; Tien Y Wong; E Shyong Tai; Richard S Cooper; Markku Laakso; Dabeeru C Rao; Tamara B Harris; Richard W Morris; Anna F Dominiczak; Mika Kivimaki; Michael G Marmot; Tetsuro Miki; Danish Saleheen; Giriraj R Chandak; Josef Coresh; Gerjan Navis; Veikko Salomaa; Bok-Ghee Han; Xiaofeng Zhu; Jaspal S Kooner; Olle Melander; Paul M Ridker; Stefania Bandinelli; Ulf B Gyllensten; Alan F Wright; James F Wilson; Luigi Ferrucci; Martin Farrall; Jaakko Tuomilehto; Peter P Pramstaller; Roberto Elosua; Nicole Soranzo; Eric J G Sijbrands; David Altshuler; Ruth J F Loos; Alan R Shuldiner; Christian Gieger; Pierre Meneton; Andre G Uitterlinden; Nicholas J Wareham; Vilmundur Gudnason; Jerome I Rotter; Rainer Rettig; Manuela Uda; David P Strachan; Jacqueline C M Witteman; Anna-Liisa Hartikainen; Jacques S Beckmann; Eric Boerwinkle; Ramachandran S Vasan; Michael Boehnke; Martin G Larson; Marjo-Riitta Järvelin; Bruce M Psaty; Gonçalo R Abecasis; Aravinda Chakravarti; Paul Elliott; Cornelia M van Duijn; Christopher Newton-Cheh; Daniel Levy; Mark J Caulfield; Toby Johnson
Journal:  Nature       Date:  2011-09-11       Impact factor: 49.962

6.  Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Authors:  Helen R Warren; Evangelos Evangelou; Claudia P Cabrera; He Gao; Meixia Ren; Borbala Mifsud; Ioanna Ntalla; Praveen Surendran; Chunyu Liu; James P Cook; Aldi T Kraja; Fotios Drenos; Marie Loh; Niek Verweij; Jonathan Marten; Ibrahim Karaman; Marcelo P Segura Lepe; Paul F O'Reilly; Joanne Knight; Harold Snieder; Norihiro Kato; Jiang He; E Shyong Tai; M Abdullah Said; David Porteous; Maris Alver; Neil Poulter; Martin Farrall; Ron T Gansevoort; Sandosh Padmanabhan; Reedik Mägi; Alice Stanton; John Connell; Stephan J L Bakker; Andres Metspalu; Denis C Shields; Simon Thom; Morris Brown; Peter Sever; Tõnu Esko; Caroline Hayward; Pim van der Harst; Danish Saleheen; Rajiv Chowdhury; John C Chambers; Daniel I Chasman; Aravinda Chakravarti; Christopher Newton-Cheh; Cecilia M Lindgren; Daniel Levy; Jaspal S Kooner; Bernard Keavney; Maciej Tomaszewski; Nilesh J Samani; Joanna M M Howson; Martin D Tobin; Patricia B Munroe; Georg B Ehret; Louise V Wain
Journal:  Nat Genet       Date:  2017-01-30       Impact factor: 38.330

