Francisco Javier Candel1,2, Pablo Barreiro3,2, Jesús San Román4,2, María Del Mar Carretero2, Juan Carlos Sanz2, Marta Pérez-Abeledo2, Belén Ramos2, José Manuel Viñuela-Prieto5, Jesús Canora6, Francisco Javier Martínez-Peromingo7, Raquel Barba8, Antonio Zapatero9. 1. Clinical Microbiology and Infectious Diseases, IdISSC and IML Health Institutes, Hospital Universitario San Carlos, Madrid, Spain. 2. Regional Public Health Laboratory, Community of Madrid, Spain. 3. Infectious Diseases, Internal Medicine, Hospital General Universitario La Paz, Madrid, Spain. 4. Department of Medical Specialties and Public Health, Rey Juan Carlos University, Madrid, Spain. 5. Department of Neurosurgery, Hospital General Universitario La Paz, Madrid, Spain. 6. Assistant to the Vice-counselor of Public Health, Community of Madrid, Spain. 7. Director of Social and Health Coordination, Community of Madrid, Spain. 8. Medical Manager, Hospital Universitario Rey Juan Carlos, Madrid, Spain. 9. Vice-counselor of Public Health, Community of Madrid, Spain.
Abstract
BACKGROUND: Nursing homes for older adults have concentrated large numbers of severe cases and deaths for coronavirus disease 2019 (COVID-19). METHODS: Point seroprevalence study of nursing homes to describe the demography and characteristic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG)-positive residents and staff. RESULTS: Clinical information and blood samples were available for 9,332 residents (mean age 86.7 ± 8.1 years, 76.4% women) and 10,614 staff (mean age 45.6 ± 11.5, 86.2% women). Up to 84.4% of residents had frailty, 84.9% co-morbidity and 69.3% cognitive impairment; 65.2% of workers were health-aides.COVID-19 seroprevalence was 55.4% (95% confidence interval (CI), 54.4-56.4) for older adults and 31.5% (30.6-32.4) for staff. In multivariable analysis, frailty of residents was related with seropositivity (odds ratio (OR): 1.19, P = 0.02). In the case of staff, age > 50 years (2.10, P < 0.001), obesity (1.19, P = 0.01), being a health-aide (1.94, P < 0.001), working in a center with high seroprevalence in residents (3.49, P < 0.001) and contact with external cases of COVID-19 (1.52, P < 0.001) were factors associated with seropositivity. Past symptoms of COVID-19 were good predictors of seropositivity for residents (5.41, P < 0.001) and staff (2.52, P < 0.001). CONCLUSIONS: Level of dependency influences risk of COVID-19 among residents. Individual and work factors, contacts outside the nursing home are associated with COVID-19 exposure in staff members. It is key to strengthen control measures to prevent the introduction of COVID-19 into care facilities from the community.
BACKGROUND: Nursing homes for older adults have concentrated large numbers of severe cases and deaths for coronavirus disease 2019 (COVID-19). METHODS: Point seroprevalence study of nursing homes to describe the demography and characteristic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG)-positive residents and staff. RESULTS: Clinical information and blood samples were available for 9,332 residents (mean age 86.7 ± 8.1 years, 76.4% women) and 10,614 staff (mean age 45.6 ± 11.5, 86.2% women). Up to 84.4% of residents had frailty, 84.9% co-morbidity and 69.3% cognitive impairment; 65.2% of workers were health-aides.COVID-19 seroprevalence was 55.4% (95% confidence interval (CI), 54.4-56.4) for older adults and 31.5% (30.6-32.4) for staff. In multivariable analysis, frailty of residents was related with seropositivity (odds ratio (OR): 1.19, P = 0.02). In the case of staff, age > 50 years (2.10, P < 0.001), obesity (1.19, P = 0.01), being a health-aide (1.94, P < 0.001), working in a center with high seroprevalence in residents (3.49, P < 0.001) and contact with external cases of COVID-19 (1.52, P < 0.001) were factors associated with seropositivity. Past symptoms of COVID-19 were good predictors of seropositivity for residents (5.41, P < 0.001) and staff (2.52, P < 0.001). CONCLUSIONS: Level of dependency influences risk of COVID-19 among residents. Individual and work factors, contacts outside the nursing home are associated with COVID-19 exposure in staff members. It is key to strengthen control measures to prevent the introduction of COVID-19 into care facilities from the community.
Authors: Stephen M Friedman; Amy L Davidow; Manisha Gurumurthy; Reza Peymani; John Webb; Keya Desai; Richard Siderits; Anna Nepomich; Edward Lifshitz; Pauline A Thomas Journal: J Community Health Date: 2022-06-15
Authors: F J Candel; P Barreiro; J San-Román; J C Sanz-Moreno; M M Carretero; F J Martínez-Peromingo; R Barba; A Lastra; J Vázquez; F Prados; J Canora; A Zapatero Journal: Rev Esp Quimioter Date: 2021-09-30 Impact factor: 1.553
Authors: Jesús San Román; Francisco J Candel; María Del Mar Carretero; Juan Carlos Sanz; Marta Pérez-Abeledo; Pablo Barreiro; José Manuel Viñuela-Prieto; Belén Ramos; Jesús Canora; Raquel Barba; Antonio Zapatero; Francisco Javier Martínez-Peromingo Journal: Gerontology Date: 2022-06-02 Impact factor: 5.597
Authors: Jesús San Román; Francisco Javier Candel; Juan Carlos Sanz; Paloma López; Rocío Menéndez-Colino; Pablo Barreiro; María Del Mar Carretero; Marta Pérez-Abeledo; José Manuel Viñuela-Prieto; Belén Ramos; Jesús Canora; Raquel Barba; Antonio Zapatero-Gaviria; Franciso Javier Martínez-Peromingo Journal: Vaccines (Basel) Date: 2022-03-02