| Literature DB >> 30224653 |
Evangelos Evangelou1,2, Helen R Warren3,4, David Mosen-Ansorena1, Borbala Mifsud3, Raha Pazoki1, He Gao1,5, Georgios Ntritsos2, Niki Dimou2, Claudia P Cabrera3,4, Ibrahim Karaman1, Fu Liang Ng3, Marina Evangelou1,6, Katarzyna Witkowska3, Evan Tzanis3, Jacklyn N Hellwege7, Ayush Giri8, Digna R Velez Edwards8, Yan V Sun9,10, Kelly Cho11,12, J Michael Gaziano11,12, Peter W F Wilson13, Philip S Tsao14, Csaba P Kovesdy15, Tonu Esko16,17, Reedik Mägi16, Lili Milani16, Peter Almgren18, Thibaud Boutin19, Stéphanie Debette20,21, Jun Ding22, Franco Giulianini23, Elizabeth G Holliday24, Anne U Jackson25, Ruifang Li-Gao26, Wei-Yu Lin27, Jian'an Luan28, Massimo Mangino29,30, Christopher Oldmeadow24, Bram Peter Prins31, Yong Qian22, Muralidharan Sargurupremraj21, Nabi Shah32,33, Praveen Surendran27, Sébastien Thériault34,35, Niek Verweij17,36,37, Sara M Willems28, Jing-Hua Zhao28, Philippe Amouyel38, John Connell39, Renée de Mutsert26, Alex S F Doney32, Martin Farrall40,41, Cristina Menni29, Andrew D Morris42, Raymond Noordam43, Guillaume Paré34, Neil R Poulter44, Denis C Shields45, Alice Stanton46, Simon Thom47, Gonçalo Abecasis48, Najaf Amin49, Dan E Arking50, Kristin L Ayers51,52, Caterina M Barbieri53, Chiara Batini54, Joshua C Bis55, Tineka Blake54, Murielle Bochud56, Michael Boehnke25, Eric Boerwinkle57, Dorret I Boomsma58, Erwin P Bottinger59, Peter S Braund60,61, Marco Brumat62, Archie Campbell63,64, Harry Campbell65, Aravinda Chakravarti50, John C Chambers1,5,66,67,68, Ganesh Chauhan69, Marina Ciullo70,71, Massimiliano Cocca72, Francis Collins73, Heather J Cordell51, Gail Davies74,75, Martin H de Borst76, Eco J de Geus58, Ian J Deary74,75, Joris Deelen77, Fabiola Del Greco M78, Cumhur Yusuf Demirkale79, Marcus Dörr80,81, Georg B Ehret50,82, Roberto Elosua83,84, Stefan Enroth85, A Mesut Erzurumluoglu54, Teresa Ferreira86,87, Mattias Frånberg88,89,90, Oscar H Franco91, Ilaria Gandin62, Paolo Gasparini62,72, Vilmantas Giedraitis92, Christian Gieger93,94,95, Giorgia Girotto62,72, Anuj Goel40,41, Alan J Gow74,96, Vilmundur Gudnason97,98, Xiuqing Guo99, Ulf Gyllensten85, Anders Hamsten88,89, Tamara B Harris100, Sarah E Harris63,74, Catharina A Hartman101, Aki S Havulinna102,103, Andrew A Hicks78, Edith Hofer104,105, Albert Hofman91,106, Jouke-Jan Hottenga58, Jennifer E Huffman19,107,108, Shih-Jen Hwang107,108, Erik Ingelsson109,110, Alan James111,112, Rick Jansen113, Marjo-Riitta Jarvelin1,5,114,115,116, Roby Joehanes107,117, Åsa Johansson85, Andrew D Johnson107,118, Peter K Joshi65, Pekka Jousilahti102, J Wouter Jukema119, Antti Jula102, Mika Kähönen120,121, Sekar Kathiresan17,36,122, Bernard D Keavney123,124, Kay-Tee Khaw125, Paul Knekt102, Joanne Knight126, Ivana Kolcic127, Jaspal S Kooner5,67,68,128, Seppo Koskinen102, Kati Kristiansson102, Zoltan Kutalik56,129, Maris Laan130, Marty Larson107, Lenore J Launer100, Benjamin Lehne1, Terho Lehtimäki131,132, David C M Liewald74,75, Li