7.  Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Authors:  Ayush Giri; Jacklyn N Hellwege; Jacob M Keaton; Jihwan Park; Chengxiang Qiu; Helen R Warren; Eric S Torstenson; Csaba P Kovesdy; Yan V Sun; Otis D Wilson; Cassianne Robinson-Cohen; Christianne L Roumie; Cecilia P Chung; Kelly A Birdwell; Scott M Damrauer; Scott L DuVall; Derek Klarin; Kelly Cho; Yu Wang; Evangelos Evangelou; Claudia P Cabrera; Louise V Wain; Rojesh Shrestha; Brian S Mautz; Elvis A Akwo; Muralidharan Sargurupremraj; Stéphanie Debette; Michael Boehnke; Laura J Scott; Jian'an Luan; Jing-Hua Zhao; Sara M Willems; Sébastien Thériault; Nabi Shah; Christopher Oldmeadow; Peter Almgren; Ruifang Li-Gao; Niek Verweij; Thibaud S Boutin; Massimo Mangino; Ioanna Ntalla; Elena Feofanova; Praveen Surendran; James P Cook; Savita Karthikeyan; Najim Lahrouchi; Chunyu Liu; Nuno Sepúlveda; Tom G Richardson; Aldi Kraja; Philippe Amouyel; Martin Farrall; Neil R Poulter; Markku Laakso; Eleftheria Zeggini; Peter Sever; Robert A Scott; Claudia Langenberg; Nicholas J Wareham; David Conen; Colin Neil Alexander Palmer; John Attia; Daniel I Chasman; Paul M Ridker; Olle Melander; Dennis Owen Mook-Kanamori; Pim van der Harst; Francesco Cucca; David Schlessinger; Caroline Hayward; Tim D Spector; Marjo-Riitta Jarvelin; Branwen J Hennig; Nicholas J Timpson; Wei-Qi Wei; Joshua C Smith; Yaomin Xu; Michael E Matheny; Edward E Siew; Cecilia Lindgren; Karl-Heinz Herzig; George Dedoussis; Joshua C Denny; Bruce M Psaty; Joanna M M Howson; Patricia B Munroe; Christopher Newton-Cheh; Mark J Caulfield; Paul Elliott; J Michael Gaziano; John Concato; Peter W F Wilson; Philip S Tsao; Digna R Velez Edwards; Katalin Susztak; Christopher J O'Donnell; Adriana M Hung; Todd L Edwards
Journal:  Nat Genet       Date:  2018-12-21       Impact factor: 38.330

