Clinton Hall1, Julia E Heck, Beate Ritz, Myles Cockburn, Loraine A Escobedo, Ondine S von Ehrenstein. 1. Department of Epidemiology, University of California, Los Angeles Fielding School of Public Health, Los Angeles, California (Dr Hall, Dr von Ehrenstein, Dr Ritz, Dr Heck); Department of Environmental Health Sciences, University of California, Los Angeles Fielding School of Public Health, Los Angeles, California (Dr Ritz); Department of Community Health Sciences, University of California, Los Angeles, Fielding School of Public Health, Los Angeles, California (Dr von Ehrenstein); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (Dr Cockburn); Spatial Sciences Institute, Dornsife College of Arts, Letters and Sciences, University of Southern California, Los Angeles, California (Dr Escobedo); Leidos, Inc., San Diego, California (Dr Hall).
Abstract
OBJECTIVE: To assess prenatal air toxics exposure and risk for childhood germ cell tumors (GCTs) by histological subtype (yolk sac tumor and teratoma). METHODS: In this case-control study, GCT cases less than 6 years (n = 243) identified from California Cancer Registry records were matched by birth year to cancer-free population controls (n = 147,100), 1984 to 2013. Routinely monitored air toxic exposures were linked to subjects' birth address. Logistic regression estimated GCT risks per interquartile range increase in exposure. RESULTS: Prenatal exposure to various highly-correlated, traffic-related air toxics during the second trimester increased GCT risk, particularly 1,3-butadiene (odds ratio [OR] = 1.51; 95% confidence interval [CI] = 1.01, 2.26) and meta/para-xylene (OR = 1.56; 95% CI = 1.10, 2.21). Analyses by subtype indicated elevated ORs for yolk sac tumors but not teratomas. CONCLUSION: Our estimated ORs are consistent with positive associations between some prenatal traffic-related air toxics and GCT risk, notably yolk sac tumors.
OBJECTIVE: To assess prenatal air toxics exposure and risk for childhood germ cell tumors (GCTs) by histological subtype (yolk sac tumor and teratoma). METHODS: In this case-control study, GCT cases less than 6 years (n = 243) identified from California Cancer Registry records were matched by birth year to cancer-free population controls (n = 147,100), 1984 to 2013. Routinely monitored air toxic exposures were linked to subjects' birth address. Logistic regression estimated GCT risks per interquartile range increase in exposure. RESULTS: Prenatal exposure to various highly-correlated, traffic-related air toxics during the second trimester increased GCT risk, particularly 1,3-butadiene (odds ratio [OR] = 1.51; 95% confidence interval [CI] = 1.01, 2.26) and meta/para-xylene (OR = 1.56; 95% CI = 1.10, 2.21). Analyses by subtype indicated elevated ORs for yolk sac tumors but not teratomas. CONCLUSION: Our estimated ORs are consistent with positive associations between some prenatal traffic-related air toxics and GCT risk, notably yolk sac tumors.
Authors: Zhi Chen; Leslie Robison; Roger Giller; Mark Krailo; Mary Davis; Stella Davies; Xiao-Ou Shu Journal: Int J Hyg Environ Health Date: 2005-09-19 Impact factor: 5.840
Authors: Daniel W Goldberg; John P Wilson; Craig A Knoblock; Beate Ritz; Myles G Cockburn Journal: Int J Health Geogr Date: 2008-11-26 Impact factor: 3.918
Authors: Clinton Hall; Johnni Hansen; Ondine S von Ehrenstein; Di He; Jørn Olsen; Beate Ritz; Julia E Heck Journal: Int Arch Occup Environ Health Date: 2020-02-05 Impact factor: 3.015
Authors: Clinton Hall; Johnni Hansen; Jørn Olsen; Di He; Ondine S von Ehrenstein; Beate Ritz; Julia E Heck Journal: Cancer Causes Control Date: 2021-04-28 Impact factor: 2.506