| Literature DB >> 33923111 |
Domenico Nuzzo1,2, Pasquale Picone1,2, Costanza Giardina3, Miriana Scordino3, Giuseppa Mudò3, Mario Pagliaro4, Antonino Scurria4, Francesco Meneguzzo5, Laura M Ilharco6, Alexandra Fidalgo6, Rosa Alduina2, Alessandro Presentato2, Rosaria Ciriminna4, Valentina Di Liberto3.
Abstract
Lemon IntegroPectin obtained via hydrodynamic cavitation of organic lemon processing waste in water shows significant neuroprotective activity in vitro, as first reported in this study investigating the effects of both lemon IntegroPectin and commercial citrus pectin on cell viability, cell morphology, reactive oxygen species (ROS) production, and mitochondria perturbation induced by treatment of neuronal SH-SY5Y human cells with H2O2. Mediated by ROS, including H2O2 and its derivatives, oxidative stress alters numerous cellular processes, such as mitochondrial regulation and cell signaling, propagating cellular injury that leads to incurable neurodegenerative diseases. These results, and the absence of toxicity of this new pectic substance rich in adsorbed flavonoids and terpenes, suggest further studies to investigate its activity in preventing, retarding, or even curing neurological diseases.Entities:
Keywords: antioxidant; flavonoids; hesperidin; mitochondria; neurological disease; neuroprotective; oxidative stress; pectin
Year: 2021 PMID： 33923111 DOI： 10.3390/antiox10050669
Source DB: PubMed Journal: Antioxidants (Basel) ISSN： 2076-3921