8.  Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Authors:  Evangelos Evangelou; Helen R Warren; David Mosen-Ansorena; Borbala Mifsud; Raha Pazoki; He Gao; Georgios Ntritsos; Niki Dimou; Claudia P Cabrera; Ibrahim Karaman; Fu Liang Ng; Marina Evangelou; Katarzyna Witkowska; Evan Tzanis; Jacklyn N Hellwege; Ayush Giri; Digna R Velez Edwards; Yan V Sun; Kelly Cho; J Michael Gaziano; Peter W F Wilson; Philip S Tsao; Csaba P Kovesdy; Tonu Esko; Reedik Mägi; Lili Milani; Peter Almgren; Thibaud Boutin; Stéphanie Debette; Jun Ding; Franco Giulianini; Elizabeth G Holliday; Anne U Jackson; Ruifang Li-Gao; Wei-Yu Lin; Jian'an Luan; Massimo Mangino; Christopher Oldmeadow; Bram Peter Prins; Yong Qian; Muralidharan Sargurupremraj; Nabi Shah; Praveen Surendran; Sébastien Thériault; Niek Verweij; Sara M Willems; Jing-Hua Zhao; Philippe Amouyel; John Connell; Renée de Mutsert; Alex S F Doney; Martin Farrall; Cristina Menni; Andrew D Morris; Raymond Noordam; Guillaume Paré; Neil R Poulter; Denis C Shields; Alice Stanton; Simon Thom; Gonçalo Abecasis; Najaf Amin; Dan E Arking; Kristin L Ayers; Caterina M Barbieri; Chiara Batini; Joshua C Bis; Tineka Blake; Murielle Bochud; Michael Boehnke; Eric Boerwinkle; Dorret I Boomsma; Erwin P Bottinger; Peter S Braund; Marco Brumat; Archie Campbell; Harry Campbell; Aravinda Chakravarti; John C Chambers; Ganesh Chauhan; Marina Ciullo; Massimiliano Cocca; Francis Collins; Heather J Cordell; Gail Davies; Martin H de Borst; Eco J de Geus; Ian J Deary; Joris Deelen; Fabiola Del Greco M; Cumhur Yusuf Demirkale; Marcus Dörr; Georg B Ehret; Roberto Elosua; Stefan Enroth; A Mesut Erzurumluoglu; Teresa Ferreira; Mattias Frånberg; Oscar H Franco; Ilaria Gandin; Paolo Gasparini; Vilmantas Giedraitis; Christian Gieger; Giorgia Girotto; Anuj Goel; Alan J Gow; Vilmundur Gudnason; Xiuqing Guo; Ulf Gyllensten; Anders Hamsten; Tamara B Harris; Sarah E Harris; Catharina A Hartman; Aki S Havulinna; Andrew A Hicks; Edith Hofer; Albert Hofman; Jouke-Jan Hottenga; Jennifer E Huffman; Shih-Jen Hwang; Erik Ingelsson; Alan James; Rick Jansen; Marjo-Riitta Jarvelin; Roby Joehanes; Åsa Johansson; Andrew D Johnson; Peter K Joshi; Pekka Jousilahti; J Wouter Jukema; Antti Jula; Mika Kähönen; Sekar Kathiresan; Bernard D Keavney; Kay-Tee Khaw; Paul Knekt; Joanne Knight; Ivana Kolcic; Jaspal S Kooner; Seppo Koskinen; Kati Kristiansson; Zoltan Kutalik; Maris Laan; Marty Larson; Lenore J Launer; Benjamin Lehne; Terho Lehtimäki; David C M Liewald; Li Lin; Lars Lind; Cecilia M Lindgren; YongMei Liu; Ruth J F Loos; Lorna M Lopez; Yingchang Lu; Leo-Pekka Lyytikäinen; Anubha Mahajan; Chrysovalanto Mamasoula; Jaume Marrugat; Jonathan Marten; Yuri Milaneschi; Anna Morgan; Andrew P Morris; Alanna C Morrison; Peter J Munson; Mike A Nalls; Priyanka Nandakumar; Christopher P Nelson; Teemu Niiranen; Ilja M Nolte; Teresa Nutile; Albertine J Oldehinkel; Ben A Oostra; Paul F O'Reilly; Elin Org; Sandosh Padmanabhan; Walter Palmas; Aarno Palotie; Alison Pattie; Brenda W J H Penninx; Markus Perola; Annette Peters; Ozren Polasek; Peter P Pramstaller; Quang Tri Nguyen; Olli T Raitakari; Meixia Ren; Rainer Rettig; Kenneth Rice; Paul M Ridker; Janina S Ried; Harriëtte Riese; Samuli Ripatti; Antonietta Robino; Lynda M Rose; Jerome I Rotter; Igor Rudan; Daniela Ruggiero; Yasaman Saba; Cinzia F Sala; Veikko Salomaa; Nilesh J Samani; Antti-Pekka Sarin; Reinhold Schmidt; Helena Schmidt; Nick Shrine; David Siscovick; Albert V Smith; Harold Snieder; Siim Sõber; Rossella Sorice; John M Starr; David J Stott; David P Strachan; Rona J Strawbridge; Johan Sundström; Morris A Swertz; Kent D Taylor; Alexander Teumer; Martin D Tobin; Maciej Tomaszewski; Daniela Toniolo; Michela Traglia; Stella Trompet; Jaakko Tuomilehto; Christophe Tzourio; André G Uitterlinden; Ahmad Vaez; Peter J van der Most; Cornelia M van Duijn; Anne-Claire Vergnaud; Germaine C Verwoert; Veronique Vitart; Uwe Völker; Peter Vollenweider; Dragana Vuckovic; Hugh Watkins; Sarah H Wild; Gonneke Willemsen; James F Wilson; Alan F Wright; Jie Yao; Tatijana Zemunik; Weihua Zhang; John R Attia; Adam S Butterworth; Daniel I Chasman; David Conen; Francesco Cucca; John Danesh; Caroline Hayward; Joanna M M Howson; Markku Laakso; Edward G Lakatta; Claudia Langenberg; Olle Melander; Dennis O Mook-Kanamori; Colin N A Palmer; Lorenz Risch; Robert A Scott; Rodney J Scott; Peter Sever; Tim D Spector; Pim van der Harst; Nicholas J Wareham; Eleftheria Zeggini; Daniel Levy; Patricia B Munroe; Christopher Newton-Cheh; Morris J Brown; Andres Metspalu; Adriana M Hung; Christopher J O'Donnell; Todd L Edwards; Bruce M Psaty; Ioanna Tzoulaki; Michael R Barnes; Louise V Wain; Paul Elliott; Mark J Caulfield
Journal:  Nat Genet       Date:  2018-09-17       Impact factor: 41.307

