Clinton Hall1, Johnni Hansen2, Jørn Olsen1,3, Di He1, Ondine S von Ehrenstein1,4, Beate Ritz1, Julia E Heck5,6. 1. Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA. 2. Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark. 3. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. 4. Department of Community Health Sciences, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA. 5. Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA. julia.heck@unt.edu. 6. College of Health and Public Service, University of North Texas, Denton, TX, USA. julia.heck@unt.edu.
Abstract
PURPOSE: To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). METHODS: This population-based case-control study included childhood GCT cases in Denmark diagnosed 1968-2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs). RESULTS: Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23-4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94-14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30-4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77-2.95). CONCLUSION: Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors.
PURPOSE: To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). METHODS: This population-based case-control study included childhood GCT cases in Denmark diagnosed 1968-2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs). RESULTS: Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23-4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94-14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30-4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77-2.95). CONCLUSION: Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors.
Authors: Zhi Chen; Leslie Robison; Roger Giller; Mark Krailo; Mary Davis; Stella Davies; Xiao-Ou Shu Journal: Int J Hyg Environ Health Date: 2005-09-19 Impact factor: 5.840
Authors: Clinton Hall; Johnni Hansen; Ondine S von Ehrenstein; Di He; Jørn Olsen; Beate Ritz; Julia E Heck Journal: Int Arch Occup Environ Health Date: 2020-02-05 Impact factor: 3.015
Authors: Zhi Chen; Patricia A Stewart; Stella Davies; Roger Giller; Mark Krailo; Mary Davis; Leslie Robison; Xiao-Ou Shu Journal: Am J Epidemiol Date: 2005-09-28 Impact factor: 4.897
Authors: Clinton Hall; Julia E Heck; Beate Ritz; Myles Cockburn; Loraine A Escobedo; Ondine S von Ehrenstein Journal: J Occup Environ Med Date: 2019-06 Impact factor: 2.306
Authors: Julia E Heck; Jun Wu; Christina Lombardi; Jiaheng Qiu; Travis J Meyers; Michelle Wilhelm; Myles Cockburn; Beate Ritz Journal: Environ Health Perspect Date: 2013-09-10 Impact factor: 9.031
Authors: Andrew S Park; Beate Ritz; Chenxiao Ling; Myles Cockburn; Julia E Heck Journal: Int J Hyg Environ Health Date: 2017-06-24 Impact factor: 7.401
Authors: Shukrullah Ahmadi; Margot Guth; Astrid Coste; Liacine Bouaoun; Aurélie Danjou; Marie Lefevre; Brigitte Dananché; Delphine Praud; Martie Van Tongeren; Louis Bujan; Olivia Pérol; Joachim Schüz; Barbara Charbotel; Béatrice Fervers; Ann Olsson Journal: Cancers (Basel) Date: 2022-10-10 Impact factor: 6.575