Lin82, Lars Lind133, Cecilia M Lindgren40,87,134, YongMei Liu135, Ruth J F Loos28,59,136, Lorna M Lopez74,137,138, Yingchang Lu59, Leo-Pekka Lyytikäinen131,132, Anubha Mahajan40, Chrysovalanto Mamasoula139, Jaume Marrugat83, Jonathan Marten19, Yuri Milaneschi140, Anna Morgan62, Andrew P Morris40,141, Alanna C Morrison142, Peter J Munson79, Mike A Nalls143,144, Priyanka Nandakumar50, Christopher P Nelson60,61, Teemu Niiranen102,145, Ilja M Nolte146, Teresa Nutile70, Albertine J Oldehinkel147, Ben A Oostra49, Paul F O'Reilly148, Elin Org16, Sandosh Padmanabhan64,149, Walter Palmas150, Aarno Palotie103,151,152, Alison Pattie75, Brenda W J H Penninx140, Markus Perola102,103,153, Annette Peters94,95,154, Ozren Polasek127,155, Peter P Pramstaller78,156,157, Quang Tri Nguyen79, Olli T Raitakari158,159, Meixia Ren160, Rainer Rettig161, Kenneth Rice162, Paul M Ridker23,163, Janina S Ried94, Harriëtte Riese147, Samuli Ripatti103,164, Antonietta Robino72, Lynda M Rose23, Jerome I Rotter99, Igor Rudan65, Daniela Ruggiero70,71, Yasaman Saba165, Cinzia F Sala53, Veikko Salomaa102, Nilesh J Samani60,61, Antti-Pekka Sarin103, Reinhold Schmidt104, Helena Schmidt165, Nick Shrine54, David Siscovick166, Albert V Smith97,98, Harold Snieder146, Siim Sõber130, Rossella Sorice70, John M Starr74,167, David J Stott168, David P Strachan169, Rona J Strawbridge88,89, Johan Sundström133, Morris A Swertz170, Kent D Taylor99, Alexander Teumer81,171, Martin D Tobin54, Maciej Tomaszewski123,124, Daniela Toniolo53, Michela Traglia53, Stella Trompet119,172, Jaakko Tuomilehto173,174,175,176, Christophe Tzourio21, André G Uitterlinden91,177, Ahmad Vaez146,178, Peter J van der Most146, Cornelia M van Duijn49, Anne-Claire Vergnaud1, Germaine C Verwoert91, Veronique Vitart19, Uwe Völker81,179, Peter Vollenweider180, Dragana Vuckovic62,181, Hugh Watkins40,41, Sarah H Wild182, Gonneke Willemsen58, James F Wilson19,65, Alan F Wright19, Jie Yao99, Tatijana Zemunik183, Weihua Zhang1,67, John R Attia24, Adam S Butterworth27,184, Daniel I Chasman23,163, David Conen185,186, Francesco Cucca187,188, John Danesh27,184, Caroline Hayward19, Joanna M M Howson27, Markku Laakso189, Edward G Lakatta190, Claudia Langenberg28, Olle Melander18, Dennis O Mook-Kanamori26,191, Colin N A Palmer32, Lorenz Risch192,193,194, Robert A Scott28, Rodney J Scott24, Peter Sever128, Tim D Spector29, Pim van der Harst195, Nicholas J Wareham28, Eleftheria Zeggini31, Daniel Levy107,118, Patricia B Munroe3,4, Christopher Newton-Cheh134,196,197, Morris J Brown3,4, Andres Metspalu16, Adriana M Hung198, Christopher J O'Donnell199, Todd L Edwards7, Bruce M Psaty200,201, Ioanna Tzoulaki1,2,5, Michael R Barnes3,4, Louise V Wain54,61, Paul Elliott202,203,204,205,206, Mark J Caulfield207,208.
Abstract
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.Entities:
Mesh：
Year: 2018 PMID： 30224653 PMCID： PMC6284793 DOI： 10.1038/s41588-018-0205-x
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307