9.  Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Authors:  Praveen Surendran; Fotios Drenos; Robin Young; Helen Warren; James P Cook; Alisa K Manning; Niels Grarup; Xueling Sim; Danish Saleheen; Folkert W Asselbergs; Cecilia M Lindgren; John Danesh; Louise V Wain; Adam S Butterworth; Joanna Mm Howson; Patricia B Munroe; Daniel R Barnes; Kate Witkowska; James R Staley; Vinicius Tragante; Taru Tukiainen; Hanieh Yaghootkar; Nicholas Masca; Daniel F Freitag; Teresa Ferreira; Olga Giannakopoulou; Andrew Tinker; Magdalena Harakalova; Evelin Mihailov; Chunyu Liu; Aldi T Kraja; Sune Fallgaard Nielsen; Asif Rasheed; Maria Samuel; Wei Zhao; Lori L Bonnycastle; Anne U Jackson; Narisu Narisu; Amy J Swift; Lorraine Southam; Jonathan Marten; Jeroen R Huyghe; Alena Stančáková; Cristiano Fava; Therese Ohlsson; Angela Matchan; Kathleen E Stirrups; Jette Bork-Jensen; Anette P Gjesing; Jukka Kontto; Markus Perola; Susan Shaw-Hawkins; Aki S Havulinna; He Zhang; Louise A Donnelly; Christopher J Groves; N William Rayner; Matt J Neville; Neil R Robertson; Andrianos M Yiorkas; Karl-Heinz Herzig; Eero Kajantie; Weihua Zhang; Sara M Willems; Lars Lannfelt; Giovanni Malerba; Nicole Soranzo; Elisabetta Trabetti; Niek Verweij; Evangelos Evangelou; Alireza Moayyeri; Anne-Claire Vergnaud; Christopher P Nelson; Alaitz Poveda; Tibor V Varga; Muriel Caslake; Anton Jm de Craen; Stella Trompet; Jian'an Luan; Robert A Scott; Sarah E Harris; David Cm Liewald; Riccardo Marioni; Cristina Menni; Aliki-Eleni Farmaki; Göran Hallmans; Frida Renström; Jennifer E Huffman; Maija Hassinen; Stephen Burgess; Ramachandran S Vasan; Janine F Felix; Maria Uria-Nickelsen; Anders Malarstig; Dermot F Reily; Maarten Hoek; Thomas Vogt; Honghuang Lin; Wolfgang Lieb; Matthew Traylor; Hugh F Markus; Heather M Highland; Anne E Justice; Eirini Marouli; Jaana Lindström; Matti Uusitupa; Pirjo Komulainen; Timo A Lakka; Rainer Rauramaa; Ozren Polasek; Igor Rudan; Olov Rolandsson; Paul W Franks; George Dedoussis; Timothy D Spector; Pekka Jousilahti; Satu Männistö; Ian J Deary; John M Starr; Claudia Langenberg; Nick J Wareham; Morris J Brown; Anna F Dominiczak; John M Connell; J Wouter Jukema; Naveed Sattar; Ian Ford; Chris J Packard; Tõnu Esko; Reedik Mägi; Andres Metspalu; Rudolf A de Boer; Peter van der Meer; Pim van der Harst; Giovanni Gambaro; Erik Ingelsson; Lars Lind; Paul Iw de Bakker; Mattijs E Numans; Ivan Brandslund; Cramer Christensen; Eva Rb Petersen; Eeva Korpi-Hyövälti; Heikki Oksa; John C Chambers; Jaspal S Kooner; Alexandra If Blakemore; Steve Franks; Marjo-Riitta Jarvelin; Lise L Husemoen; Allan Linneberg; Tea Skaaby; Betina Thuesen; Fredrik Karpe; Jaakko Tuomilehto; Alex Sf Doney; Andrew D Morris; Colin Na Palmer; Oddgeir Lingaas Holmen; Kristian Hveem; Cristen J Willer; Tiinamaija Tuomi; Leif Groop; AnneMari Käräjämäki; Aarno Palotie; Samuli Ripatti; Veikko Salomaa; Dewan S Alam; Abdulla Al Shafi Majumder; Emanuele Di Angelantonio; Rajiv Chowdhury; Mark I McCarthy; Neil Poulter; Alice V Stanton; Peter Sever; Philippe Amouyel; Dominique Arveiler; Stefan Blankenberg; Jean Ferrières; Frank Kee; Kari Kuulasmaa; Martina Müller-Nurasyid; Giovanni Veronesi; Jarmo Virtamo; Panos Deloukas; Paul Elliott; Eleftheria Zeggini; Sekar Kathiresan; Olle Melander; Johanna Kuusisto; Markku Laakso; Sandosh Padmanabhan; David Porteous; Caroline Hayward; Generation Scotland; Francis S Collins; Karen L Mohlke; Torben Hansen; Oluf Pedersen; Michael Boehnke; Heather M Stringham; Philippe Frossard; Christopher Newton-Cheh; Martin D Tobin; Børge Grønne Nordestgaard; Mark J Caulfield; Anubha Mahajan; Andrew P Morris; Maciej Tomaszewski; Nilesh J Samani
Journal:  Nat Genet       Date:  2016-09-12       Impact factor: 38.330

10.  The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Authors:  Georg B Ehret; Teresa Ferreira; Daniel I Chasman; Anne U Jackson; Ellen M Schmidt; Toby Johnson; Gudmar Thorleifsson; Jian'an Luan; Lousie A Donnelly; Stavroula Kanoni; Ann-Kristin Petersen; Vasyl Pihur; Rona J Strawbridge; Dmitry Shungin; Maria F Hughes; Osorio Meirelles; Marika Kaakinen; Nabila Bouatia-Naji; Kati Kristiansson; Sonia Shah; Marcus E Kleber; Xiuqing Guo; Leo-Pekka Lyytikäinen; Cristiano Fava; Niclas Eriksson; Ilja M Nolte; Patrik K Magnusson; Elias L Salfati; Loukianos S Rallidis; Elizabeth Theusch; Andrew J P Smith; Lasse Folkersen; Kate Witkowska; Tune H Pers; Roby Joehanes; Stuart K Kim; Lazaros Lataniotis; Rick Jansen; Andrew D Johnson; Helen Warren; Young Jin Kim; Wei Zhao; Ying Wu; Bamidele O Tayo; Murielle Bochud; Devin Absher; Linda S Adair; Najaf Amin; Dan E Arking; Tomas Axelsson; Damiano Baldassarre; Beverley Balkau; Stefania Bandinelli; Michael R Barnes; Inês Barroso; Stephen Bevan; Joshua C Bis; Gyda Bjornsdottir; Michael Boehnke; Eric Boerwinkle; Lori L Bonnycastle; Dorret I Boomsma; Stefan R Bornstein; Morris J Brown; Michel Burnier; Claudia P Cabrera; John C Chambers; I-Shou Chang; Ching-Yu Cheng; Peter S Chines; Ren-Hua Chung; Francis S Collins; John M Connell; Angela Döring; Jean Dallongeville; John Danesh; Ulf de Faire; Graciela Delgado; Anna F Dominiczak; Alex S F Doney; Fotios Drenos; Sarah Edkins; John D Eicher; Roberto Elosua; Stefan Enroth; Jeanette Erdmann; Per Eriksson; Tonu Esko; Evangelos Evangelou; Alun Evans; Tove Fall; Martin Farrall; Janine F Felix; Jean Ferrières; Luigi Ferrucci; Myriam Fornage; Terrence Forrester; Nora Franceschini; Oscar H Franco Duran; Anders Franco-Cereceda; Ross M Fraser; Santhi K Ganesh; He Gao; Karl Gertow; Francesco Gianfagna; Bruna Gigante; Franco Giulianini; Anuj Goel; Alison H Goodall; Mark O Goodarzi; Mathias Gorski; Jürgen Gräßler; Christopher Groves; Vilmundur Gudnason; Ulf Gyllensten; Göran Hallmans; Anna-Liisa Hartikainen; Maija Hassinen; Aki S Havulinna; Caroline Hayward; Serge Hercberg; Karl-Heinz Herzig; Andrew A Hicks; Aroon D Hingorani; Joel N Hirschhorn; Albert Hofman; Jostein Holmen; Oddgeir Lingaas Holmen; Jouke-Jan Hottenga; Phil Howard; Chao A Hsiung; Steven C Hunt; M Arfan Ikram; Thomas Illig; Carlos Iribarren; Richard A Jensen; Mika Kähönen; Hyun Kang; Sekar Kathiresan; Brendan J Keating; Kay-Tee Khaw; Yun Kyoung Kim; Eric Kim; Mika Kivimaki; Norman Klopp; Genovefa Kolovou; Pirjo Komulainen; Jaspal S Kooner; Gulum Kosova; Ronald M Krauss; Diana Kuh; Zoltan Kutalik; Johanna Kuusisto; Kirsti Kvaløy; Timo A Lakka; Nanette R Lee; I-Te Lee; Wen-Jane Lee; Daniel Levy; Xiaohui Li; Kae-Woei Liang; Honghuang Lin; Li Lin; Jaana Lindström; Stéphane Lobbens; Satu Männistö; Gabriele Müller; Martina Müller-Nurasyid; François Mach; Hugh S Markus; Eirini Marouli; Mark I McCarthy; Colin A McKenzie; Pierre Meneton; Cristina Menni; Andres Metspalu; Vladan Mijatovic; Leena Moilanen; May E Montasser; Andrew D Morris; Alanna C Morrison; Antonella Mulas; Ramaiah Nagaraja; Narisu Narisu; Kjell Nikus; Christopher J O'Donnell; Paul F O'Reilly; Ken K Ong; Fred Paccaud; Cameron D Palmer; Afshin Parsa; Nancy L Pedersen; Brenda W Penninx; Markus Perola; Annette Peters; Neil Poulter; Peter P Pramstaller; Bruce M Psaty; Thomas Quertermous; Dabeeru C Rao; Asif Rasheed; N William N W R Rayner; Frida Renström; Rainer Rettig; Kenneth M Rice; Robert Roberts; Lynda M Rose; Jacques Rossouw; Nilesh J Samani; Serena Sanna; Jouko Saramies; Heribert Schunkert; Sylvain Sebert; Wayne H-H Sheu; Young-Ah Shin; Xueling Sim; Johannes H Smit; Albert V Smith; Maria X Sosa; Tim D Spector; Alena Stančáková; Alice Stanton; Kathleen E Stirrups; Heather M Stringham; Johan Sundstrom; Amy J Swift; Ann-Christine Syvänen; E-Shyong Tai; Toshiko Tanaka; Kirill V Tarasov; Alexander Teumer; Unnur Thorsteinsdottir; Martin D Tobin; Elena Tremoli; Andre G Uitterlinden; Matti Uusitupa; Ahmad Vaez; Dhananjay Vaidya; Cornelia M van Duijn; Erik P A van Iperen; Ramachandran S Vasan; Germaine C Verwoert; Jarmo Virtamo; Veronique Vitart; Benjamin F Voight; Peter Vollenweider; Aline Wagner; Louise V Wain; Nicholas J Wareham; Hugh Watkins; Alan B Weder; Harm-Jan Westra; Rainford Wilks; Tom Wilsgaard; James F Wilson; Tien Y Wong; Tsun-Po Yang; Jie Yao; Loic Yengo; Weihua Zhang; Jing Hua Zhao; Xiaofeng Zhu; Pascal Bovet; Richard S Cooper; Karen L Mohlke; Danish Saleheen; Jong-Young Lee; Paul Elliott; Hinco J Gierman; Cristen J Willer; Lude Franke; G Kees Hovingh; Kent D Taylor; George Dedoussis; Peter Sever; Andrew Wong; Lars Lind; Themistocles L Assimes; Inger Njølstad; Peter Eh Schwarz; Claudia Langenberg; Harold Snieder; Mark J Caulfield; Olle Melander; Markku Laakso; Juha Saltevo; Rainer Rauramaa; Jaakko Tuomilehto; Erik Ingelsson; Terho Lehtimäki; Kristian Hveem; Walter Palmas; Winfried März; Meena Kumari; Veikko Salomaa; Yii-Der I Chen; Jerome I Rotter; Philippe Froguel; Marjo-Riitta Jarvelin; Edward G Lakatta; Kari Kuulasmaa; Paul W Franks; Anders Hamsten; H-Erich Wichmann; Colin N A Palmer; Kari Stefansson; Paul M Ridker; Ruth J F Loos; Aravinda Chakravarti; Panos Deloukas; Andrew P Morris; Christopher Newton-Cheh; Patricia B Munroe
Journal:  Nat Genet       Date:  2016-09-12       Impact factor: 38.330
View more
  7 in total

1.  Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.

Authors:  Hongbo Liu; Tomohito Doke; Dong Guo; Xin Sheng; Ziyuan Ma; Joseph Park; Ha My T Vy; Girish N Nadkarni; Amin Abedini; Zhen Miao; Matthew Palmer; Benjamin F Voight; Hongzhe Li; Christopher D Brown; Marylyn D Ritchie; Yan Shu; Katalin Susztak
Journal:  Nat Genet       Date:  2022-06-16       Impact factor: 41.307

Review 2.  Mendelian Randomization Analysis as a Tool to Gain Insights into Causes of Diseases: A Primer.

Authors:  Adrienne Tin; Anna Köttgen
Journal:  J Am Soc Nephrol       Date:  2021-06-16       Impact factor: 14.978

3.  Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension.

Authors:  Patrick Wu; QiPing Feng; Vern Eric Kerchberger; Scott D Nelson; Qingxia Chen; Bingshan Li; Todd L Edwards; Nancy J Cox; Elizabeth J Phillips; C Michael Stein; Dan M Roden; Joshua C Denny; Wei-Qi Wei
Journal:  Nat Commun       Date:  2022-01-10       Impact factor: 17.694

4.  Large-Scale Multi-Omics Studies Provide New Insights into Blood Pressure Regulation.

Authors:  Zoha Kamali; Jacob M Keaton; Shaghayegh Haghjooy Javanmard; Todd L Edwards; Harold Snieder; Ahmad Vaez
Journal:  Int J Mol Sci       Date:  2022-07-08       Impact factor: 6.208

5.  A Formative Study of the Implementation of Whole Genome Sequencing in Northern Ireland.

Authors:  Katie Kerr; Caoimhe McKenna; Shirley Heggarty; Caitlin Bailie; Julie McMullan; Ashleen Crowe; Jill Kilner; Michael Donnelly; Saralynne Boyle; Gillian Rea; Cheryl Flanagan; Shane McKee; Amy Jayne McKnight
Journal:  Genes (Basel)       Date:  2022-06-21       Impact factor: 4.141

6.  Breast cancer chemotherapy induces vascular dysfunction and hypertension through a NOX4-dependent mechanism.

Authors:  Piotr Szczepaniak; Mateusz Siedlinski; Diana Hodorowicz-Zaniewska; Ryszard Nosalski; Tomasz P Mikolajczyk; Aneta M Dobosz; Anna Dikalova; Sergey Dikalov; Joanna Streb; Katarzyna Gara; Pawel Basta; Jaroslaw Krolczyk; Joanna Sulicka-Grodzicka; Ewelina Jozefczuk; Anna Dziewulska; Blessy Saju; Iwona Laksa; Wei Chen; John Dormer; Maciej Tomaszewski; Pasquale Maffia; Marta Czesnikiewicz-Guzik; Filippo Crea; Agnieszka Dobrzyn; Javid Moslehi; Tomasz Grodzicki; David G Harrison; Tomasz J Guzik
Journal:  J Clin Invest       Date:  2022-07-01       Impact factor: 19.456

Review 7.  A review of causal discovery methods for molecular network analysis.

Authors:  Jack Kelly; Carlo Berzuini; Bernard Keavney; Maciej Tomaszewski; Hui Guo
Journal:  Mol Genet Genomic Med       Date:  2022-09-10       Impact factor: 2.473
  7 in total

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